DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac13E and adcy8

DIOPT Version :9

Sequence 1:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001137224.1	Gene:	adcy8 / 100148976	ZFINID:	ZDB-GENE-070912-197	Length:	1225	Species:	Danio rerio

Alignment Length:	1721	Identity:	390/1721 - (22%)
Similarity:	595/1721 - (34%)	Gaps:	645/1721 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RQSVSSRAMPPGVLVNDSRANS-TDDIQIALAPHIQTYLSQTGRRHSCCSVMLPVAFERAAAKSW 69
            |.|||.|....|..|...|::| ...:||..||....:....|  ::...|:.|.
Zfish    78 RTSVSDRHNNGGTKVFPERSSSDLGFLQIDCAPSNSDFFLSWG--YTYRGVIFPT---------- 130

  Fly    70 LDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVVDGGSEDFWRPISSSFSMLS 134
            |...|.|..||..||.                          ||:   |..   |......::|.
Zfish   131 LRYAFKSRDLERLYQR--------------------------YFL---GQR---RKSVVVMNILD 163

  Fly   135 LVTIMALCFTHWDLYREHRTVTSAVTALLL----------CG--------ASLAFLTY------- 174
            :||.:.|...|..|   ..|....:..:||          |.        :|..:|.|
Zfish   164 VVTKLTLLVLHLTL---ASTPMDPIKGMLLGFFTGIEVVICALVVVRKDTSSHGYLQYSGAVTWV 225

  Fly   175 --------TGRAFSPLGH-FAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAI 230
                    ||..:..||. ....|..:...|:.||:||        :::|...:::      ||:
Zfish   226 AMATQILATGLGYGLLGDGIGYVLFTLFATYSMLPLPL--------TWAIVAGLLT------SAL 276

  Fly   231 HGGPMHGGGGAAGGSGMEANGDPSNRI----LILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVG 291
            |             ..::....|..:|    |:.:::..|.::..|:.:..::....|..|::..
Zfish   277 H-------------IALQLLVPPRAQISTNQLLAQVLLFLCINTAGMFISYLSDRAQRQAFLETR 328

  Fly   292 QNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLF 356
            :.:..|.:||.|.|.:|:::.||:|..|...::|:                 |.......::..|
Zfish   329 RCIEARLRLETENQRQERLVLSVLPRFVVLEMIND-----------------MTNVEDETLQHQF 376

  Fly   357 RPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYC 421
            ...::|..|||||||||:.|||.:|:|.:|::||.:||:||.|||.|.....|.:|..|||||||
Zfish   377 HRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYC 441

  Fly   422 VSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSN 486
            |||.||||.|||.|||||||.||..:|...::....:.||:|:|:|:||||::|.|:.:|||||.
Zfish   442 VSGLPEPRPDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSW 506

  Fly   487 DVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGR-RRDFTRTNSLSPSM 550
            ||.:|||:||.|.|.::|||:.....|...|.:|||.           |: |.||.|.:::...:
Zfish   507 DVDIANKLESGGIPGRIHISKAALDCLNGDYEVEEGH-----------GKDRNDFLRRHNIETFL 560

  Fly   551 PANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKM 615
            ......|.|.||
Zfish   561 IKQPEESLLTLP----------------------------------------------------- 572

  Fly   616 RKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPP 680
                    .|:.|                                 ||..|
Zfish   573 --------EDIMR---------------------------------DSTNQ-------------- 582

  Fly   681 AAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEE 745
             ::.|:                   :|.|...|:.|                .||..||.:..:.
Zfish   583 -SDHRT-------------------SNTSFTEGTWS----------------PELPFHNIVGKQN 611

  Fly   746 TLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSG 810
            |||.:.....|       .||     ||..|.|.:
Zfish   612 TLAALTRHSIN-------LLP-----NHLAQALHV------------------------------ 634

  Fly   811 GGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRA 875
                                              |:||.......|||..:            |:
Zfish   635 ----------------------------------RAGSQEINARMQSTIAL------------RS 653

  Fly   876 GTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQS 940
            |..                                                          .||.
Zfish   654 GDK----------------------------------------------------------LRQE 660

