Protein Alignment Ac13E and ADCY3

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_011530791.1
• Gene: ADCY3 / 109
• HGNCID: 234
• Length: 1186
• Species: Homo sapiens
• Alignment Length: 1654
• Identity: 378/1654 - (22%)
• Similarity: 580/1654 - (35%)
• Gaps: 643/1654 - (38%)

  Fly    47 GRRH--------SCCSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYIL 103
            ||.|        ||  :.|| .|.|..        |....||..|| :.|.  |.|:...|..::
Human    33 GRTHEISVRNSGSC--LCLP-RFMRLT--------FVPESLENLYQ-TYFK--RQRHETLLVLVV 83

  Fly   104 LCSLMWCLYFVVDGGSEDFWRPISSSFSMLSL----------VTIMALCFTHWDLYREHRTVTSA 158
            ..:|..| |.||      ....:.||..:.||          :.:..||        :...:...
Human    84 FAALFDC-YVVV------MCAVVFSSDKLASLAVAGIGLVLDIILFVLC--------KKGLLPDR 133

  Fly   159 VTALLLCGASLAFLTYTGRAFSPLG-HFAIC----------LEIVLLIYTALPMPLWLGASTAIS 212
            ||..:|  ..:.:|..|.:.||.|| :||..          :..|...:..||:.|    |..:.
Human   134 VTRRVL--PYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFFITLPLSL----SPIVI 192

  Fly   213 YSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLI 277
            .|:...:|..:|:|.:.                ..:...:.....|:..|:|::.::|..:.|.|
Human   193 ISVVSCVVHTLVLGVTV----------------AQQQQEELKGMQLLREILANVFLYLCAIAVGI 241

  Fly   278 MNLV----RMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLP 338
            |:..    :.|..|::..|:|.|:..||.:.|.:|.::.|::|..|||.:|.:
Human   242 MSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD------------ 294

  Fly   339 PESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDL 403
                 |:...|...:..|...:|:..||||||||||||||::||..:|::||::||:||.|||.|
Human   295 -----MKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKL 354

  Fly   404 CSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGT 468
            .:.....:|..|||||||:.|.|:.|.|||:|.:.|||.|::|:.....:...||.|||||||||
Human   355 AAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGT 419

  Fly   469 VLCGIVGTRRVKFDVWSNDVSLANKMESSGKP----------------------EQVHISQETSS 511
            ||.|::|.:|.::||||.||::|||||:.|.|                      |:|||||.|..
Human   420 VLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGGSKIEERLYSCVVAPTLRLRWERVHISQSTMD 484

  Fly   512 FLGDAYYLEEGE--------EVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGAS 568
            .|...:.:|.|:        |..|..||.::..:.:..:|.:      .|....|.|..||..:|
Human   485 CLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTAT------QNGLNGSALPNGAPASS 543

  Fly   569 LSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHP 633
            .|.|...:...:||       |...||.:.|                 :|.:.:|..     :.|
Human   544 KSSSPALIETKEPN-------GSAHSSGSTS-----------------EKPEEQDAQ-----LFP 579

  Fly   634 AAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRF 698
            ......|            .::.|||| .:|             ||.....|.:::|
Human   580 TTLSHLP------------HSRCLPGS-QAD-------------NPSFPNPRRRLRL-------- 610

  Fly   699 LKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEE------------------ 745
                :||.:|.          :|         ..|:.|:.|||..|.
Human   611 ----QDLADRV----------VD---------ASEDEHELNQLLNEALLERESAQVVKKRNTFLL 652

  Fly   746 TLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSG 810
            ::.|||.:|:.                                        ..||.:..::|.:.
Human   653 SMRFMDPEMET----------------------------------------RYSVEKEKQSGAAF 677

  Fly   811 GGGC----CSPGQYSMYDDIID---VRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAG 868
            ...|    |:    ::.:.:||   :.:|:
Human   678 SCSCVVLLCT----ALVEILIDPWLMTNYV----------------------------------- 703

  Fly   869 VGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFP 933
                                       |...|......|       :.|.|.|         |||
Human   704 ---------------------------TFMVGEILLLIL-------TICSLAA---------IFP 725

  Fly   934 PTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQ 998
            ....:                |..:..:.|.:..:|.|..|:
Human   726 RAFPK----------------KLVAFSTWIDRTRWARNTWAM----------------------- 751

  Fly   999 GLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKF 1063
             |.:.:.|.           :.:.|.| :|||
Human   752 -LAIFILVM-----------ANVVDML-SCLQ--------------------------------- 770

  Fly  1064 SLYFKSRQLERDFRSKAHRFGAENETEGPPT----LATPRYNTYIDIFVGIAVYLCISVS----- 1119
              |:.               |..|.|.|..|    |..|:|..|:.:...||..:.:.||
Human   771 --YYT---------------GPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKL 818

  Fly  1120 -LFLMTQNTVSP-SFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLER 1182
             |.|:....|:. :...|..:|..:.                       ..|||         |.
Human   819 TLMLLVAGAVATINLYAWRPVFDEYD-----------------------HKRFR---------EH 851

  Fly  1183 DERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYG 1247
            |                                      :|         ::.|||::.|.
Human   852 D--------------------------------------LP---------MVALEQMQGFN---- 865

  Fly  1248 FLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKW 1312
                                            .|:          |.:|.:.....|.:...:..
Human   866 --------------------------------PGL----------NGTDSRLPLVPSKYSMTVMV 888

  Fly  1313 FQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKH 1377
            |            |:::..::.:|..|...|..|......:..|.||..|:...:.|:.|::|:|
Human   889 F------------LMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEH 941

  Fly  1378 VAEHLKNTAK-----YSENHHNIAIIFASIVNFNEMYDESYL--GGKEFLRVLNELIGDFDELLS 1435
            ||.|...:.|     ||:.:..|.::|||:.||.:.|.|..:  ||.|.||.|||:|.|||.||.
Human   942 VARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLD 1006

  Fly  1436 RPEFRAVEKIKTIGSTFMAASGLDPSHRGTGD--------------EHIHTLMEFSIAMQEVVDA 1486
            .|:||.:.||||||||:|||||:.|.....|.              :|:..|.:|::||::.:..
Human  1007 NPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTN 1071

  Fly  1487 FNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFL 1551
            .|..... |.:||||||.|.|.|||||..|.:|||||:.|||||||:|||:...|||.::....|
Human  1072 INNQSFN-NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVIL 1135

  Fly  1552 TN-RYEFEPRGSVYVKGKDHMEVFLYTTR 1579
            .. .:.|..||.::||||..:..|....|
Human  1136 REYGFRFVRRGPIFVKGKGELLTFFLKGR 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	96/237 (41%)
		Guanylate_cyc	361..535	CDD:278633	91/203 (45%)
		CYCc	1362..1556	CDD:214485	91/215 (42%)
		Guanylate_cyc	1388..1575	CDD:278633	89/203 (44%)
ADCY3	XP_011530791.1	AC_N	<44..303	CDD:292831	70/326 (21%)
		CYCc	273..490	CDD:214485	96/233 (41%)
		Guanylate_cyc	310..516	CDD:278633	91/205 (44%)
		CYCc	925..1143	CDD:214485	91/218 (42%)
		Guanylate_cyc	956..1163	CDD:278633	90/207 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810