DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and Adcy3

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_612178.2	Gene:	Adcy3 / 104111	MGIID:	99675	Length:	1145	Species:	Mus musculus

Alignment Length:	1618	Identity:	376/1618 - (23%)
Similarity:	577/1618 - (35%)	Gaps:	605/1618 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GRRH--------SCCSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYIL 103
            ||.|        ||  :.|| .|.|..        |....||..|| :.|.  |.|:...|..::
Mouse    33 GRTHEISVRNSGSC--LCLP-RFMRLT--------FVPESLENLYQ-TYFK--RQRHETLLVLVV 83

  Fly   104 LCSLMWCLYFVVDGG---SEDFWRPIS-SSFSMLSLVTIMALCFTHWDLYREHRTVTSAVTALLL 164
            ..:|..| |.||...   |.|...|:. :.|.::..:.:..||.......|..|.|...:..||:
Mouse    84 FAALFDC-YVVVMCAVVFSSDKLAPLMVAGFGLVLDIILFVLCKKGLLPDRVSRKVVPYLLWLLI 147

  Fly   165 CGASLAFLTYTGRAFS-------PLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSH 222
               |....:|.|..||       .:|..|.   .|...:..||:.|    |..:..|:...:|..
Mouse   148 ---SAQIFSYLGLNFSRAHAASDTVGWQAF---FVFSFFITLPLSL----SPIVIISVVSCVVHT 202

  Fly   223 MVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTF 287
            :|:|.:            .|.....|..|....|.::..:..:|...:||:....|...:.|..|
Mouse   203 LVLGVT------------VAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAF 255

  Fly   288 MKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDV 352
            ::..|:|.|:..||.:.|.:|.::.|::|..|||.:|.:                 |:...|...
Mouse   256 LEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD-----------------MKKDESQKD 303

  Fly   353 KSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGD 417
            :..|...:|:..||||||||||||||::||..:|::||::||:||.|||.|.:.....:|..|||
Mouse   304 QQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGD 368

  Fly   418 CYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFD 482
            ||||:.|.|:.|.|||:|.:.|||.|::|:.....:...||.|||||||||||.|::|.:|.::|
Mouse   369 CYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYD 433

  Fly   483 VWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGE--------EVFGHRTYFVVGRRRD 539
            |||.||::|||||:.|.|.:|||||.|...|...:.:|.|:        :..|..||.::..:.:
Mouse   434 VWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIASKPE 498

  Fly   540 FTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSM 604
            ..:|                          :|:..|.||| ||..|||     |...:|:.:.:.
Mouse   499 VKKT--------------------------AQNGLNGSAV-PNGAPAS-----SKPSSPALIETK 531

  Fly   605 RPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPV 669
            .|                     .|..|.:.:                      .|.:::||...
Mouse   532 EP---------------------NGSAHASGS----------------------TSEEAEEQEAQ 553

  Fly   670 SPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEE 734
            :.      ||.....|.:::|            :||.:|.          :|         ..|:
Mouse   554 AD------NPSFPNPRRRLRL------------QDLADRV----------VD---------ASED 581

  Fly   735 LHQHNQLNPEE------------------TLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIP 781
            .|:.|||..|.                  |:.|||.:|:.
Mouse   582 EHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMET------------------------- 621

  Fly   782 AARPVLHHAATSTALASSVLRSPEAGVSGGGGC----CSPGQYSMYDDIID---VRSYISQSRSD 839
                           ..||.:..::|.:....|    |:    :|.:.:||   :.:|:
Mouse   622 ---------------RYSVEKEKQSGAAFSCSCVVLFCT----AMVEILIDPWLMTNYV------ 661

  Fly   840 ISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTP 904
                                                                    |...|....
Mouse   662 --------------------------------------------------------TFVVGEVLL 670

  Fly   905 NSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYA 969
            ..|       :.|.:.|         |||.:..:                |..:..|.|.:..:|
Mouse   671 LIL-------TICSMAA---------IFPRSFPK----------------KLVAFSSWIDRTRWA 703

  Fly   970 LNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRK 1034
            .|..|:                        |.:.:.|.           :.:.|.| :|||
Mouse   704 RNTWAM------------------------LAIFILVM-----------ANVVDML-SCLQ---- 728

  Fly  1035 QSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPR 1099
                               |.:.|                      :...|..|.:| ..:..|:
Mouse   729 -------------------YYMGP----------------------YNMTAGMELDG-GCMENPK 751

  Fly  1100 YNTYIDIFVGIAVYLCISVS-------LFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQM 1157
            |..|:.:...||..:.:.||       :.|:|....:.:...|..:|..:.
Mouse   752 YYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTALNLYAWCPVFDEYD-------------- 802

  Fly  1158 CRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAM 1222
                     ..||:.|.:....||:.:..|.||            .....|..|
Mouse   803 ---------HKRFQEKDSPMVALEKMQVLATPG------------LNGTDSRLP----------- 835

  Fly  1223 PVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQL 1287
                            |...:|....::||.::.|..|::
Mouse   836 ----------------LVPSKYSMTVMMFVMMLSFYYFSR------------------------- 859

  Fly  1288 MVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVA 1352
                                         |||    .|...:.:|    :.|:
Mouse   860 -----------------------------HVE----KLARTLFLW----KIEV------------ 875

  Fly  1353 NQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAK-----YSENHHNIAIIFASIVNFNEMYDES 1412
            :..|.||..|:...:.|:.|::|:|||.|...:.|     ||:::..|.::|||:.||.:.|.|.
Mouse   876 HDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEE 940

  Fly  1413 YL--GGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGD-------- 1467
            .:  ||.|.||.|||:|.|||.||..|:||.:.||||||||:|||||:.|.....|.
Mouse   941 SINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSSKEEK 1005

  Fly  1468 ------EHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAV 1526
                  :|:..|.:|::||::.:...|..... |.:||||||.|.|.|||||..|.:|||||:.|
Mouse  1006 SDKERWQHLADLADFALAMKDTLTNINNQSFN-NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTV 1069

  Fly  1527 NVASRMDSTGLPNRIQVGKDCLPFLTN-RYEFEPRGSVYVKGKDHMEVFLYTTRRDNP 1583
            ||||||:|||:...|||.::....|.. .:.|..||.::||||..:..| :...||.|
Mouse  1070 NVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTF-FLKGRDRP 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	95/215 (44%)
		Guanylate_cyc	361..535	CDD:278633	89/181 (49%)
		CYCc	1362..1556	CDD:214485	91/215 (42%)
		Guanylate_cyc	1388..1575	CDD:278633	89/203 (44%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454	72/312 (23%)
		Guanylate_cyc	310..494	CDD:306677	89/183 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..564		20/114 (18%)
		Guanylate_cyc	915..1122	CDD:306677	90/208 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810