Protein Alignment Ac13E and adcy9

DIOPT Version :10

• Sequence 1: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_031748711.1
• Gene: adcy9 / 100126441
• XenbaseID: XB-GENE-999257
• Length: 1369
• Species: Xenopus tropicalis
• Alignment Length: 1683
• Identity: 512/1683 - (30%)
• Similarity: 726/1683 - (43%)
• Gaps: 558/1683 - (33%)

  Fly    57 LPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVVDGGSED 121
            ||..|||:.:: |.:|||||..|||......||..:.|:|:.|.|:.:..|:|.:||.|...|:
 Frog   131 LPQLFERSTSR-WWNPKFDSNNLEEACVERCFPQTQRRFRYALMYLSVAGLLWSIYFSVHMKSK- 193

  Fly   122 FWRPISSSFSMLSLVTIMA--LC----------FTHWDLYREHRTVTSAVTALLLCGASLA---- 170
                         ||:.:|  ||          ||....|..|.|..|.:..||:...:||
 Frog   194 -------------LVSHLAPTLCFLIVCLGFFSFTFTKSYARHCTAISLLVTLLVFALTLASQFQ 245

  Fly   171 ----------FLTYT-------GRAFSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFE 218
                      .|..|       ....|.:|.|:||:|::||:||.:.:||:|.|...::|||.||
 Frog   246 VLSPGLVSDSLLNLTSSTATDFSSCLSQVGSFSICVEVLLLLYTVMHLPLYLSACLGVAYSILFE 310

  Fly   219 MVSHMVIGCSAIH------GGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLI 277
            ...:        |      .||:         .|..|:.:     |:.:.:.|:.:|.:|||:.|
 Frog   311 TFGY--------HFRDERCFGPL---------VGRMAHWE-----LLSKALLHICIHAIGVHLFI 353

  Fly   278 MNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDA----GGLP 338
            |:.||.|.||:||||:::..:.||:||.|||:|||||||..:||.|:.:|.....::    ....
 Frog   354 MSEVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDDESENSVKRHSASS 418

  Fly   339 PESHYMRPRASNDVKS--LFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFD 401
            |:|   |.:.|:..|:  :||||.|..:|.||||||||||||:||:.|:|..||.:|||||.|||
 Frog   419 PKS---RKKKSSIQKTPIIFRPFKMQRIEQVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFD 480

  Fly   402 DLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHT 466
            .||..:.||||||||||||||:||||||.|||.||:|||||||:|:..|..::.|.|.|||||||
 Frog   481 RLCEETKCEKISTLGDCYYCVAGCPEPRPDHAYCCIEMGLGMIEAIEQFCQEKKEMVNMRVGVHT 545

  Fly   467 GTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEE---------- 521
            |||||||:|.||.|||||||||:|||.||..|...:||||::|:.:|.|.|.:|:
 Frog   546 GTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEKTARYLDDRYLMEDSMVVERLGQI 610

  Fly   522 --GEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVP 584
              .:::.|.:|:.:.|||          |.:| :.:.|..|||...||.||.            |
 Frog   611 VAADQLKGLKTFLISGRR----------PRVP-SCSCSQTLLPIQEGADLSS------------P 652

  Fly   585 PASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPK 649
            ..:|.||.:.|
 Frog   653 ALAPHGQTAPS------------------------------------------------------ 663

  Fly   650 IIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGS 714
                           |....|.| ||....|                      |.|.:..|||
 Frog   664 ---------------ETSAASDP-LPNCTQP----------------------EILKSCPSCG-- 688

  Fly   715 SSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLD 779
                                          ||
 Frog   689 ------------------------------ET--------------------------------- 690

  Fly   780 IPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFG 844
              |||.                 .||.|||...|
 Frog   691 --AARD-----------------GPEEGVSTANG------------------------------- 705

  Fly   845 RSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEP 909
                                   |...|.:.|.  |.||.....|..|..|             |
 Frog   706 -----------------------GGSEEWKGGA--TRPPSIAXSLKDPERS-------------P 732

  Fly   910 GPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTA 974
            .|||                         :.::..|..|..|. ::...|...:     :::|:|
 Frog   733 EPSS-------------------------EDTLTNSQASLYDM-LQEKGRWCGV-----SMDQSA 766

