DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gmap and TRIP11

DIOPT Version :9

Sequence 1:	NP_001356946.1	Gene:	Gmap / 32483	FlyBaseID:	FBgn0027287	Length:	1401	Species:	Drosophila melanogaster
Sequence 2:	NP_004230.2	Gene:	TRIP11 / 9321	HGNCID:	12305	Length:	1979	Species:	Homo sapiens

Alignment Length:	2037	Identity:	411/2037 - (20%)
Similarity:	754/2037 - (37%)	Gaps:	705/2037 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SWL--------------NSSLSQLKGQLTNLAQEVLAETAGPGDLEYEGHQAGGASVQDAEQQAK 52
            |||              ..||:.|.||::|..:::|.|    |..|.|      |.:.|:..:..
Human     3 SWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLME----GTEEVE------AELPDSRTKEI 57

  Fly    53 TALELLAETQEQKEQLDKRC---EEKDR--EIAALRRELAKSKQKQESQLAASTSATREPQLQNE 112
            .|:.  |..:.:.|:|.|.|   |||..  ||...::..:...|.|:.::..|....|:..||::
Human    58 EAIH--AILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQ 120

  Fly   113 EPNVEDSWCWEPDGGDEKGATGAGS-------GDSASRDKESGLVDIALGNDDVVRLNNRIAELE 170
            ...::.:....|.|......|.:.|       ..||..|.:....||.....::.||:|.::.||
Human   121 LLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLE 185

  Fly   171 -------QLNEQLNVSLEELDSQHELAMRDVLEHKTQLAGQVASLKQLQADRLVEHE-----LSN 223
                   .:.:.......:...|.|:.         :|...:..|||.::..:.:|:     |.|
Human   186 SEVGHWRHIAQTSKAQGTDNSDQSEIC---------KLQNIIKELKQNRSQEIDDHQHEMSVLQN 241

  Fly   224 ARQQKQLDEL----RQTSSAAKKQQEELQRRVEQQEAELIEMQDLLDK--RRQDTAELIERVRVA 282
            |.||| |.|:    |:..|..:::.|||:..::|..:.:||..  |.|  ..|.|.::::..:|.
Human   242 AHQQK-LTEISRRHREELSDYEERIEELENLLQQGGSGVIETD--LSKIYEMQKTIQVLQIEKVE 303

  Fly   283 ETERERLLKDLEETRQAKEKKTSESSSNSSSTGKHSEDEFIVVRQ-ADATGSGSASGSDRDPDAD 346
            .|::   ::.||:..:...||.|.:.::.....:..|...:..|| .:...:.....|...|.|.
Human   304 STKK---MEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAV 365

  Fly   347 VTSPPSKEKLRDRLVSLESQISELTLANTQLQDAQLE-KQLSI----NMLGEQLVELEKRLRLSE 406
            ..|....||  :|:::..:.:.|:......|.||:.| .:||.    |.|.|..::|:.|:.:.|
Human   366 KQSDTMTEK--ERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLE 428

  Fly   407 -------AEKEQLQVNLQLRLQ--------------QLTVQNQELKLHAEAEQEGHAQNLEE--- 447
                   .|||:||::| |:|.              .|..:..:|:|:.||:::...|::.|
Human   429 KEKSLLSQEKEELQMSL-LKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKET 492

  Fly   448 ---QLGDLREDNQRLRQE---LKTSIAQ---------AKFRQAIAEEKQEITDLDDADSEYGTFE 497
               ::.:|...||...:.   :|..:::         :|.:|.:.:||:.:..|:| |....|.|
Human   493 LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLED-DKMDITKE 556

  Fly   498 LD-KLRALLQAEI------------EDRLDSSFPQ--------------------------QKLE 523
            || :...|:|:|:            ||::::...|                          ::|.
Human   557 LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS 621

  Fly   524 RAWNAL------------KDRWHRLDLVEQRLVDVQN-QQLVSEHEK-----KTLEADI----SQ 566
            |..|.|            ||     .|:::|..:|:| :|.:||.|:     |.:..|:    .:
Human   622 RIRNELMQSLNQDSNSNFKD-----TLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEK 681

  Fly   567 YILQCDE--------LMKNNDL----------------------------LLNELDKYK------ 589
            .:|.|::        |..||.|                            ||.|.:||:
Human   682 LVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEEL 746

  Fly   590 --------------------------------RNKLETIEEHHEETIVQLEAQLEEARQKLEL-- 620
                                            :..:|.::..|:||...|.:.|||.:|..:|
Human   747 SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLIN 811

  Fly   621 -----------------------------------------ASLSSQQQMETHL----------- 633
                                                     .||.|.::...||
Human   812 KKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQ 876

  Fly   634 -----ISSPEKTPVDSELLAK---------------------MEQKEQEYLQLQEQLAFAKTELD 672
                 ::.|:.....:||.::                     :|.:.|..:||.:.|...|.|:|
Human   877 SRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD 941

  Fly   673 K-------------------------RNKLLERNGEQLTKQQQQNQAD------QKKLEELS--- 703
            :                         ..|.:|:...||.:::|..|.|      :.|::.|:
Human   942 EFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIEN 1006

  Fly   704 -------------QLRETLQRRDEDLKEL-EEQLSAVRQ-------------------DLDEKSI 735
                         :|.:.::.|:.::|.| |:.:|..:|                   ||:.:::
Human  1007 GSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQAL 1071

  Fly   736 QMKISQDQHKLQLANLQNQLQA---DQEKL----------------------------------- 762
            ..:||...|...:..||.||||   ::||:
Human  1072 HARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKL 1136

