Protein Alignment Ac13E and adcy9

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_003201145.2
• Gene: adcy9 / 100333702
• ZFINID: ZDB-GENE-050208-455
• Length: 1392
• Species: Danio rerio
• Alignment Length: 1773
• Identity: 513/1773 - (28%)
• Similarity: 740/1773 - (41%)
• Gaps: 591/1773 - (33%)

  Fly     7 QSVSSRAMPPGVLVNDSRANSTDDIQIALAPHIQTYLSQTGRRHSCCSVMLPVAFERAAAKSWLD 71
            |||....|........|.::|....::.:...:.|:||...|        :|..|||:||:.| |
Zfish    40 QSVDHPDMSSSKPCKYSISSSCSSGELGVPRAVMTHLSNPRR--------VPPLFERSAAQCW-D 95

  Fly    72 PKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVVDGG---SEDFWRPISSSFSML 133
            |||||.:|||..:...||.::.|:|:.|.|:...:|:|.:||.::..   ..:|..| ::.|.:|
Zfish    96 PKFDSSILEEACRERCFPQMQRRFRYILFYLATAALLWGIYFGINSSRCEPTNFLVP-TAGFLIL 159

  Fly   134 SLVTIMALCFTHWDLYREHRTVTSAVTALLLCGASLAFLTYTGR--------------------- 177
            .||   .|.||....|..:...||.:..:::.|.:||..|.|..
Zfish   160 CLV---LLWFTFTKPYSRYYNHTSFLLTVIMFGITLAPQTQTAHFAHYDSHRADNQSPLPVYQNA 221

  Fly   178 -AFSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIG-CSAIHGGPMHGGGG 240
             ..||:|.|::|:|::||:|:.|.:||:......:.||:.:|.:..:.:. ....:.|...|..|
Zfish   222 SCISPVGTFSLCMEVLLLLYSVLHLPLYASVLLGLLYSVLYEALGWLHLAQLDESYVGSREGISG 286

  Fly   241 AAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQ 305
            .....|      |.      :.:.||..|:||:|:.||:.||.|.||:||||.::..:.||:||.
Zfish   287 TLSWLG------PG------KFLLHLCAHVVGIHIFIMSEVRSRSTFLKVGQAIMHGKDLEVEKA 339

  Fly   306 LKEKMIHSVMPPKVADMLLNEGGPSGLDAG-----------------GLPPESHYMRPRASNDVK 353
            |||:|||||||..|||.|:.:|......:|                 ...|:||..:..:....:
Zfish   340 LKERMIHSVMPRSVADELMKQGDEESESSGKRYSAGTCSVAAAAAVTSSSPKSHKRKKNSIPRGQ 404

  Fly   354 SLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDC 418
            .:||||:|..||.||||||||||||:||:.|:|..||.:|||||.|||.||.|:.||||||||||
Zfish   405 IIFRPFNMKRMEPVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCELTSCEKISTLGDC 469

  Fly   419 YYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDV 483
            ||||:|||||..|||.||||||||||.|:..|..:..|.|.||||||||||||||:|.:|.||||
Zfish   470 YYCVAGCPEPLTDHAYCCVEMGLGMIQAIEQFCQEMSETVNMRVGVHTGTVLCGILGMKRFKFDV 534

  Fly   484 WSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGE--EVFGH---------RTYFVVGRR 537
            |||||:|||.||..|...:||:|:.|:.||.|.|..|:|.  |..||         :||.:.||:
Zfish   535 WSNDVNLANLMEQLGVAGKVHLSEVTAGFLDDRYEREDGRVIERVGHSVTDQLKGLKTYLISGRK 599

  Fly   538 RDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVL 602
                        :.:....|.|.|....|.:||.|:...:....:...|.|
Zfish   600 ------------LGSQCGCSQLSLGQEFGETLSPSSNTHTPDHTHCVIAEP-------------- 638

  Fly   603 SMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQP 667
                             ||..:           ||..|..:                |:|..:.|
Zfish   639 -----------------QSHGK-----------AGFMPCSI----------------SIDVVDNP 659

  Fly   668 PVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEK 732
            ..
Zfish   660 TT--------------------------------------------------------------- 661

  Fly   733 EELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALA 797
                              |...|  |||         :..||..:...||.
Zfish   662 ------------------DEATQ--NGC---------QDEHRANSSKFPAG-------------- 683

  Fly   798 SSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVN 862
                |||:
Zfish   684 ----RSPK--------------------------------------------------------- 687

  Fly   863 GAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVG 927
                                                    |.|.|      .||.|....|.|
Zfish   688 ----------------------------------------TLNGL------LSPLCEERVGVS-- 704

  Fly   928 GGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSIS 992
                       |||:| .....||                                 .|...|::
Zfish   705 -----------QSSLC-DKLQEKD---------------------------------RSWAGSLA 724

  Fly   993 NLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVK 1057
            ..|:.....|||.                       .:..|::||...:..::::: ..:.|..|
Zfish   725 AEGKDHSAILPLR-----------------------SKNFREKSDAHFVEVIKEDS-LMKDYFFK 765