  Fly   941 SICP-SATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPL 1004
            .|.| |.|.|:                  ||.:...||.|...:.::...:...|..:.|:
Zfish   661 HISPFSLTFRE------------------ALLEHKYSQMRDEVFKSNLVCAFIVLFFITGI---- 703

  Fly  1005 AVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKP-PLRKFSLYFK 1068
                           |...|.|..:..|.:.|.|.|:.|......:...|...| .|||...:..
Zfish   704 ---------------QSLLPSARMVTMLIQFSVLILLHCCLVVVTTAEDYKCLPLVLRKACCWVN 753

  Fly  1069 SRQLERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCISVSLFLMTQNTVSPSFR 1133
                        ..:.|.|                :.||:.|.:....::...|......|.|||
Zfish   754 ------------ETYAARN----------------VVIFLSILINFLAAMINILWCDFDKSGSFR 790

  Fly  1134 LWVTLFSCFTGIQVFAL----FLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPH 1194
              ...|:....|.....    |:||                                    |...
Zfish   791 --NQTFNASASIPDICFYPEYFVFT------------------------------------GVLA 817

  Fly  1195 FESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCN 1259
            ..:||  :|..::|         ||....:|::||.:.:|    .|||
Zfish   818 MVTCA--VFLRLNS---------VLKLAILLIMIAIYAVL----TEAF----------------- 850

  Fly  1260 FTQLNCWVR-NVLAFLAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLD 1323
            :|.|  ::| :.|....:..|:|...:.|::
Zfish   851 YTPL--FIRYDTLTLNQSKSFLGTKETSLLL---------------------------------- 879

  Fly  1324 LLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL-----K 1383
            :.:.|:.|::..::.|...||.|.....|.::...::.::...:.:|.||:|.|||.|.     .
Zfish   880 MAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMRELREHNENMLRNILPSHVARHFLEKDRD 944

  Fly  1384 NTAKYSENHHNIAIIFASIVNFNEMYDESYLG--GKEFLRVLNELIGDFDELLSRPEFRAVEKIK 1446
            |...||:::..:.::||||..|.:.|.::.:.  |.|.||:|||:|.||||||....|:.:||||
Zfish   945 NEELYSQSYDTVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEERFQDIEKIK 1009

  Fly  1447 TIGSTFMAASGLDPSHRGTGDE--HIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTA 1509
            |||||:||.|||.|..:...|:  |:..|.:|:||:.|.:...||.... |..|||||..|.|.|
Zfish  1010 TIGSTYMAVSGLSPEKQQCEDKWGHLCALADFAIALNESIQEINKHSFN-NFQLRIGMAHGSVVA 1073

  Fly  1510 GVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNR-YEFEPRGSVYVKGKDHME- 1572
            ||||..|..|||||..||:||||||||:..:||:.::....|..| :.||.||.:||||....|
Zfish  1074 GVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETYAILNERGFAFEYRGEIYVKGISEQEG 1138

  Fly  1573 ----VFLYTTRRDNPLDDDEADKVEQLGTKKMEHEGRDEDVVQGEQQAEDKDEEEEEEEEDDDLH 1633
                .|:....:.|||         .|..:|:..:.....||.|..|:.::.::::      .|:
Zfish  1139 KIRTHFMIGRVQPNPL---------ILQPRKLTGQYSLAAVVLGLVQSLNRQKQKQ------ILN 1188

  Fly  1634 SSETTTLFKSQESLQANGGSHLAPNAAATSH 1664
            .:..:.:.|.    ..|..:.|||..:.|||
Zfish  1189 ENNNSGIMKG----HYNRRTLLAPGGSDTSH 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	94/215 (44%)
		Guanylate_cyc	361..535	CDD:278633	88/173 (51%)
		CYCc	1362..1556	CDD:214485	89/203 (44%)
		Guanylate_cyc	1388..1575	CDD:278633	89/196 (45%)
adcy8	NP_001137224.1	AC_N	<135..374	CDD:292831	56/317 (18%)
		CYCc	340..538	CDD:214485	94/214 (44%)
		Guanylate_cyc	379..563	CDD:278633	93/194 (48%)
		DUF1053	592..685	CDD:283888	36/272 (13%)
		CYCc	919..1123	CDD:214485	89/204 (44%)
		Guanylate_cyc	948..1147	CDD:278633	90/199 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910