  Fly   763 ----------------------------------------------------------------- 762

Human  1137 QDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNS 1201

  Fly   763 ---RELLQLQDKLEQQKELMEVDQNQQITIIKK---ELAETTNQLSECQERLTVKE--------- 812
               .||||.:|||:||.:.||..:.|.:|.::.   |.|:...:|.:.|.::.|..
Human  1202 NQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVD 1266

  Fly   813 -------------------AQLAEIQQQL------------------------------------ 822
                               .:||::|..:
Human  1267 YTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLR 1331

  Fly   823 ---QEVNEERTRLQEQLLTKEQESGLDSE-----LAKRNQELEDQLLA----KEQQLQLNQAELE 875
               .||..|.:.|.:|.|.:.::|..:.:     |.:.|..|.|.:.|    :.::.:...:|::
Human  1332 ASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIK 1396

  Fly   876 KLQETLRVNEEQLLAKEEQLHAKESQLQSLESQLQGQLAADESQQLQQTIDGL-----------G 929
            :|:|...|.::.|..|:..:.||..||.|.......::  :|::.|:|.:..|           |
Human  1397 QLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKV--NENELLRQAVTNLKERILILEMDIG 1459

  Fly   930 QEKNELIKVLQQKHQENTQYYAEIQRLQPFEQQVKE-----------------LVKEREK----- 972
            :.|.|..|:::....:.|:|.|..:....|...::|                 |:||:|:
Human  1460 KLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGE 1524

  Fly   973 ----------LQDQVGFLKEKSDILTTNLLTEQTNQRLLQQQQAESQEQQASTLRDLERLRAHLL 1027
                      :|::....:::.|.:...|..:|.....||.:....::::..:.::|||||.|||
Human  1525 LNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLL 1589

  Fly  1028 EIEELHTQETVELQRDLEESRSRQAILEQQVSKSSTAYTSASIRANQQAETLQAQHALLQQQRDE 1092
            |.|:.:|:|.:..:....:.|.:..:||:::..||.|..:||.:|:.|.|:||.|..::.:||||
Human  1590 ESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDE 1654

  Fly  1093 LLAKLGQYEDRELKQQA-ALTNLQCALEQFQNDKDHDIEMATQRIRREMQAQLDRQGQLQLE--- 1153
            ...:|...:: ::||.| :|.|||..||.||.::           :....|:|::|.||..|
Human  1655 TALQLSVSQE-QVKQYALSLANLQMVLEHFQQEE-----------KAMYSAELEKQKQLIAEWKK 1707

  Fly  1154 --------MSGLQQQLAEANQGLRAAARLSDQLEAGQQTIAVLRDEVESLKEANGQLEQRLSSSE 1210
                    :..||:.|.|||..|.:|:||::||:..::.|..|:.:.|..:|....::::|.|..
Human  1708 NAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLA 1772

  Fly  1211 SSQTDKIDKSLIKSLLIGYVVSGHA--GDKQQVLRMISSVLDFNAQEA------DKVGLNKQQSS 1267
            :|...|:||.|:::|.||:.   |.  ..:.:|||::.|:|....:|.      |:.|:.:..:.
Human  1773 NSSEGKVDKVLMRNLFIGHF---HTPKNQRHEVLRLMGSILGVRREEMEQLFHDDQGGVTRWMTG 1834

  Fly  1268 WLGAILGGGSATASAA----GSSRGNENLVQAFVQFLEQESQPQAQSRPTL-------LSMTGQM 1321
            |||   ||..:..:..    ..|..|.:..:.||:|||.||.|.... |.|       |...|:.
Human  1835 WLG---GGSKSVPNTPLRPNQQSVVNSSFSELFVKFLETESHPSIPP-PKLSVHDMKPLDSPGRR 1895

  Fly  1322 DGVTSA--SATTSTAATSGHLPQASSSFSPATPAASQQDPA--APRTPPVGGSPQLLAMGSNEFA 1382
            ...|:|  |...:..:.||.....:...:|.:.|....:||  .|     ||...||....::..
Human  1896 KRDTNAPESFKDTAESRSGRRTDVNPFLAPRSAAVPLINPAGLGP-----GGPGHLLLKPISDVL 1955

  Fly  1383 PT---------RNSSSILKDIL 1395
            ||         .::..:|||:|
Human  1956 PTFTPLPALPDNSAGVVLKDLL 1977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gmap	NP_001356946.1	Smc	161..983	CDD:224117	242/1394 (17%)
Gmap	NP_001356946.1	SMC_prok_A	799..>1185	CDD:274009	112/516 (22%)
TRIP11	NP_004230.2	Amphipatic lipid-packing sensor required for tethering of intra-Golgi vesicles. /evidence=ECO:0000269\|PubMed:25473115	2..38		9/34 (26%)
		Smc	306..>1075	CDD:224117	135/780 (17%)
		PRKG1_interact	603..682	CDD:292521	16/83 (19%)
		SMC_prok_B	908..1752	CDD:274008	166/857 (19%)
		Involved in RAB2A binding. /evidence=ECO:0000269\|PubMed:25473115	1017..1195		20/177 (11%)
		Involved in RAB2A binding. /evidence=ECO:0000269\|PubMed:25473115	1325..1599		57/275 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1873..1920		10/47 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159537
Domainoid	1	1.000	239	1.000	Domainoid score	I2278
eggNOG	1	0.900	-	-		E1_28JI4
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3354
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007277
OrthoInspector	1	1.000	-	-		oto91328
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18921
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5725
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.010