DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac13E and ADCY2

DIOPT Version :9

Sequence 1:NP_001259575.1 Gene:Ac13E / 32485 FlyBaseID:FBgn0022710 Length:1703 Species:Drosophila melanogaster
Sequence 2:NP_065433.2 Gene:ADCY2 / 108 HGNCID:233 Length:1091 Species:Homo sapiens


Alignment Length:1606 Identity:354/1606 - (22%)
Similarity:571/1606 - (35%) Gaps:637/1606 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 AKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILL--CSLMWCLYFVVDGGSED---FWRP 125
            ::.||...:  ..:.:|:...||          |..|::  |..:..::|.:....||   |...
Human    29 SRDWLYESY--YCMSQQHPLIVF----------LLLIVMGSCLALLAVFFALGLEVEDHVAFLIT 81

  Fly   126 ISSSFSMLSLVTIMALCFTHWDLYREHRTVTSAVTALLLCGASLAFLTYTGRAFSPLGHFAICLE 190
            :.::.::...:.|: :|..  .::::...:.|.|..:.|......|:.: |...||....:..|.
Human    82 VPTALAIFFAIFIL-VCIE--SVFKKLLRLFSLVIWICLVAMGYLFMCF-GGTVSPWDQVSFFLF 142

  Fly   191 IVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVI--GC-SAIHGGPMHGGGGAAGGSGMEANGD 252
            |:.::||.||..:    ..||..|: ....||.::  .| ||..||..|                
Human   143 IIFVVYTMLPFNM----RDAIIASV-LTSSSHTIVLSVCLSATPGGKEH---------------- 186

  Fly   253 PSNRILILRIMAHLSVHLVG-----VHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIH 312
                 |:.:|:|::.:.:.|     .|..:|.|. ::.|:......:..|.:||.||:.:|:::.
Human   187 -----LVWQILANVIIFICGNLAGAYHKHLMELA-LQQTYQDTCNCIKSRIKLEFEKRQQERLLL 245

  Fly   313 SVMPPKV-----ADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFA 372
            |::|..:     |:::....||.   ||.:         ..:|:..:|:...|    .|||||:|
Human   246 SLLPAHIAMEMKAEIIQRLQGPK---AGQM---------ENTNNFHNLYVKRH----TNVSILYA 294

  Fly   373 DIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCV 437
            |||||||::|..:..:||.:||:||.:||.:...:.|.:|..||||||||||.|....:||..||
Human   295 DIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCV 359

  Fly   438 EMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQ 502
            :|||.|.:|::.........:.||||||:|.||||::|.::.::||||:||:|||.||:.|.|.:
Human   360 KMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGR 424

  Fly   503 VHISQETSSFLGDAYYLEEGE------EVFGH--RTYFVV---GRRRDFTRTNSLSPSMPANATG 556
            ||||..|...|..||.:|||:      .:..|  :||||:   |.||                  
Human   425 VHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERR------------------ 471

  Fly   557 SSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQS 621
                                                      ||....|||.|....|||     
Human   472 ------------------------------------------SPQHLFRPRHTLDGAKMR----- 489

  Fly   622 RDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRS 686
                                                                        |..|.
Human   490 ------------------------------------------------------------ASVRM 494

  Fly   687 KIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMD 751
            ...|:.|                  |.:....|               ||..:.:..|       
Human   495 TRYLESW------------------GAAKPFAH---------------LHHRDSMTTE------- 519

  Fly   752 NQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCS 816
                                |.:..|.|:|.                                  
Human   520 --------------------NGKISTTDVPM---------------------------------- 530

  Fly   817 PGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTA 881
             ||::.            |:|:                                           
Human   531 -GQHNF------------QNRT------------------------------------------- 539

  Fly   882 PPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSA 946
                                                                             
Human   540 ----------------------------------------------------------------- 539

  Fly   947 TSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPP 1011
                   :::.|::...:::   ||:                                       
Human   540 -------LRTKSQKKRFEEE---LNE--------------------------------------- 555

  Fly  1012 LLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDF 1076
                                       ::|:.: |...:|:.:|....:::.||.|.::.||:::
Human   556 ---------------------------RMIQAI-DGINAQKQWLKSEDIQRISLLFYNKVLEKEY 592

  Fly  1077 RSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNT--VSPSF-----RL 1134
            |:                .|.|.:..|:.  ....::.||.:...|:...|  :..||     .|
Human   593 RA----------------TALPAFKYYVT--CACLIFFCIFIVQILVLPKTSVLGISFGAAFLLL 639

  Fly  1135 WVTLFSCFTGIQVFALFLFTRQ-----MCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPH 1194
            ...||.||.|    .|...:::     |...:|...::||                         
Human   640 AFILFVCFAG----QLLQCSKKASPLLMWLLKSSGIIANR------------------------- 675

  Fly  1195 FESCADRIFEAISSWYPW-HICLAVLMAMPVLL--IIANFLLLDLEQ------------------ 1238
                            || .|.|.::....:|:  :...|.|.|.|:                  
Human   676 ----------------PWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNN 724

  Fly  1239 ----LEAFE-YHYGFLIFVCIVHF--CN-FTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRS 1295
                |.|.. :...:.|:.||:..  |: |.::|..::.::..:|   .:|.....|..::|...
Human   725 QVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVA---LVGYNTILLHTHAHVLG 786

  Fly  1296 DQQQDQ-EASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRV 1359
            |..|.. |.....:::|......:.|:...||:      |.|:.|...||.|.......:::..:
Human   787 DYSQVLFERPGIWKDLKTMGSVSLSIFFITLLV------LGRQNEYYCRLDFLWKNKFKKEREEI 845

  Fly  1360 QNMKNQADMLLHNIIPKHVAEH-----LKNTAKYSENHHNIAIIFASIVNFNEMYDESYLG--GK 1417
            :.|:|...:||.|::|.|||||     |||...|.:::..:.::||||.:|.|.|.||.:.  |.
Human   846 ETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGL 910

  Fly  1418 EFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLD--PSHRGTGDE-----HIHTLME 1475
            |.||:|||:|.|||:|||:|:|..||||||||||:|||:||.  ||...:.:.     ||.|::|
Human   911 ECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVE 975

  Fly  1476 FSIAMQEVVDAFNKDLLEFN-LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPN 1539
            |:.|:...:||.||.  .|| ..||:|:|.|.|.|||||..|..|||||:.|||||||||||:.:
Human   976 FAFALVGKLDAINKH--SFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLD 1038

  Fly  1540 RIQVGKD-CLPFLTNRYEFEPRGSVYVKGKDHMEVFLYTTRRDNPL 1584
            :|||.:: .|...|..|....||.:.||||..::.:...|.....|
Human  1039 KIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSL 1084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac13ENP_001259575.1 CYCc 302..518 CDD:214485 89/220 (40%)
Guanylate_cyc 361..535 CDD:278633 85/184 (46%)
CYCc 1362..1556 CDD:214485 102/209 (49%)
Guanylate_cyc 1388..1575 CDD:278633 95/197 (48%)
ADCY2NP_065433.2 AC_N <33..260 CDD:292831 54/269 (20%)
CYCc 236..439 CDD:214485 88/218 (40%)
Guanylate_cyc 281..465 CDD:278633 87/187 (47%)
DUF1053 495..599 CDD:283888 29/411 (7%)
CYCc 848..1056 CDD:214485 102/209 (49%)
Guanylate_cyc 878..1077 CDD:278633 95/200 (48%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 905..922 8/16 (50%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 990..993 0/4 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.