  Fly   975 ISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQ 1039
            :                          |||.                       .:.:|:::|..
 Frog   767 L--------------------------LPLR-----------------------FKNIREKTDAH 782

  Fly  1040 LIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGP-PTLATPRYNTY 1103
            .:..::::: ..:.|..|||:...||.|..::||..:|..   :..|.....| .|.|:.::::.
 Frog   783 FVEVIKEDS-LMKDYFFKPPINPLSLNFLDKELETSYRGS---YQEEVLRMAPVKTFASAKFSSL 843

  Fly  1104 IDIFVGIAVYLCISVSLFLMT-QNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVS 1167
            :|:.:...:::.:||:.||.. .:.|||.....|.|..|  |:..|...|.:.:|
 Frog   844 LDVLLCFFIFILLSVACFLKPGTDPVSPPTLALVLLSVC--GLLGFLSLLVSVRM---------- 896

  Fly  1168 NRFRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFL 1232
                  :...||:               ..|..|:.|.||.|.|.|....||:.:|. .::.::|
 Frog   897 ------TFYLEDM---------------LLCTRRLLEIISGWLPRHFIGTVLVCLPA-AVVFSYL 939

  Fly  1233 LLDLEQLEAFEYHYGFLIFVC------IVHFCNFTQLNCWVRNVLAFLA-----ALCFIGIAVSQ 1286
            ..|      |..:..:.:|:|      :|.:|||.||:.|:|:.||.:|     .|.::.:...:
 Frog   940 SSD------FYTNIHYTMFLCSALLIPMVQYCNFCQLSSWLRSSLATIAGATMLTLLYLPLCPEK 998

  Fly  1287 LM----------VYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNREFEIG 1341
            |.          :.:.|.|.:.:|...:.|.     |.....||.:...|:|:||||||||||:.
 Frog   999 LRLAPETDIEGNMSTSNSSFEAEDNARTEFP-----FTLLGQEIAVAYFLLLLLVWFLNREFEVS 1058

  Fly  1342 YRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTAKYSENHHNIAIIFASIVNFN 1406
            |||.::|:..|:..:.::|:|::|||.||.||||.||||.||.:..||:||.:..:||||||||:
 Frog  1059 YRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQSYSKNHDDAGVIFASIVNFS 1123

  Fly  1407 EMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPS--------HR 1463
            |.|:|:|.||||..|||||||||||||||:|.:..:|||||||:|:||||||:||        ||
 Frog  1124 EFYEENYEGGKECYRVLNELIGDFDELLSKPHYSCIEKIKTIGATYMAASGLNPSQCQDSSQPHR 1188

  Fly  1464 GTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNV 1528
                 |:.||.||:..|..|||.||.::|.||..||||.|.|.:|||||||:||.||||||.||:
 Frog  1189 -----HLQTLFEFAKEMMSVVDDFNNNMLWFNFKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNI 1248

  Fly  1529 ASRMDSTGLPNRIQVGKDCLPFLTNR-YEFEPRGSVYVKGKDHMEVFLYTTRRDN---------- 1582
            |||||:||:..|||..::....|... |:|:.||:|.||||..|:.:|:....||
 Frog  1249 ASRMDTTGVECRIQASEESYRVLVKMGYDFDYRGTVNVKGKGQMKTYLFPKCTDNGGLVPHHQLS 1313

  Fly  1583 -----------PLDDDEADKVEQLGTKKMEHEGRDEDVVQGEQQAEDKDEEEEEEEED 1629
                       .:.....|::..|.|     .|:.. |..|..:|..|.|:.||...|
 Frog  1314 ISPDIRVQVDGSIGRSPTDEISSLVT-----AGKGA-VDSGSGEAGRKREKAEERGRD 1365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	130/221 (59%)
		PHA03307	836..>1015	CDD:223039	22/178 (12%)
		Guanylate_cyc	1388..1575	CDD:425528	112/195 (57%)
adcy9	XP_031748711.1	AcyC	226..631	CDD:441717	188/439 (43%)
		Guanylate_cyc	438..626	CDD:425528	110/187 (59%)
		Guanylate_cyc	1105..1297	CDD:425528	112/196 (57%)