DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and gucy1b1

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001238874.1	Gene:	gucy1b1 / 100150304	ZFINID:	ZDB-GENE-090313-160	Length:	608	Species:	Danio rerio

Alignment Length:	219	Identity:	64/219 - (29%)
Similarity:	114/219 - (52%)	Gaps:	38/219 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 RQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMH 362
            |.||.||:..:::::||:||.||:.|.::                              ||....
Zfish   381 RALEDEKKKTDRLLYSVLPPSVANELRHK------------------------------RPVPAK 415

  Fly   363 SMENVSILFADIVGF----TRMSSTKTAEQLVEILNDLFERFDDLCSLSG---CEKISTLGDCYY 420
            ..:||:|||:.||||    ::.:|.:.|.::|.:|||::.|||.|.....   ..|:.|:||.|.
Zfish   416 RYDNVTILFSGIVGFNAFCSKHASAEGAIKIVNLLNDIYTRFDILTDSRKNPYVYKVETVGDKYM 480

  Fly   421 CVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWS 485
            .|||.|||...||.....:.|.|::........ .:.|::.:|:|||.|:.|::|.|..::.::.
Zfish   481 TVSGLPEPCTHHAKSICHLALDMMEIAGQVKVD-EDPVQITIGIHTGEVVTGVIGQRMPRYCLFG 544

  Fly   486 NDVSLANKMESSGKPEQVHISQET 509
            |.|:|.::.|::|:..::::|:.|
Zfish   545 NTVNLTSRTETTGEKGKINVSEYT 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	61/215 (28%)
		Guanylate_cyc	361..535	CDD:278633	50/156 (32%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
gucy1b1	NP_001238874.1	HNOB	2..166	CDD:285002
		HNOBA	207..406	CDD:285003	11/24 (46%)
		CYCc	385..584	CDD:214485	61/215 (28%)
		Guanylate_cyc	412..605	CDD:278633	50/158 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810