DRSC/TRiP Functional Genomics Resources

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Protein Alignment mh and SPRTN

DIOPT Version :9

Sequence 1:NP_573032.1 Gene:mh / 32480 FlyBaseID:FBgn0267977 Length:724 Species:Drosophila melanogaster
Sequence 2:NP_114407.3 Gene:SPRTN / 83932 HGNCID:25356 Length:489 Species:Homo sapiens


Alignment Length:548 Identity:177/548 - (32%)
Similarity:277/548 - (50%) Gaps:97/548 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 IQASHDDYLNKTMNLVDPEWELVDPTPDIYAMFIRFDEKFFQERLGAVSLEWSKKMYSCAGICYQ 160
            :|.:..|:..::::|||..|||||||||:.|:|::|:::||..:|.||.::||.:|..|||||..
Human    17 LQEAERDHAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAGICSY 81

  Fly   161 RGNRFVKQVTIRLSEPLLKLRPRKDLVETLLHEMIHAYCFVLNIREGNGGHGPNFKRIMETINKV 225
            .|..  ...:||||||||||||||||||||||||||||.||.|..:...||||.|.:.|..||.:
Human    82 EGKG--GMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNNDKDREGHGPEFCKHMHRINSL 144

  Fly   226 AGTNITVYHTFHDEVASYRTHIWRCTGICRERSPFWGYVKRTSNRAPGPNDQWWKMHQRECSGTF 290
            .|.||||||||||||..||.|.|||.|.|:.|.|::|||||.:||.|..:|.||..||:.|.||:
Human   145 TGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPYYGYVKRATNREPSAHDYWWAEHQKTCGGTY 209

  Fly   291 LKLSEPPKAPKPETKSRAK-KSTPAVAAPKEDIRNWFGQPSAKKAATGTVLLGDLAKAVPPTSYP 354
            :|:.||....| :.|.:|| ...|.:||..:|..|                .|:....:|     
Human   210 IKIKEPENYSK-KGKGKAKLGKEPVLAAENKDKPN----------------RGEAQLVIP----- 252

  Fly   355 GLSSEPFALPKT---PAAGTKGNKSGGFNELDKSGSKATTEMSGQGYSLGGSSAIEHIDLSDTDV 416
             .|.:.:.|.:|   |:.| |...|...|:        |.::..|.:|   ::|:.         
Human   253 -FSGKGYVLGETSNLPSPG-KLITSHAINK--------TQDLLNQNHS---ANAVR--------- 295

  Fly   417 PDSAKLRQIRLQRFSEDASNKRQNKKKRRRVSSDSEII-NW---ESYDDDVMVRDVH-TPIVNLV 476
            |:|    :|:: :|.::.|:|..:.......:|...:: |:   .|:.:....|.|: :|.:::.
Human   296 PNS----KIKV-KFEQNGSSKNSHLVSPAVSNSHQNVLSNYFPRVSFANQKAFRGVNGSPRISVT 355

  Fly   477 ESSSDEEEMKMPAGRKTMTSQERTQIIK------RQVMEDELTLCEDDILLIDDEYDDEVAANES 535
            ..:       :|....:.:||.|....|      .:|.|....:...|:...:|.:.::      
Human   356 VGN-------IPKNSVSSSSQRRVSSSKISLRNSSKVTESASVMPSQDVSGSEDTFPNK------ 407

  Fly   536 LTAATELADQSIIDDIFGEDTLLKEFQRENDVQPSCS------SYAKRIENDIVSCPICFEKMRR 594
               ...|.|:::.|:.|    :.||..:.:...|..|      |.:...::.:|:||:|..::..
Human   408 ---RPRLEDKTVFDNFF----IKKEQIKSSGNDPKYSTTTAQNSSSSSSQSKMVNCPVCQNEVLE 465

  Fly   595 TELSNHFDGCAIMVRLEPPSFKPKNRRT 622
            ::::.|.|.|     ||..|.|.|:..:
Human   466 SQINEHLDWC-----LEGDSIKVKSEES 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mhNP_573032.1 SprT-like 124..294 CDD:287265 96/169 (57%)
ZnF_Rad18 582..605 CDD:128973 6/22 (27%)
SPRTNNP_114407.3 SprT-like 45..213 CDD:287265 96/169 (57%)
SHP-box. /evidence=ECO:0000269|PubMed:23042605 253..261 1/7 (14%)
PIP-box. /evidence=ECO:0000269|PubMed:22681887, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:27084448 325..332 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 357..409 9/67 (13%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:27852435 402..413 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..453 3/24 (13%)
ZnF_Rad18 453..476 CDD:128973 7/27 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147335
Domainoid 1 1.000 125 1.000 Domainoid score I5511
eggNOG 1 0.900 - - E1_KOG3931
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 255 1.000 Inparanoid score I3190
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1171375at2759
OrthoFinder 1 1.000 - - FOG0007186
OrthoInspector 1 1.000 - - oto90350
orthoMCL 1 0.900 - - OOG6_104384
Panther 1 1.100 - - LDO PTHR21220
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5295
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.760

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