Protein Alignment Ac13E and adcy7

DIOPT Version :9

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_001106549.1
• Gene: adcy7 / 100127741
• XenbaseID: XB-GENE-1005225
• Length: 1061
• Species: Xenopus tropicalis
• Alignment Length: 1576
• Identity: 341/1576 - (21%)
• Similarity: 545/1576 - (34%)
• Gaps: 616/1576 - (39%)

  Fly    76 SPVLEEQYQASVFPHVRMRYRFTLSYILL------CSLMWCLYFVVDGGSEDFWRPISSSFSMLS 134
            ||.|.|:||.       :...:.|..|||      |..:..|:|..   |::.:|.:  :|.:..
 Frog    18 SPSLYEKYQC-------ISQHYPLLLILLFVVGASCVTLIVLFFTF---SQEPFRHL--AFIITV 70

  Fly   135 LVTIMALCFTHWDLYREH-----RTVTSAVTALLLCGASLAF-LTYTGRAFSPLGHFAICLEIVL 193
            .|.::..|..:..:|.|.     ..|.|.|  :.:|..::.: |||..............|.|..
 Frog    71 FVALVVFCALYILVYTESFVQKWLRVFSLV--IYICLLTIGYVLTYDSSVVHAWDQVPFFLFITF 133

  Fly   194 LIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRIL 258
            .:||.||    ||....:..|| ...:||:::....:                :.::|  ||..:
 Frog   134 SVYTMLP----LGMQACLIVSI-ISGISHIIVISITV----------------VLSSG--SNDAI 175

  Fly   259 ILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQN-------------LLVRRQLEMEKQLKEKM 310
            ..::||:..:.|.|      ||:   |.:.|....             :.::.:||::|:.:|.:
 Frog   176 AFQLMANAVIFLCG------NLM---GAYHKYHMQDASRDLYSYTVKCIRIKMKLELKKRQQESL 231

  Fly   311 IHSVMPPKVA--------DMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENV 367
            :.||:|..::        |.|               .|::..| :..|:..||:...|    :||
 Frog   232 LLSVLPVYISMEMKLAIQDRL---------------TETNDNR-QPDNNFHSLYVKRH----QNV 276

  Fly   368 SILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADH 432
            |||:||||||||::|..:.::||.:||:||.:||.:...:.|.:|..||||||||||.|....::
 Frog   277 SILYADIVGFTRLASDCSPKELVVMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPVSLPNN 341

  Fly   433 AICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESS 497
            |..||:|||.:.:|::.........:.||||||:|.||||::|.|:.:|||||:||||||:|||:
 Frog   342 AKNCVKMGLDICEAIKQVREATGADINMRVGVHSGNVLCGVIGLRKWQFDVWSHDVSLANRMESA 406

  Fly   498 GKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLP 562
            |.|.:|||::.|...:..||.:|||.           |..||        |.:
 Frog   407 GLPGRVHITEATLKHMNGAYDVEEGH-----------GELRD--------PYL------------ 440

  Fly   563 GAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVE 627
                                           ..:|....|.:.||        .|.|:.::..:.
 Frog   441 -------------------------------KEMNIKTFLVIDPR--------AKNSRVKNNHLT 466

  Fly   628 RGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKV 692
            |   |....||      :.||.:.:|
 Frog   467 R---HRVNDGI------KVRPSVRMT--------------------------------------- 483

  Fly   693 WKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNG 757
                |:|:         |.|
 Frog   484 ----RYLE---------SWG--------------------------------------------- 490

  Fly   758 NGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSM 822
                                    ||||..|...|.
 Frog   491 ------------------------AARPFSHFDQTD----------------------------- 502

  Fly   823 YDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQS 887
                                                                  .|.|..|.
 Frog   503 ------------------------------------------------------ASSTEVPT--- 510

  Fly   888 PLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDS 952
                      ..|:|.|.             :|..|
 Frog   511 ----------VNGKPKPE-------------IPLKG----------------------------- 523

  Fly   953 GIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPAC 1017
                             :.:|..::..||
 Frog   524 -----------------MGRTVKTERNVS------------------------------------ 535

