DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and ADCY1

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_066939.1	Gene:	ADCY1 / 107	HGNCID:	232	Length:	1119	Species:	Homo sapiens

Alignment Length:	1565	Identity:	349/1565 - (22%)
Similarity:	530/1565 - (33%)	Gaps:	636/1565 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 FTHWDLYREHRTVTSAVTALLLCGASLAFLTYTGRAFSPLG-----HFAIC-LEIVLLIYT---A 198
            |..:.|..|......|:..|.|...:||.....|......|     |...| |.:.||:.|   :
Human    49 FRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRS 113

  Fly   199 LPMP-LWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANG----------- 251
            |.:| |......|:.:|:.|.::.     |....|||..|..|||||......|
Human   114 LQVPQLQQVGQLALLFSLTFALLC-----CPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVS 173

  Fly   252 -----------------------------DPSNRILILRIMA-----HLSVHLVGVHVLIMNLVR 282
                                         .|:.|..:.|.:.     .:.|::.||.|.|:....
Human   174 YALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERS 238

  Fly   283 MRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVA-----DMLLNEGGPSGLDAGGLPPESH 342
            .|..|::....:..|.:||.|.:.:|:::.|::|..||     |.|             .|||
Human   239 QRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFL-------------KPPE-- 288

  Fly   343 YMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLS 407
                       .:|...::...:|||||||||||||.::|..||::||::||:||.:||:|.:.:
Human   289 -----------RIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATEN 342

  Fly   408 GCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCG 472
            .|.:|..||||||||||..:|:.|||.|||||||.|||.:..........:.||||:|||.||||
Human   343 HCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCG 407

  Fly   473 IVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRR 537
            ::|.|:.::|||||||:|||.||::|.|.:|||::.|.:.|...|.:|.|   :||       .|
Human   408 VLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPG---YGH-------ER 462

  Fly   538 RDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVL 602
            ..|.:|:::....
Human   463 NSFLKTHNIETFF---------------------------------------------------- 475

  Fly   603 SMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQP 667
                                                   ||...|.||      .||.:.||
Human   476 ---------------------------------------IVPSHRRKI------FPGLILSD--- 492

  Fly   668 PVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEK 732
                  :.||.....:|...:.:::....:..|.....:|..:|.        |.::.|......
Human   493 ------IKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCE--------DDDKRRALRTAS 543

  Fly   733 EELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALA 797
            |:|...:        :|..|.:..
Human   544 EKLRNRS--------SFSTNVVYT----------------------------------------- 559

  Fly   798 SSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVN 862
                              :||        ..|..|||:.
Human   560 ------------------TPG--------TRVNRYISRL-------------------------- 572

  Fly   863 GAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVG 927
                    .|.|    ||  .:|.:.|
Human   573 --------LEAR----QT--ELEMADL-------------------------------------- 585

  Fly   928 GGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSIS 992
                             :..:.|...::...:...:|.:                ||||:.....
Human   586 -----------------NFFTLKYKHVEREQKYHQLQDE----------------YFTSAVVLTL 617

  Fly   993 NLGEVQGLGLPLAVQPPPP---LLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSY 1054
            .|..:.|| :.|.:.|...   ||:..|...    |.||:..|.    :..::|.
Human   618 ILAALFGL-VYLLIFPQSVVVLLLLVFCICF----LVACVLYLH----ITRVQCF---------- 663

  Fly  1055 LVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVYL----C 1115
                                                  |...|.:..|.:.||:.:.:|.    |
Human   664 --------------------------------------PGCLTIQIRTVLCIFIVVLIYSVAQGC 690

  Fly  1116 I------------SVSLFLMT---QNTVSPSFRLWVT---LFSCFTGIQVFALFLFTRQMCRRQS 1162
            :            :.||.:::   |.|..|:.....|   |..|..|....|:|
Human   691 VVGCLPWAWSSKPNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTLPLAIF----------- 744

  Fly  1163 GSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLI 1227
                   ||..|                                               :|.:::
Human   745 -------FRVSS-----------------------------------------------LPKMIL 755

  Fly  1228 IANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSH 1292
            ::...                ..::.::....:|:..                |.|||
Human   756 LSGLT----------------TSYILVLELSGYTRTG----------------GGAVS------- 781

  Fly  1293 NRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKV 1357
            .||                      .|..:.:||....:....|:.:|..||.:...|.|.:::.
Human   782 GRS----------------------YEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEERE 824

  Fly  1358 RVQNMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAIIFASIVNFNEMYDESYLGGK 1417
            .::.:|.....:|.|::|.|||:|.     :|...|.:::..:.::||||.|||:.|.|  |.|.
Human   825 DMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIE--LDGN 887

  Fly  1418 ----EFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTG-----DEHIHTL 1473
                |.||:|||:|.|||||:.:..::.:|||||||||:|||.||.|: .||.     ..|:.||
Human   888 NMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPT-SGTKAKKSISSHLSTL 951

  Fly  1474 MEFSIAMQEVVDAFNKDLLEFN-LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGL 1537
            .:|:|.|.:|:|..|..  .:| .:||:|:|:|.|.|||||..:..|||||:.|||||||||||:
Human   952 ADFAIEMFDVLDEINYQ--SYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGV 1014

  Fly  1538 PNRIQVGKDCLPFLTN-RYEFEPRGSVYVKGKDHMEVFLYTTRRDNPLDDDEADKVEQLG-TKKM 1600
            ..||||.::....|.. .|.|..||.|.||||..|..:....|.|.     ...::..|| .:||
Human  1015 QGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDG-----NGSQIRSLGLDRKM 1074

  Fly  1601 EHEGR 1605
            ...||
Human  1075 CPFGR 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	95/220 (43%)
		Guanylate_cyc	361..535	CDD:278633	88/173 (51%)
		CYCc	1362..1556	CDD:214485	92/209 (44%)
		Guanylate_cyc	1388..1575	CDD:278633	93/197 (47%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		AC_N	<161..292	CDD:292831	25/156 (16%)
		CYCc	258..453	CDD:214485	95/220 (43%)
		Guanylate_cyc	294..476	CDD:278633	91/282 (32%)
		Interaction with calmodulin. /evidence=ECO:0000250	493..520		3/26 (12%)
		CYCc	826..1037	CDD:214485	94/215 (44%)
		Guanylate_cyc	859..1056	CDD:278633	93/201 (46%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810