DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gmap and Trip11

DIOPT Version :9

Sequence 1:	NP_001356946.1	Gene:	Gmap / 32483	FlyBaseID:	FBgn0027287	Length:	1401	Species:	Drosophila melanogaster
Sequence 2:	NP_082722.1	Gene:	Trip11 / 109181	MGIID:	1924393	Length:	1976	Species:	Mus musculus

Alignment Length:	1797	Identity:	436/1797 - (24%)
Similarity:	734/1797 - (40%)	Gaps:	512/1797 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NSSLSQLKGQLTNLAQEVLAETAGPGDLE---YEGHQAGGASVQDAEQQAKTALELLAETQEQKE 66
            :|.:.:::..:..|..|.:..|....|||   .|.|:...::..|.|...|....|..|.:|..|
Mouse   284 HSKVYEMQNTIQILQMEKVESTKQIEDLENKIKEIHKRLSSAEHDQEVWKKEQERLEVEKREMTE 348

  Fly    67 QLDKRCEEKDREIAALRRELAKSKQKQESQLAASTSATREPQLQNEEPNVEDSWCWEPDGGDEKG 131
            |    ||.       |:.||:::   |:|.|..|.:|..|..:.....:|.:....:
Mouse   349 Q----CER-------LKLELSEA---QQSALRQSDAAVEEETILPHSSSVAEVLRLQ-------- 391

  Fly   132 ATGAGSGDSASRDKESGLV-------DIALGNDD------VVRLNNRIAELEQLNEQLNVSLEEL 183
                    .|..|.|:.::       ||:|..|:      |..|....:.|.|..|:|.:||.:|
Mouse   392 --------QALTDAENEIMRLRSLNQDISLAEDNQKLQMCVQTLEKEKSLLSQEKEELQISLSKL 448

  Fly   184 DSQHEL----AMRDVLEHKTQLAGQVASLK-QLQADRLVEHELSNARQQK-----QLDEL-RQTS 237
            .|::|:    |.||:     .|..||..|| .|:|.   |.||:.:..:.     :|:|| :|..
Mouse   449 SSEYEVIKSTATRDL-----DLFSQVHDLKHNLEAK---EQELNQSIHENEILMAELEELDKQNQ 505

  Fly   238 SAAK----------KQQEELQRRVEQQEAELIEMQDLLDKRRQDTAELIERVRVAE---TERERL 289
            .|.|          |||.|....:::.:.||...:....:...|...:|:.:.|.:   |..|:.
Mouse   506 EATKHVILIKDQLSKQQSEGDSVIKKLKEELAGEKQRTHQLEDDKMNIIKELTVQKEKLTHSEQA 570

  Fly   290 LKDLEETRQAKEKKT-------SESSSNSSSTGK----------HSEDEFIVVRQADATGSGSAS 337
            |.||:.|:|..|.|.       |:|..|:....|          .:|:|...|| ::.|.| ...
Mouse   571 LSDLQLTKQKLEDKVEDLVDQLSKSEKNNFDIQKENHELREHIRQNEEELSTVR-SELTQS-QTQ 633

  Fly   338 GSDRDPDADVTSPPSKEK------LRDRLVSLESQISE--------LTLANTQLQDA--QLEKQL 386
            ||.|:...|:.    ||:      |:..|..:| |::|        |...|.:|.:|  ::..||
Mouse   634 GSSRNVKDDLL----KERETQVQNLKQNLSEVE-QLNEHLEQVAFDLRTENEELLEAYEEVRNQL 693

  Fly   387 SINMLGEQLVELEKRLRLSEAEKEQLQVNL---------QLRLQQLTVQ---------------N 427
            ..::.|.:.:.|||...| |.||..|:..|         :.|..:.|||               .
Mouse   694 EESVAGNKQISLEKTAML-EWEKAPLETELCRAEKRVLEEERKYEQTVQELSSACSPDTSALQLE 757

  Fly   428 QELKLHAEAEQEGHAQNLEEQLGDLREDNQRLRQELKTSIAQAK-FRQAIAEEKQEITDLDDADS 491
            ||..:....|::.....|::.:..:..|::|.::.|.:|:.:.| ..|.|.|::..|..|.:..|
Mouse   758 QERLIQLNQEKDFEIAELKKSIEQMDTDHKRTKETLSSSLEEQKQLTQLINEKEICIVKLKEKSS 822

