DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac13E and Adcy4

DIOPT Version :9

Sequence 1:NP_001259575.1 Gene:Ac13E / 32485 FlyBaseID:FBgn0022710 Length:1703 Species:Drosophila melanogaster
Sequence 2:NP_001348533.1 Gene:Adcy4 / 104110 MGIID:99674 Length:1077 Species:Mus musculus


Alignment Length:1585 Identity:369/1585 - (23%)
Similarity:553/1585 - (34%) Gaps:613/1585 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 LEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVVDGGSEDFW---RPISSSFSMLSLV---- 136
            |.:||...:.          |..|:||:|: .|..|.       |   |.::|..|.|:.|    
Mouse    23 LSQQYPLLIL----------LLVIVLCALV-ALPAVA-------WASGRELTSDPSFLTTVLCAL 69

  Fly   137 ----TIMALCFTHWDLYREHRTVTSAV-TALLLCGASLAFLTYTGRAFSPLGHFAICLEIVLLIY 196
                .::.|......|.|..|.::..: .|||..|....|   ||...|.....:..|.|:..:|
Mouse    70 GGFSLLLGLASREQQLQRWTRPLSGLIWVALLALGYGFLF---TGGVVSAWDQVSFFLFIIFTVY 131

  Fly   197 TALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDP-SNRILIL 260
            ..||:.:...|:..:..|:     ||:::                   .|:.....| |.|.|:.
Mouse   132 AMLPLGMRDAAAAGVISSL-----SHLLV-------------------LGLYLGWQPESQRALLP 172

  Fly   261 RIMAHLSVHLVG-----VHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVA 320
            ::.|:..:.|.|     .|..:|... :|.||.:...:|..||:|:.||:.:|.::.|::|..:|
Mouse   173 QLAANAVLFLCGNVVGAYHKALMERA-LRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLA 236

  Fly   321 DMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKT 385
            ..:..| ..:.|.||      ...||..:|:..||:...|    :.||:|:||||||||::|..:
Mouse   237 REMKAE-IMARLQAG------QRSRPENTNNFHSLYVKRH----QGVSVLYADIVGFTRLASECS 290

  Fly   386 AEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCF 450
            .::||.:||:||.:||.:.....|.:|..||||||||||.|....||||.||.|||.|..|:|..
Mouse   291 PKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKL 355

  Fly   451 DAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGD 515
            .......:.||||||:|:||||::|.::.::||||:||:|||.||:.|.|.:|||:..|.:.|..
Mouse   356 RVATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG 420

  Fly   516 AYYLEEGE--------EVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQS 572
            ||.:|..:        ...|..||.|:..|                                   
Mouse   421 AYAVERADTEHRDPYLRELGEPTYLVIDPR----------------------------------- 450

  Fly   573 ATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAG 637
                                                             .:.:.|:|        
Mouse   451 -------------------------------------------------AEEEDEKG-------- 458

  Fly   638 IPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRF 702
                           |.|.|..||   |...:.|.||                    :.|:|:  
Mouse   459 ---------------TAKGLLSSL---EGHTMRPSLL--------------------MTRYLE-- 483

  Fly   703 EDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPV 767
                   |.|.:....||                                               
Mouse   484 -------SWGAAKPFAHL----------------------------------------------- 494

  Fly   768 LVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSY 832
                :|    ||.|        .:|||.|       ||...|        .|:|           
Mouse   495 ----SH----LDSP--------VSTSTPL-------PEKAFS--------PQWS----------- 517

  Fly   833 ISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTL 897
            :.:||:                           |.|:..|...|.::....:||           
Mouse   518 LDRSRT---------------------------PRGLDDELDTGDAKFFQVIEQ----------- 544

  Fly   898 ATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSS 962
                                                                      .||::  
Mouse   545 ----------------------------------------------------------LNSQK-- 549

  Fly   963 IQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAA 1027
                                                                             
Mouse   550 ----------------------------------------------------------------- 549

  Fly  1028 CLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKA------------ 1080
               |.::..|..|:                      :|||:.:::|:.:|..|            
Mouse   550 ---QWKQSKDFNLL----------------------TLYFREKEMEKQYRLSALPAFKYYAACTF 589

  Fly  1081 ----HRFGAEN-ETEGPPTLATPRYNTYIDIFVGIAVYLCISVSLFLMTQN-------------- 1126
                ..|..:. .|..||.|......|::..|  :.:::|.|..|....|.              
Mouse   590 LVFLSNFTIQMLVTTRPPALIITYSITFLLFF--LLLFVCFSEHLTKCVQKGPKMLHWLPALSVL 652

  Fly  1127 -TVSPSFRL---WVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGA 1187
             ...|.||:   ..|:...||......|||.....|...: ||||:     .|.:...|      
Mouse   653 VATRPGFRVALGTATILLVFTMAIASLLFLPVSSDCLFLA-SNVSS-----VTFNASWE------ 705

  Fly  1188 APGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFV 1252
            .||..|...      ...||..|..|.|            :..||...|....:||... .|:.:
Mouse   706 MPGSLPLIS------IPLISIPYSMHCC------------VLGFLSCSLFLHMSFELKL-LLLLL 751

  Fly  1253 CIVHFCN-FTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDY 1316
            .:|..|: |...:.|:.:        |.|.            |..|.........::|.|.....
Mouse   752 WLVASCSLFLHSHAWLSD--------CLIA------------RLYQSPSDSRPGVLKEPKLMGAI 796

  Fly  1317 HVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVA-- 1379
            :..|:...||:|.      |:.|...||.|.......|::...:.|:|...:||.|::|.|||  
Mouse   797 YFFIFFFTLLVLA------RQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQ 855

  Fly  1380 ---EHLKNTAKYSENHHNIAIIFASIVNFNEMYDESYLG--GKEFLRVLNELIGDFDELLSRPEF 1439
               ::.:|...|.:::..:.::|||:.:|.|.|.||.:.  |.|.||:|||:|.|||||||:|:|
Mouse   856 FIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKF 920

  Fly  1440 RAVEKIKTIGSTFMAASGLD-PSHRGTGDE------HIHTLMEFSIAMQEVVDAFNKDLLEFNLI 1497
            ..||||||||||:|||:||: .|.:.|..:      |:.|::||::|:...:...||.... |..
Mouse   921 SGVEKIKTIGSTYMAATGLNATSGQDTQQDSERSCSHLGTMVEFAVALGSKLGVINKHSFN-NFR 984

  Fly  1498 LRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTN-RYEFEPRG 1561
            ||:|:|.|.|.|||||..|..|||||:.|||||||:|||:..:|||.::....|.: .|....||
Mouse   985 LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETARALQSLGYTCYSRG 1049

  Fly  1562 SVYVKGKDHM-EVFLYT--TRRDNP 1583
            |:.||||..: ..||.|  ||..:|
Mouse  1050 SIKVKGKGELCTYFLNTDLTRTGSP 1074

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac13ENP_001259575.1 CYCc 302..518 CDD:214485 92/215 (43%)
Guanylate_cyc 361..535 CDD:278633 82/181 (45%)
CYCc 1362..1556 CDD:214485 92/208 (44%)
Guanylate_cyc 1388..1575 CDD:278633 90/197 (46%)
Adcy4NP_001348533.1 AC_N <115..246 CDD:318454 34/156 (22%)
Guanylate_cyc 264..418 CDD:306677 76/157 (48%)
DUF1053 479..580 CDD:368844 38/386 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..524 11/74 (15%)
Guanylate_cyc 866..1065 CDD:306677 91/199 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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