Protein Alignment Ac13E and ADCY2

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_065433.2
• Gene: ADCY2 / 108
• HGNCID: 233
• Length: 1091
• Species: Homo sapiens
• Alignment Length: 1606
• Identity: 354/1606 - (22%)
• Similarity: 571/1606 - (35%)
• Gaps: 637/1606 - (39%)

  Fly    66 AKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILL--CSLMWCLYFVVDGGSED---FWRP 125
            ::.||...:  ..:.:|:...||          |..|::  |..:..::|.:....||   |...
Human    29 SRDWLYESY--YCMSQQHPLIVF----------LLLIVMGSCLALLAVFFALGLEVEDHVAFLIT 81

  Fly   126 ISSSFSMLSLVTIMALCFTHWDLYREHRTVTSAVTALLLCGASLAFLTYTGRAFSPLGHFAICLE 190
            :.::.::...:.|: :|..  .::::...:.|.|..:.|......|:.: |...||....:..|.
Human    82 VPTALAIFFAIFIL-VCIE--SVFKKLLRLFSLVIWICLVAMGYLFMCF-GGTVSPWDQVSFFLF 142

  Fly   191 IVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVI--GC-SAIHGGPMHGGGGAAGGSGMEANGD 252
            |:.::||.||..:    ..||..|: ....||.::  .| ||..||..|
Human   143 IIFVVYTMLPFNM----RDAIIASV-LTSSSHTIVLSVCLSATPGGKEH---------------- 186

  Fly   253 PSNRILILRIMAHLSVHLVG-----VHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIH 312
                 |:.:|:|::.:.:.|     .|..:|.|. ::.|:......:..|.:||.||:.:|:::.
Human   187 -----LVWQILANVIIFICGNLAGAYHKHLMELA-LQQTYQDTCNCIKSRIKLEFEKRQQERLLL 245

  Fly   313 SVMPPKV-----ADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFA 372
            |::|..:     |:::....||.   ||.:         ..:|:..:|:...|    .|||||:|
Human   246 SLLPAHIAMEMKAEIIQRLQGPK---AGQM---------ENTNNFHNLYVKRH----TNVSILYA 294

  Fly   373 DIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCV 437
            |||||||::|..:..:||.:||:||.:||.:...:.|.:|..||||||||||.|....:||..||
Human   295 DIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCV 359

  Fly   438 EMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQ 502
            :|||.|.:|::.........:.||||||:|.||||::|.::.::||||:||:|||.||:.|.|.:
Human   360 KMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGR 424

  Fly   503 VHISQETSSFLGDAYYLEEGE------EVFGH--RTYFVV---GRRRDFTRTNSLSPSMPANATG 556
            ||||..|...|..||.:|||:      .:..|  :||||:   |.||
Human   425 VHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERR------------------ 471

  Fly   557 SSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQS 621
                                                      ||....|||.|....|||
Human   472 ------------------------------------------SPQHLFRPRHTLDGAKMR----- 489

  Fly   622 RDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRS 686
                                                                        |..|.
Human   490 ------------------------------------------------------------ASVRM 494

  Fly   687 KIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMD 751
            ...|:.|                  |.:....|               ||..:.:..|
Human   495 TRYLESW------------------GAAKPFAH---------------LHHRDSMTTE------- 519

  Fly   752 NQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCS 816
                                |.:..|.|:|.
Human   520 --------------------NGKISTTDVPM---------------------------------- 530

  Fly   817 PGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTA 881
             ||::.            |:|:
Human   531 -GQHNF------------QNRT------------------------------------------- 539

  Fly   882 PPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSA 946
                                                                             
Human   540 ----------------------------------------------------------------- 539

  Fly   947 TSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPP 1011
                   :::.|::...:::   ||:
Human   540 -------LRTKSQKKRFEEE---LNE--------------------------------------- 555

  Fly  1012 LLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDF 1076
                                       ::|:.: |...:|:.:|....:::.||.|.::.||:::
Human   556 ---------------------------RMIQAI-DGINAQKQWLKSEDIQRISLLFYNKVLEKEY 592

  Fly  1077 RSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNT--VSPSF-----RL 1134
            |:                .|.|.:..|:.  ....::.||.:...|:...|  :..||     .|
Human   593 RA----------------TALPAFKYYVT--CACLIFFCIFIVQILVLPKTSVLGISFGAAFLLL 639

  Fly  1135 WVTLFSCFTGIQVFALFLFTRQ-----MCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPH 1194
            ...||.||.|    .|...:::     |...:|...::||
Human   640 AFILFVCFAG----QLLQCSKKASPLLMWLLKSSGIIANR------------------------- 675

  Fly  1195 FESCADRIFEAISSWYPW-HICLAVLMAMPVLL--IIANFLLLDLEQ------------------ 1238
                            || .|.|.::....:|:  :...|.|.|.|:
Human   676 ----------------PWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNN 724

  Fly  1239 ----LEAFE-YHYGFLIFVCIVHF--CN-FTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRS 1295
                |.|.. :...:.|:.||:..  |: |.::|..::.::..:|   .:|.....|..::|...
Human   725 QVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVA---LVGYNTILLHTHAHVLG 786

  Fly  1296 DQQQDQ-EASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRV 1359
            |..|.. |.....:::|......:.|:...||:      |.|:.|...||.|.......:::..:
Human   787 DYSQVLFERPGIWKDLKTMGSVSLSIFFITLLV------LGRQNEYYCRLDFLWKNKFKKEREEI 845

  Fly  1360 QNMKNQADMLLHNIIPKHVAEH-----LKNTAKYSENHHNIAIIFASIVNFNEMYDESYLG--GK 1417
            :.|:|...:||.|::|.|||||     |||...|.:::..:.::||||.:|.|.|.||.:.  |.
Human   846 ETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGL 910

  Fly  1418 EFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLD--PSHRGTGDE-----HIHTLME 1475
            |.||:|||:|.|||:|||:|:|..||||||||||:|||:||.  ||...:.:.     ||.|::|
Human   911 ECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVE 975

  Fly  1476 FSIAMQEVVDAFNKDLLEFN-LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPN 1539
            |:.|:...:||.||.  .|| ..||:|:|.|.|.|||||..|..|||||:.|||||||||||:.:
Human   976 FAFALVGKLDAINKH--SFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLD 1038

  Fly  1540 RIQVGKD-CLPFLTNRYEFEPRGSVYVKGKDHMEVFLYTTRRDNPL 1584
            :|||.:: .|...|..|....||.:.||||..::.:...|.....|
Human  1039 KIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSL 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	89/220 (40%)
		PHA03307	836..>1015	CDD:223039	4/178 (2%)
		Guanylate_cyc	1388..1575	CDD:425528	95/197 (48%)
ADCY2	NP_065433.2	AcyC	59..470	CDD:441717	140/457 (31%)
		Guanylate_cyc	281..465	CDD:425528	87/187 (47%)
		Adcy_cons_dom	495..600	CDD:461877	30/412 (7%)
		Guanylate_cyc	878..1077	CDD:425528	95/200 (48%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	905..922		8/16 (50%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	990..993		0/4 (0%)