  Fly   492 EYGTFELDK----LR--ALLQAEIEDRLDSSFPQQKLERAWNALKDRWHRLDLVEQRLVDV---- 546
            |... ||||    ||  ..|:..||:: |.|....|.|.  |.|::...||...:.|:|..
Mouse   823 ELQK-ELDKCAQTLRKNETLRQTIEEK-DRSLGSMKEEN--NHLQEELERLREQQSRVVPAPEPR 883

  Fly   547 ---QNQQLVSE----------------HEKKTLEADISQYILQCDELMKNNDLLLNELDKYK--- 589
               ...:|.||                |.:|.:| |.:|..||   |:::......|||::|
Mouse   884 TLDSTTELESELSQLHRIKGHLEEEIKHHQKMIE-DQNQSKLQ---LLQSLQEQKKELDEFKYQH 944

  Fly   590 --------RNKLETIEE--HHEETIVQLEAQLEEAR-----------QKLELASLSSQQQMETHL 633
                    |..||..||  :.::||.|::|||.|.|           |:.::.|||.:...|.|.
Mouse   945 EQMSISHTRLFLEKDEEIKNLQKTIEQIKAQLHEERQDSQTENSDIFQETKVQSLSIEHGSEKHD 1009

  Fly   634 ISSPEKTPVDSELLAK-MEQKEQEYLQLQEQLAFAKTELDKRNKLLERNGEQLTKQQQQNQADQK 697
            :|..|     :|.|.| ::::|.|.                  |||......|||     |.||.
Mouse  1010 LSKAE-----TERLVKGIKERELEI------------------KLLNEKNTSLTK-----QIDQL 1046

  Fly   698 KLEELSQLRETLQRRD----------------EDLKELEEQLSAVRQD-------LDEKSIQ-MK 738
            ..:|:.:|.:.:|::|                :|:..|::||.|...:       |:||:.: .:
Mouse  1047 SKDEVGKLTQIIQQKDLEIQALHARISSASYSQDVVYLQQQLHAYAMEREKVMVILNEKTRENSQ 1111

  Fly   739 ISQDQHKL---------QLANLQNQLQ--------ADQEKLRELLQLQDKLEQQKELMEVDQNQQ 786
            :..:.||:         .|..||::.:        :.|:..:|.:|...::.::|:: |:|...|
Mouse  1112 LKTEYHKVIDIISAKEAALIKLQDENKKMSTRFESSGQDMFKETIQNLSRIIREKDI-EIDALSQ 1175

  Fly   787 -----ITIIK------KELAETTNQLSE-CQERLTVKE--AQLAEIQQQ----LQEVNEERTRLQ 833
                 :|:::      :.....:||..| .|||..:|:  .::.|.:||    :|.:..|..:||
Mouse  1176 KCQTLLTVLQTSGTGSEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQ 1240

  Fly   834 EQLLTKEQESGLDSELAKRNQELEDQLLAKEQQLQLNQAELEKL-QETLRV---------NEEQL 888
            |:|...:.:..:||:   .|.:|:.......|..:.|:.:|:.. ||..:|         .::.|
Mouse  1241 EELHQLQAQVSVDSD---NNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLL 1302

  Fly   889 LAKEEQLHAKESQLQSLESQLQGQLAA-------DESQQLQQTIDGLG---QEKNELIKVLQQ-- 941
            |.|.:.:..:.|...||.||....|.|       :.||.|||.:|.|.   |||:..|:.||:
Mouse  1303 LGKLDIMSPQLSSGSSLTSQAAEPLRASQSSEPHESSQLLQQEVDDLRKSLQEKDATIRTLQENN 1367

  Fly   942 -------------KHQENTQYYAEIQRLQPFEQQVKELVKER----------------------- 970
                         :.:|:.|..:||::|:..::.::.|:||:
Mouse  1368 HRLSDSVAASSEVERKEHEQADSEIKQLKEKQEVLQNLLKEKDLLIKAKSDQLHSSNENLANKVN 1432

