Protein Alignment Ac13E and ADCY5

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Alignment Length: 1591
• Identity: 373/1591 - (23%)
• Similarity: 570/1591 - (35%)
• Gaps: 587/1591 - (36%)

  Fly    51 SCCSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVV 115
            :||..:|.:         :...||.|..||..||         ||.|.|:...|..||
Human   207 ACCLALLQI---------FRSKKFPSDKLERLYQ---------RYFFRLNQSSLTMLM------- 246

  Fly   116 DGGSEDFWRPISSSFSMLSLVTIMALCF--THWDLYREHRTVTSAVTALL-----LCGASLAFLT 173
                           ::|.||.::.|.|  ....|...:..|.:|...::     ||..:.....
Human   247 ---------------AVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQD 296

  Fly   174 YTGRAFSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAF----------EMVSHMVIG-- 226
            :.|.|...|....:.:::|.|:   ||.|  ..||..|.:::.|          .|.:.::.|
Human   297 HMGLACYALIAVVLAVQVVGLL---LPQP--RSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVL 356

  Fly   227 CSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSV----HLVGVHVLIMNLVRMRGTF 287
            .||:|             ..:....:..::.|:.::::::.:    ::|||.......|..|..|
Human   357 LSALH-------------LAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAF 408

  Fly   288 MKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDV 352
            .:..:.:..|...:.|.|.:|:::.||:|..||                       |..:|..:.
Human   409 QETRECIQARLHSQRENQQQERLLLSVLPRHVA-----------------------MEMKADINA 450

  Fly   353 KS---LFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKIST 414
            |.   :|...::...:|||||||||.|||.::|..||::||..||:||.|||.|.:.:.|.:|..
Human   451 KQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKI 515

  Fly   415 LGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRV 479
            ||||||||||.||.|||||.||||||:.||:|:..........|.||||:|:|.|.||::|.|:.
Human   516 LGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW 580

  Fly   480 KFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTN 544
            :||||||||:|||.||:.||..::||::.|.::|...|.:|.|          ..|.|..:.:.:
Human   581 QFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPG----------CGGERNAYLKEH 635

  Fly   545 SLSPSMPANAT-----GSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSM 604
            |:...:....|     ..:::      |.:::..||                 |...||....:.
Human   636 SIETFLILRCTQKRKEEKAMI------AKMNRQRTN-----------------SIGHNPPHWGAE 677

  Fly   605 RPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPV 669
            ||....|......|...|             .|.       |.||            |.:.|
Human   678 RPFYNHLGGNQVSKEMKR-------------MGF-------EDPK------------DKNAQ--- 707

  Fly   670 SPPLLPPANPP---------AAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKERE 725
                 ..|||.         |.:.||..:|:...:.:||..|
Human   708 -----ESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTF----------------------- 744

  Fly   726 REREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCG--------YQQLPVLVESNHRTQTLDIPA 782
            ||.:.||:...|            :|::......|.        :.|:.:            :|.
Human   745 REPDLEKKYSKQ------------VDDRFGAYVACASLVFLFICFVQITI------------VPH 785

  Fly   783 ARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSG 847
            :..:|....|.:.|.:.|:                              ::|...|.:..|
Human   786 SIFMLSFYLTCSLLLTLVV------------------------------FVSVIYSCVKLF---- 816

  Fly   848 SYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPS 912
                                                                         |.|.
Human   817 -------------------------------------------------------------PSPL 820

  Fly   913 STSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQ 977
            .|                                .|||....|.||
Human   821 QT--------------------------------LSRKIVRSKMNS------------------- 834

  Fly   978 HRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIR 1042
             .:.|.||.:...::..                 :.|..|:|:   .|..||.|....|..|:..
Human   835 -TLVGVFTITLVFLAAF-----------------VNMFTCNSR---DLLGCLAQEHNISASQVNA 878

  Fly  1043 C-VRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGP--PTLATPRYNTYI 1104
            | |.::|.:            :||                  |.|....|.  |....|.|.||
Human   879 CHVAESAVN------------YSL------------------GDEQGFCGSPWPNCNFPEYFTY- 912

  Fly  1105 DIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNR 1169
                        ||.|                :|.:|...:|:
Human   913 ------------SVLL----------------SLLACSVFLQI---------------------- 927

  Fly  1170 FRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLLL 1234
                                       ||..::                            .|:|
Human   928 ---------------------------SCIGKL----------------------------VLML 937

  Fly  1235 DLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQ 1299
            .:|           ||:|.||.....|..:  ..::|....|:.|.....||..:..:.|  .::
Human   938 AIE-----------LIYVLIVEVPGVTLFD--NADLLVTANAIDFFNNGTSQWSLCENLR--HRR 987

  Fly  1300 DQEASNFIQEIKWFQDYH-----VEIYLDLLL-ILVLVWFLN-REFEIGYRLTFYGNAVANQDKV 1357
            .:..:.|...:|.....|     :::...::: :.||..:|: ::.|...||.|.....|.::|.
Human   988 MEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKE 1052

  Fly  1358 RVQNMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAIIFASIVNFNEMYDESYLG-- 1415
            .::.::.....|||||:||.||.|.     :|...|.::...:|::||||.||:|.|.|....
Human  1053 EMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNE 1117

  Fly  1416 GKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGL-DPSHRGTGDEHIHTLMEFSIA 1479
            |.|.||:|||:|.||||::|...||.:|||||||||:|||||| |.::...|..||..|.:|::.
Human  1118 GVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMK 1182

  Fly  1480 MQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVG 1544
            :.:.:...|:.... |..::||:|||.|.|||||..|..|||||:.|||||||||||:|:||||.
Human  1183 LMDQMKYINEHSFN-NFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVT 1246

  Fly  1545 KDCLPFL-TNRYEFEPRGSVYVKGKDHMEVF 1574
            .|....| .|.|:.|.||.|.||||..|..:
Human  1247 TDMYQVLAANTYQLECRGVVKVKGKGEMMTY 1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	96/218 (44%)
		PHA03307	836..>1015	CDD:223039	14/178 (8%)
		Guanylate_cyc	1388..1575	CDD:425528	95/191 (50%)
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	63/331 (19%)
		Guanylate_cyc	460..643	CDD:425528	90/192 (47%)
		Adcy_cons_dom	668..761	CDD:461877	29/167 (17%)
		Guanylate_cyc	1087..1281	CDD:425528	95/192 (49%)