DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac13E and Gucy2e

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_570093.2	Gene:	Gucy2e / 113911	RGDID:	69322	Length:	1123	Species:	Rattus norvegicus

Alignment Length:	293	Identity:	78/293 - (26%)
Similarity:	134/293 - (45%)	Gaps:	54/293 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 NLVRMRGTFMKVGQNLLVRR--QLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPES 341
            :::||...:.:..:.|:..|  :||:|::..|:::..::||.||..|          ..|...|.
  Rat   832 SMLRMLEKYSQSLEGLVQERTEELELERRKTERLLSQMLPPSVAHAL----------KMGTTVEP 886

  Fly   342 HYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSL 406
            .|                    .:.|:|.|:||||||.:|:.....::|..||||:..||.:...
  Rat   887 EY--------------------FDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDS 931

  Fly   407 SGCEKISTLGDCYYCVSGCPEPRAD-HAICCVEMGLGMIDAMRCFDAQRHE---GVKMRVGVHTG 467
            ....|:.|:||.|...||.|....: ||.....|.|.::.....| ..||.   .:::|.|:|:|
  Rat   932 HDVYKVETIGDAYMVASGLPRRNGNRHAAEIANMALEILSYAGNF-RMRHAPDVPIRVRAGLHSG 995

  Fly   468 TVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEG--------EE 524
            ..:.|:||....::.::.:.|:.|::|||:|.|.::|:|:.|...|   ..|:||        .|
  Rat   996 PCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSRNTVQAL---LSLDEGYKIDVRGQTE 1057

  Fly   525 VFG---HRTYFVVGRR---RDFTRTNSLSPSMP 551
            :.|   ..||::.|:.   |......|:.|..|
  Rat  1058 LKGKGLEETYWLTGKTGFCRSLPTPLSIQPGDP 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	60/219 (27%)
		Guanylate_cyc	361..535	CDD:278633	57/188 (30%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
Gucy2e	NP_570093.2	PBP1_sensory_GC_DEF-like	71..445	CDD:380594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..556
		PK_GC-2D	554..824	CDD:270945
		CYCc	861..1050	CDD:214485	62/222 (28%)
		Interaction with NCALD. /evidence=ECO:0000269\|PubMed:18178149	880..921		16/60 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810