  Fly  1018 SSQMADPLAACLQQLRKQSDL--QLIRCVRDNARSQRSYLVK-PPLRKFSLYFKSRQLERDFRSK 1079
                        |:..::.:|  :::..: |...|.:.:..| .....|.|:|.:..||:::|
 Frog   536 ------------QKRNQEEELHDRMMNTI-DGLSSAKPWFGKTDDFYGFLLFFTADGLEKEYR-- 585

  Fly  1080 AHRFGAENETEGPPTLATPRYNTYIDIFVGIAVYLCI-SVSLFLMTQN-TVSPSFR------LWV 1136
                          |...|...:|  ......::||| .:.:.:|.:: .:..||.      |||
 Frog   586 --------------TFRIPCIQSY--FLCASLIFLCIFLIQILVMPRSANLGISFGVVSVLILWV 634

  Fly  1137 TLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESCADR 1201
            .|. |:.            ..|.|....|                      ||     |......
 Frog   635 LLI-CYV------------DKCARFCNEN----------------------AP-----FSRFLCS 659

  Fly  1202 IFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDL-------------EQLEAFEYHYGFLIFVC 1253
            :.|.|.:.....:.|..|....:|:|....|.||.             .|.::..|:    ::.|
 Frog   660 LVEMIETRPSLRVPLVALTLGSLLIISIVNLPLDQTLQTCNTSSIATESQCQSIPYY----VYCC 720

  Fly  1254 IVHF--CNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQDQEASNFIQEIKWFQDY 1316
            |:..  |:.....|:...:|...||.    .|.:.::.::|:...:.....:...:::.:....:
 Frog   721 ILGLVACSMFLRMCFELKILLLTAAF----TAYNVIIFHTHSSIFRSNLNSSIGVLEDFQKMSCF 781

  Fly  1317 HVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVA-- 1379
            ::.:|   .|.|||   |.|:.|...||.........::...::.|:|...:||.|::|.|||
 Frog   782 YLSLY---YLTLVL---LARQVEYYSRLDCLWKRKFRKEDEEIETMENLNQLLLENVLPAHVAAY 840

  Fly  1380 ---EHLKNTAKYSENHHNIAIIFASIVNFNEMYDESYLG--GKEFLRVLNELIGDFDELLSRPEF 1439
               ::..|...|.:::..:.::|||:..|...|.|..:.  |.|.||:|||:|.||||||.:|:|
 Frog   841 FIDDNRSNEDLYHQSYDCVCVMFASVPEFKVFYTECDVNKEGLECLRLLNEIIADFDELLMKPKF 905

  Fly  1440 RAVEKIKTIGSTFMAASGL--DPSHRGTGDEHIHTL----MEFSIAMQEVVDAFNKDLLEFNLIL 1498
            ..||||||||||:|||:||  .|.......|..|.|    :|:::|:...:|..|:.... |..|
 Frog   906 SGVEKIKTIGSTYMAATGLTATPGQENQDQEKQHALIGITVEYAMALMSKLDGINRHSFN-NFRL 969

  Fly  1499 RIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTN-RYEFEPRGS 1562
            |:|:|.|.|.|||||..|..|||||:.|||||||:|||...:|||.::....|.. .|..|.||.
 Frog   970 RVGINHGPVIAGVIGAKKPQYDIWGNTVNVASRMESTGELGKIQVTEETCQILEGLGYSCECRGF 1034

  Fly  1563 VYVKGKDHMEVFLYTT 1578
            :.||||..:..:...|
 Frog  1035 INVKGKGELRTYFVCT 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	89/223 (40%)
		Guanylate_cyc	361..535	CDD:278633	80/173 (46%)
		CYCc	1362..1556	CDD:214485	88/207 (43%)
		Guanylate_cyc	1388..1575	CDD:278633	86/195 (44%)
adcy7	NP_001106549.1	AC_N	<21..266	CDD:318454	60/306 (20%)
		Guanylate_cyc	268..418	CDD:306677	76/153 (50%)
		DUF1053	483..591	CDD:399378	34/448 (8%)
		Guanylate_cyc	851..1048	CDD:306677	86/197 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910