Protein Alignment Ac13E and adcy4

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_002934331.3
• Gene: adcy4 / 100497212
• XenbaseID: XB-GENE-984909
• Length: 1072
• Species: Xenopus tropicalis
• Alignment Length: 1572
• Identity: 337/1572 - (21%)
• Similarity: 534/1572 - (33%)
• Gaps: 663/1572 - (42%)

  Fly   142 CFTHWDLYREHRTVTSAVTALLL--------CGASLAFLTYTGRAFS-----------PLGHFAI 187
            |.....||..:..:|.....:||        |.|.:.....|||.||           .||.|:|
 Frog    16 CEKEGPLYETYYRLTQQYPVILLLLLIVLAVCCALIIITFATGRTFSDNVGFLVTLFCALGVFSI 80

  Fly   188 -------------CLEI-----------------------------------VLLIYTALPM--- 201
                         |::|                                   ::.:||.||:
 Frog    81 LFIPVCIKKVVQKCMQIIGVVILGCLVTLGYVFIFTSGLVSAWDQIYWTLFVIISLYTMLPLGMK 145

  Fly   202 -PLWLGASTAISY-----------------SIAFEMVSHMVI-GCSAIHGGPMHGGGGAAGGSGM 247
             .::.|.|..:::                 .:|.:|::..|| .|..:.|
 Frog   146 WAIFAGLSCFVAHIIVLSVYVSTVRLLPRDDVALQMIADAVILLCGNVIG--------------- 195

  Fly   248 EANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIH 312
                                    |.|..:.... ::.|:.:....:..|.:|..:::.:|:::.
 Frog   196 ------------------------GYHKCVTESA-LKDTYHEAINFIHSRLKLVSQERQQERLLL 235

  Fly   313 SVMPPKVADML-------LNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSIL 370
            |::|..:|..:       |.|..|               :|..:|:..:|:...|    ::||||
 Frog   236 SILPAYIATEMKAEIIERLKEKRP---------------QPENTNNFHNLYIKRH----KDVSIL 281

  Fly   371 FADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAIC 435
            :|||||||.:||..:.::||.:||:||.:||.:...:.|.:|..||||||||||.||...:||..
 Frog   282 YADIVGFTLLSSECSPKELVLMLNELFGKFDQIAKDNECMRIKILGDCYYCVSGLPEFLPNHAKN 346

  Fly   436 CVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKP 500
            ||.|||.|..|:|.........:.||||||:|.||||::|.::.::||||:||:|||.||:.|.|
 Frog   347 CVLMGLDMCQAIRKLRKATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVP 411

  Fly   501 EQVHISQETSSFLGDAY------------YLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPAN 553
            .:|||::.|.|.|.:.|            ||:|.    ..:||.|:..|.:......:.||..|.
 Frog   412 GRVHITEATLSHLENEYEVEDATLAQRDLYLKEN----NIKTYLVIDPRANDGEAEDILPSKSAE 472

  Fly   554 ATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKK 618
            .                                                   |::.: |::|.:.
 Frog   473 V---------------------------------------------------PKMRA-SVRMTRY 485

  Fly   619 SQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAE 683
            .:|  ...|:...|           :..|..::....|:..|:|           ||.:  |.::
 Frog   486 LES--WGAEKPFAH-----------LSHRDSLVPEPHSISHSMD-----------LPMS--PLSQ 524

  Fly   684 TRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLA 748
            |        |                           .:|:.|...:..|.|:.:|
 Frog   525 T--------W---------------------------SQEKSRSTRETNESLNDNN--------- 545

  Fly   749 FMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGG 813
                         :..:.||
 Frog   546 -------------FHIMEVL--------------------------------------------- 552

  Fly   814 CCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTS 878
             .|..|:....|...:..|.:...::       ..||
 Frog   553 -ASQRQWKRSKDFNRITLYFNDKAAE-------KEYR---------------------------- 581

  Fly   879 QTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSIC 943
                   .|.||..:..|                   .||.
 Frog   582 -------LSDLPSFKYYT-------------------ACCF------------------------ 596

  Fly   944 PSATSRKDSGIKSNSRRSSIQQQIYALN---QTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLA 1005
                                  .|:|.|   |..:| |:.:.:           |...|:.....
 Frog   597 ----------------------FIFACNFIVQILVS-HKNAAF-----------GISYGISFFFF 627

  Fly  1006 VQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPP-----LRKFSL 1065
            :     ||:..|   .|..||.|                          ::|.|     |...|:
 Frog   628 L-----LLLFTC---FAGHLARC--------------------------ILKGPQLLHWLPSLSI 658

  Fly  1066 YFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSP 1130
            ...||                      |.|..|         :|:...|.:.|
 Frog   659 ALSSR----------------------PWLRVP---------LGVFTILTVLV------------ 680

  Fly  1131 SFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHF 1195
                          :.||.||......|.:||.:         |:.|.|.|.....:.|
 Frog   681 --------------MAVFNLFFLPDNNCPQQSWN---------SSLSPDPEPQMLYSLP------ 716

  Fly  1196 ESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNF 1260
                          |..:.|:..|:|      .:.|||::      ||.....|....:::...|
 Frog   717 --------------YYMYCCILGLLA------CSAFLLMN------FEAKLILLSIALVIYNVIF 755

  Fly  1261 TQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLL 1325
            .:.:.|:.:        |::     ..:..:|:|         ...::|.|......:.|:...|
 Frog   756 LETHSWLSD--------CYV-----NWLYMNHSR---------PGILKEPKVMGSISLFIFFFTL 798

  Fly  1326 LILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL-----KNT 1385
            |.      |:|:.|...||.|........::.|::.|:|...:||.|::|..||:..     :|.
 Frog   799 LA------LSRQNEYYCRLDFLWKRKFKMERERIETMENLNRVLLENVLPADVAQQFIGQNRRNE 857

  Fly  1386 AKYSENHHNIAIIFASIVNFNEMY---DESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKT 1447
            ..|.:::..:.::||||.:|.|.|   ||:: .|.|.||:|||:|.|||||||:|:|.:||||||
 Frog   858 DLYYQSYDCVCVLFASIPDFKEFYTECDENH-EGLECLRLLNEIIADFDELLSKPKFSSVEKIKT 921

  Fly  1448 IGSTFMAASGLDPSHRGTGDE----------HIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGM 1502
            |||.:|||:||:.:   :|.|          ||..::||:||:...:|..||.... |..||:|:
 Frog   922 IGSAYMAATGLNAT---SGQENPQDGDRNYNHIGIMVEFAIALIGKLDLINKHSFN-NFKLRVGI 982

  Fly  1503 NIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTN-RYEFEPRGSVYVK 1566
            |.|.|.|||||..|..|||||:.|||||||||||:..:|||.::....|.. .|:.|.||.:.||
 Frog   983 NHGPVVAGVIGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEETTKVLEKLGYKCERRGVIKVK 1047

  Fly  1567 GKDHMEVFLYTT 1578
            ||..:..:..:|
 Frog  1048 GKGQLCTYFVST 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	88/234 (38%)
		Guanylate_cyc	361..535	CDD:278633	83/185 (45%)
		CYCc	1362..1556	CDD:214485	94/212 (44%)
		Guanylate_cyc	1388..1575	CDD:278633	93/200 (47%)
adcy4	XP_002934331.3	AC_N	<17..250	CDD:318454	39/272 (14%)
		Guanylate_cyc	270..427	CDD:306677	78/160 (49%)
		DUF1053	483..586	CDD:399378	26/273 (10%)
		Guanylate_cyc	859..1057	CDD:306677	93/202 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910