  Fly  1058 PPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPP--TLATPRYNTYIDIFVGIAVYLCISVSL 1120
            ||:.|.||.|..:.||..:|:..|    |......|  |.|:|.:::.:|:.:...|:|.::::.
Zfish   766 PPINKLSLNFLEKSLESAYRTSYH----EQVMNHVPVQTFASPVFSSLLDVLLSCTVFLALTMAC 826

  Fly  1121 FLMTQNTVSPSFRLWVTLFSCFTG--IQVFALFLFTRQM-CRRQSGSNVSNRFRSKSTTSEDLER 1182
            ||..  .||....|..||....|.  :::.:|.|..|.: |                  .:|:
Zfish   827 FLYP--LVSMQTPLAATLGLAITAALLELVSLLLSIRMIFC------------------LDDV-- 869

  Fly  1183 DERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLI---IANFLLLDLEQLEAFEY 1244
                         ::|:..:.:.:|.|.|.|:..|||:::|.:.:   :|..|.|.::
Zfish   870 -------------QNCSRILLKLVSGWVPRHVIGAVLVSLPAVSVFSHLAYSLQLPIQ------- 914

  Fly  1245 HYGFLIFVC------IVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQDQ-- 1301
               ..:|:|      |:.:|.|.||:.|:|:.||.:..|..:      :::||.:......|.
Zfish   915 ---VTMFLCCALIIAIIQYCTFCQLSFWMRSALATVVGLSLL------ILLYSASIRTSATDAFP 970

  Fly  1302 ---EASNFIQEIKWFQDYH----------VEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVAN 1353
               ..||...::....:.:          :|..|...|:|:||||||||||:.|||.::||..|:
Zfish   971 NFGNMSNQSAQVDLLGESNSAPTALDLLVLETVLSFFLLLLLVWFLNREFEVSYRLHYHGNVEAD 1035

  Fly  1354 QDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAKYSENHHNIAIIFASIVNFNEMYDESYLGGKE 1418
            :.::::|.|::|||.||.||||.||||.||....||:||.|:.:||||||||:|.|:|||.||||
Zfish  1036 KHRIKIQTMRDQADWLLRNIIPIHVAEQLKVNQSYSKNHDNVGVIFASIVNFSEFYEESYEGGKE 1100

  Fly  1419 FLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGDE---------HIHTLM 1474
            ..||||||||||||||.:|.|..||||||||:|:||||||:      |.:         |:..|.
Zfish  1101 CYRVLNELIGDFDELLRQPAFSNVEKIKTIGATYMAASGLN------GQQCQEQPHPHAHLCALF 1159

  Fly  1475 EFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPN 1539
            :|::.|..|||.|||::|.|...||||.|.|.:|||||||:||.||||||.||:||||||||:..
Zfish  1160 DFALEMMRVVDDFNKNMLGFKFKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTGVEC 1224

  Fly  1540 RIQVGKD--CLPFLTNRYEFEPRGSVYVKGKDHMEVFLYTTRRDNPLDDDEADKVEQLGTKKMEH 1602
            ||||.::  |:....| |.|:.||:|.||||..|..:|:....:..:
Zfish  1225 RIQVSEESHCVLSRMN-YAFDYRGTVNVKGKGQMRTYLFPQMNEGGM------------------ 1270

  Fly  1603 EGRDEDVVQGEQQAEDKDEEEEEEEEDDDLHSSETTTLFKSQESLQANGGSHLAPNAAATSHTHT 1667
             |..:.:.||:                  :.|.|.:||                  |..|:.||.
Zfish  1271 -GSTQSLEQGQ------------------VDSLEPSTL------------------ANTTTPTHA 1298

  Fly  1668 ITL-TNNNNHNSSNINNN 1684
            ..| ..:|:.|:::|:.:
Zfish  1299 APLIPPSNSPNAASISGH 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	131/232 (56%)
		Guanylate_cyc	361..535	CDD:278633	114/184 (62%)
		CYCc	1362..1556	CDD:214485	119/204 (58%)
		Guanylate_cyc	1388..1575	CDD:278633	113/197 (57%)
adcy9	XP_003201145.2	CYCc	337..570	CDD:214485	132/232 (57%)
		Guanylate_cyc	412..597	CDD:278633	114/184 (62%)
		CYCc	1044..1244	CDD:214485	120/206 (58%)
		Guanylate_cyc	1070..1262	CDD:278633	113/198 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594614
Domainoid	1	1.000	222	1.000	Domainoid score	I2532
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H868
Inparanoid	1	1.050	728	1.000	Inparanoid score	I605
OMA	1	1.010	-	-		QHG49383
OrthoDB	1	1.010	-	-		D207369at33208
OrthoFinder	1	1.000	-	-		FOG0006877
OrthoInspector	1	1.000	-	-		otm25663
orthoMCL	1	0.900	-	-		OOG6_106616
Panther	1	1.100	-	-	LDO	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5766
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910