  Fly   971 --EKLQDQVGFLKEKSDIL-----------------------------TTN-------------- 990
              |.|:..|..|||:..||                             .||
Mouse  1433 ENELLRQAVTNLKERILILEMDISKLKGENEKIVDASKGKETEYQALQETNMKFSMMLREKEFEC 1497

  Fly   991 ------------LLTE-------QTNQRL-----------------------LQQQQAESQ--EQ 1011
                        ||.|       :.||.|                       |:|:|.|:.  :.
Mouse  1498 HSMREKALAFEQLLKEKEQGKAGELNQLLNAVKSMQEKTVTFQQERDQVMLALKQKQMETSTLQN 1562

  Fly  1012 QASTLRD--------LERLRAHLLEIEELHTQETVELQRDLEESRSRQAILEQQVSKSSTAYTSA 1068
            :...|||        |:|||.||||.|:.||:|.:..:....:.|.:.::||:::..||.|..:|
Mouse  1563 EVQRLRDKESRLNQELQRLRDHLLESEDSHTREALAAEDREAKLRKKVSVLEEKLVSSSNAMENA 1627

  Fly  1069 SIRANQQAETLQAQHALLQQQRDELLAKLGQYEDRELKQQA-ALTNLQCALEQFQNDKDHDIEMA 1132
            |.:|:.|.|:||.|..::.:||||...:|...:: ::||.| :|.|||..||.||.::
Mouse  1628 SHQASVQVESLQEQLNMVSKQRDETALQLSVSQE-QVKQYALSLANLQMVLEHFQQEE------- 1684

  Fly  1133 TQRIRREMQAQLDRQGQLQLE-----------MSGLQQQLAEANQGLRAAARLSDQLEAGQQTIA 1186
                :....|:|::|..|..|           :..||::|.|||..|.:|:||::||:..::.|.
Mouse  1685 ----KAMYSAELEKQNHLLAEWKKKAESLEGKVLSLQERLDEANAALDSASRLTEQLDLKEEQIE 1745

  Fly  1187 VLRDEVESLKEANGQLEQRLSSSESSQTDKIDKSLIKSLLIGYVVSGHAGDKQ--QVLRMISSVL 1249
            .|:.:.|..:|.....:::|.|..:|...|:||.|:::|.||:.   |....|  :|||::.|:|
Mouse  1746 ELKKQNELHQEMLDDAQKKLMSLVNSTEGKVDKVLMRNLFIGHF---HTPKHQRHEVLRLMGSIL 1807

  Fly  1250 DFNAQEADKVGLNKQ--QSSWLGAILGGGSATASAA-----GSSRGNENLVQAFVQFLEQESQPQ 1307
            ....:|.:::....|  .:.|:...|||||.:....     ..|..|.:..:.||:|||.||.|.
Mouse  1808 GVKREEMEQLFAEDQGGVTRWMAGWLGGGSKSVPNTPLRPNQQSVFNSSFSELFVKFLETESHPS 1872

  Fly  1308 AQSRPTLLSMTG--QMDGVTSASATT--------STAATSGHLPQASSSFSPATPAASQQDPAAP 1362
            ..  |..||:.|  .:|......|.|        :..:.:|.....:...:|.:.|....:||.
Mouse  1873 VP--PPKLSVHGLKPLDSPGRRKADTGIPESFRDTAESRAGRRTDVNPFLAPRSAAVPLINPAG- 1934

  Fly  1363 RTPPVGGSPQLLAMGSNEFAPT---------RNSSSILKDIL 1395
            ..|  ||...||....::..||         .::..:|||:|
Mouse  1935 HGP--GGPGHLLLKPISDVLPTFTPLPVSPDNSAGVVLKDLL 1974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gmap	NP_001356946.1	Smc	161..983	CDD:224117	260/1076 (24%)
Gmap	NP_001356946.1	SMC_prok_A	799..>1185	CDD:274009	139/559 (25%)
Trip11	NP_082722.1	SMC_prok_B	226..1065	CDD:274008	214/862 (25%)
Trip11	NP_082722.1	Smc	946..1768	CDD:224117	204/865 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849909
Domainoid	1	1.000	247	1.000	Domainoid score	I2147
eggNOG	1	0.900	-	-		E1_28JI4
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3241
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007277
OrthoInspector	1	1.000	-	-		oto94906
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18921
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5725
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.010