Protein Alignment Ac13E and ADCY7

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_011521137.1
• Gene: ADCY7 / 113
• HGNCID: 238
• Length: 1086
• Species: Homo sapiens
• Alignment Length: 1563
• Identity: 365/1563 - (23%)
• Similarity: 557/1563 - (35%)
• Gaps: 563/1563 - (36%)

  Fly    75 DSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVV----DGGSEDFWRPISSSFSMLSL 135
            |...|.|:||      :..::...|..:||.:...|:..::    .|........:..:|.:|::
Human    17 DQDALYEKYQ------LTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAV 75

  Fly   136 -VTIMALCFTHWDLYREHRTVTSAVTALLLC-GASLAFLTYTGRAFSPLGHFAICLEIVLLIYTA 198
             ..:..|.:....|.|..|.:.....|.|:. |..|.|..:| :|..........|.||.::||.
Human    76 FAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWT-KAACAWEQVPFFLFIVFVVYTL 139

  Fly   199 LPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIM 263
            ||..: .||....:.|.|    ||:::                 .||.|.....||.|: .|:::
Human   140 LPFSM-RGAVAVGAVSTA----SHLLV-----------------LGSLMGGFTTPSVRV-GLQLL 181

  Fly   264 AHLSVHLVGVHVLIMNLVRMRGTFMK-----VGQNLL--------VRRQLEMEKQLKEKMIHSVM 315
            |:..:.|.|         .:.|.|.|     ..::|.        :||:|.:||:.:|.::.||:
Human   182 ANAVIFLCG---------NLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVL 237

  Fly   316 PPKVADML-------LNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFAD 373
            |..::..:       |.|.|    |...:|          .|:..||:...|    :|||||:||
Human   238 PAHISMGMKLAIIERLKEHG----DRRCMP----------DNNFHSLYVKRH----QNVSILYAD 284

  Fly   374 IVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVE 438
            |||||:::|..:.::||.:||:||.:||.:...:.|.:|..||||||||||.|.....||..||:
Human   285 IVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVK 349

  Fly   439 MGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQV 503
            |||.|..|::.........:.||||:|:|.||||::|.|:.::||||:||||||:||::|.|.:|
Human   350 MGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRV 414

  Fly   504 HISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGAS 568
            ||::.|...|..||.:|:|.           |::||
Human   415 HITEATLKHLDKAYEVEDGH-----------GQQRD----------------------------- 439

  Fly   569 LSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHP 633
                                                 |.|..:::
Human   440 -------------------------------------PYLKEMNI-------------------- 447

  Fly   634 AAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLP-PANPPAAETRSKIKLKVWKIPR 697
                         |..::|..:|        :|||.....|| |....|.:.|:.:::     .|
Human   448 -------------RTYLVIDPRS--------QQPPPPSQHLPRPKGDAALKMRASVRM-----TR 486

  Fly   698 FLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGY 762
            :|:         |.|.:....|                     ||..|:::..:..:.||
Human   487 YLE---------SWGAARPFAH---------------------LNHRESVSSGETHVPNG----- 516

  Fly   763 QQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDII 827
             :.|..|...||                           |:|:
Human   517 -RRPKSVPQRHR---------------------------RTPD---------------------- 531

  Fly   828 DVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRP 892
                     || :||.|||                         |..:...:....:|
Human   532 ---------RS-MSPKGRS-------------------------EDDSYDDEMLSAIE------- 554

  Fly   893 RASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSN 957
                             |.|||.|||..:......|.........|:..:.|...:|.|....|.
Human   555 -----------------GLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASL 602

  Fly   958 SRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMA 1022
            .....:...:..:.:||           :...|...:..|.||.|.|..........||..:
Human   603 IFVCILLVHVLLMPRTA-----------ALGVSFGLVACVLGLVLGLCFATKFSRCCPARGT--- 653

  Fly  1023 DPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAEN 1087
              |....:::..|..|:|...|..........::..||..|.:      .|....::.....|.:
Human   654 --LCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQV------PELPVGNETGLLAASS 710

  Fly  1088 ETEGPPTLATPRYNTYIDIFVGIAVYLC------ISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQ 1146
            :|.   .|..|           :..|.|      |:.|:||  :.::.|...|       .|...
Human   711 KTR---ALCEP-----------LPYYTCSCVLGFIACSVFL--RMSLEPKVVL-------LTVAL 752

  Fly  1147 VFALFLFTRQMCRRQS--GSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSW 1209
            |..|.||....|.:..  |..:.|..:...|||             |.|   ||:.:..:.::::
Human   753 VAYLVLFNLSPCWQWDCCGQGLGNLTKPNGTTS-------------GTP---SCSWKDLKTMTNF 801

  Fly  1210 YPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNC-WVRNVLAF 1273
            |               |::....||.|.:.              |.::|   :|:| |.
Human   802 Y---------------LVLFYITLLTLSRQ--------------IDYYC---RLDCLWK------ 828

  Fly  1274 LAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREF 1338
                                                 |.|:..|                  .||
Human   829 -------------------------------------KKFKKEH------------------EEF 838

  Fly  1339 EIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL----KNTAKYSENHHNIAIIF 1399
            |                     .|:|...:||.|::|.|||.|.    .|...|.:::..:.::|
Human   839 E---------------------TMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMF 882

  Fly  1400 ASIVNFNEMYDESYLG--GKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSH 1462
            ||:.:|...|.|..:.  |.|.||:|||:|.||||||.:|:|..||||||||||:|||:||..:.
Human   883 ASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVAS 947

  Fly  1463 RGTGDE------HIHTLMEFSIAMQEVVDAFNKDLLEFNLI-LRIGMNIGDVTAGVIGTSKLYYD 1520
            .....|      ||..::|||||:...:|..|:.  .||.. ||:|:|.|.|.|||||..|..||
Human   948 GHENQELERQHAHIGVMVEFSIALMSKLDGINRH--SFNSFRLRVGINHGPVIAGVIGARKPQYD 1010

  Fly  1521 IWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNR----------YEFEPRGSVYVKGKDHMEVFL 1575
            |||:.|||||||:|||...:|||.   |||....          |..|.||.:.||||..:..:.
Human  1011 IWGNTVNVASRMESTGELGKIQVS---LPFQVTEETCTILQGLGYSCECRGLINVKGKGELRTYF 1072

  Fly  1576 YTT 1578
            ..|
Human  1073 VCT 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	90/222 (41%)
		PHA03307	836..>1015	CDD:223039	30/178 (17%)
		Guanylate_cyc	1388..1575	CDD:425528	91/205 (44%)
ADCY7	XP_011521137.1	AcyC	47..432	CDD:441717	135/435 (31%)
		Guanylate_cyc	270..453	CDD:425528	86/296 (29%)
		Adcy_cons_dom	485..593	CDD:461877	35/251 (14%)
		Guanylate_cyc	871..1073	CDD:425528	91/206 (44%)