DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and ADCY6

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001377760.1	Gene:	ADCY6 / 112	HGNCID:	237	Length:	1168	Species:	Homo sapiens

Alignment Length:	1589	Identity:	375/1589 - (23%)
Similarity:	559/1589 - (35%)	Gaps:	608/1589 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 PVAFERAAAKSW-------LDPKFDSPVLEEQYQASVFPHVRMRYRFTL---SYILLCSLMWCLY 112
            |.|..|:....|       ...:|.|..||..||         ||.|.:   |..||.:::..|.
Human   108 PDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQ---------RYFFQMNQSSLTLLMAVLVLLT 163

  Fly   113 FVVDGGSEDFWRPISSSFSMLS-----LVTIMALCFTHWDLYREHRT-----VTSAVTALLLCGA 167
            .|:........||..:..::|:     .|.:|.:|..|  .:|:...     |...:.|.:..|.
Human   164 AVLLAFHAAPARPQPAYVALLACAAALFVGLMVVCNRH--SFRQDSMWVVSYVVLGILAAVQVGG 226

  Fly   168 SLAFLTYTGRAFSPLGHFAICLEIVLLIYTALPMPL------WLGASTAISYSIAFEMVSHMVIG 226
            :||     ....||.......:..|.:.||.||:.:      .||.||.           |:::.
Human   227 ALA-----ADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTL-----------HLILA 275

  Fly   227 CSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVG 291
            ...       ..|.|.....:.||           ::..|..:::|:.......|..|..|.:..
Human   276 WQL-------NRGDAFLWKQLGAN-----------VLLFLCTNVIGICTHYPAEVSQRQAFQETR 322

  Fly   292 QNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKS-- 354
            ..:..|..|:.|.:.:|:::.||:|..|| |.:.|                        |:.:
Human   323 GYIQARLHLQHENRQQERLLLSVLPQHVA-MEMKE------------------------DINTKK 362

  Fly   355 ---LFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLG 416
               :|...::...:|||||||||.|||.::|..||::||..||:||.|||.|.:.:.|.:|..||
Human   363 EDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILG 427

  Fly   417 DCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKF 481
            ||||||||.||.|||||.||||||:.||:|:..........|.||||:|:|.|.||::|.|:.:|
Human   428 DCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQF 492

  Fly   482 DVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSL 546
            |||||||:|||.||:.|:..::||::.|..:|...|.:|.|..          |.|..:.:...:
Human   493 DVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRG----------GERNAYLKEQHI 547

  Fly   547 SPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSL 611
                      .:.|:.||     ||......|:...:                    .|.|..|:
Human   548 ----------ETFLILGA-----SQKRKEEKAMLAKL--------------------QRTRANSM 577

  Fly   612 SMKM------RKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVS 670
            ...|      |..|:::|....|.:      ||..            ::|...|:.|:
Human   578 EGLMPRWVPDRAFSRTKDSKAFRQM------GIDD------------SSKDNRGTQDA------- 617

  Fly   671 PPLLPPANPP---------AAETRSKIKLKVWKIPRFLKRF--EDLTNRSSCGGSSSAGHLDKER 724
                  .||.         |.:.||..:|:...:.|||..|  |||..:.|
Human   618 ------LNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYS-------------- 662

  Fly   725 EREREKEKEELHQHNQLNPE-------ETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPA 782
                          .:::|.       ..|.|          |....:.:|: ..|.|..|.|
Human   663 --------------RKVDPRFGAYVACALLVF----------CFICFIQLLI-FPHSTLMLGI-- 700

  Fly   783 ARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSG 847
                  :|:....|..:||            .|:  .||
Human   701 ------YASIFLLLLITVL------------ICA--VYS-------------------------- 719

  Fly   848 SYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPS 912

Human   720 ----------------------------------------------------------------- 719

  Fly   913 STSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQ 977
                 |          |.:||....|.|                   ||.::.:.::   ||:..
Human   720 -----C----------GSLFPKALQRLS-------------------RSIVRSRAHS---TAVGI 747

  Fly   978 HRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQM-----ADPLAACLQQLRKQSD 1037
            ..|...|||:.:::......     |:.          :|:::|     ||..|..||||.....
Human   748 FSVLLVFTSAIANMFTCNHT-----PIR----------SCAARMLNLTPADITACHLQQLNYSLG 797

  Fly  1038 LQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGP-PTLATPRYN 1101
            |....|                                              ||. ||.:.|.|
Human   798 LDAPLC----------------------------------------------EGTMPTCSFPEY- 815

  Fly  1102 TYIDIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNV 1166
                 |:|..:...::.|:||    .:|...:|          ..:|.|.|
Human   816 -----FIGNMLLSLLASSVFL----HISSIGKL----------AMIFVLGL-------------- 847

  Fly  1167 SNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANF 1231
                                                           |.|.:|:..|...|..|:
Human   848 -----------------------------------------------IYLVLLLLGPPATIFDNY 865

  Fly  1232 -LLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRS 1295
             |||.                   ||                        |:|       |.|.:
Human   866 DLLLG-------------------VH------------------------GLA-------SSNET 880

  Fly  1296 DQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLN-REFEIGYRLTFYGNAVANQDKVRV 1359
            ....|..|:..: .:|:....       :||:..|..:|: ::.|...||.|.....|..:|..:
Human   881 FDGLDCPAAGRV-ALKYMTPV-------ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEM 937

  Fly  1360 QNMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAIIFASIVNFNEMYDESYLG--GK 1417
            :.::.....|||||:||.||.|.     :|...|.::...:|::||||.||:|.|.|....  |.
Human   938 EELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGV 1002

  Fly  1418 EFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPS-HRGTGDEHIHTLMEFSIAMQ 1481
            |.||:|||:|.||||::|...||.:|||||||||:||||||:.| :...|..||..|.::::.:.
Human  1003 ECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLM 1067

  Fly  1482 EVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKD 1546
            |.:...|:.... |..::||:|:|.|.|||||..|..|||||:.|||:|||||||:|:||||..|
Human  1068 EQMKHINEHSFN-NFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTD 1131

  Fly  1547 CLPFLTNR-YEFEPRGSVYVKGKDHMEVF 1574
            ....|..: |:.|.||.|.||||..|..:
Human  1132 LYQVLAAKGYQLECRGVVKVKGKGEMTTY 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	94/220 (43%)
		Guanylate_cyc	361..535	CDD:278633	86/173 (50%)
		CYCc	1362..1556	CDD:214485	93/202 (46%)
		Guanylate_cyc	1388..1575	CDD:278633	92/191 (48%)
ADCY6	NP_001377760.1	AC_N	<16..368	CDD:318454	64/329 (19%)
		Guanylate_cyc	370..554	CDD:306677	89/203 (44%)
		DUF1053	582..668	CDD:399378	23/144 (16%)
		Guanylate_cyc	970..1164	CDD:306677	92/192 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810