Protein Alignment mh and SPRTN

DIOPT Version :10

• Sequence 1: NP_573032.1
• Gene: mh / 32480
• FlyBaseID: FBgn0267977
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_114407.3
• Gene: SPRTN / 83932
• HGNCID: 25356
• Length: 489
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 177/548 - (32%)
• Similarity: 277/548 - (50%)
• Gaps: 97/548 - (17%)

  Fly    96 IQASHDDYLNKTMNLVDPEWELVDPTPDIYAMFIRFDEKFFQERLGAVSLEWSKKMYSCAGICYQ 160
            :|.:..|:..::::|||..|||||||||:.|:|::|:::||..:|.||.::||.:|..|||||..
Human    17 LQEAERDHAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAGICSY 81

  Fly   161 RGNRFVKQVTIRLSEPLLKLRPRKDLVETLLHEMIHAYCFVLNIREGNGGHGPNFKRIMETINKV 225
            .|..  ...:||||||||||||||||||||||||||||.||.|..:...||||.|.:.|..||.:
Human    82 EGKG--GMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNNDKDREGHGPEFCKHMHRINSL 144

  Fly   226 AGTNITVYHTFHDEVASYRTHIWRCTGICRERSPFWGYVKRTSNRAPGPNDQWWKMHQRECSGTF 290
            .|.||||||||||||..||.|.|||.|.|:.|.|::|||||.:||.|..:|.||..||:.|.||:
Human   145 TGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPYYGYVKRATNREPSAHDYWWAEHQKTCGGTY 209

  Fly   291 LKLSEPPKAPKPETKSRAK-KSTPAVAAPKEDIRNWFGQPSAKKAATGTVLLGDLAKAVPPTSYP 354
            :|:.||....| :.|.:|| ...|.:||..:|..|                .|:....:|
Human   210 IKIKEPENYSK-KGKGKAKLGKEPVLAAENKDKPN----------------RGEAQLVIP----- 252

  Fly   355 GLSSEPFALPKT---PAAGTKGNKSGGFNELDKSGSKATTEMSGQGYSLGGSSAIEHIDLSDTDV 416
             .|.:.:.|.:|   |:.| |...|...|:        |.::..|.:|   ::|:.
Human   253 -FSGKGYVLGETSNLPSPG-KLITSHAINK--------TQDLLNQNHS---ANAVR--------- 295

  Fly   417 PDSAKLRQIRLQRFSEDASNKRQNKKKRRRVSSDSEII-NW---ESYDDDVMVRDVH-TPIVNLV 476
            |:|    :|:: :|.::.|:|..:.......:|...:: |:   .|:.:....|.|: :|.:::.
Human   296 PNS----KIKV-KFEQNGSSKNSHLVSPAVSNSHQNVLSNYFPRVSFANQKAFRGVNGSPRISVT 355

  Fly   477 ESSSDEEEMKMPAGRKTMTSQERTQIIK------RQVMEDELTLCEDDILLIDDEYDDEVAANES 535
            ..:       :|....:.:||.|....|      .:|.|....:...|:...:|.:.::
Human   356 VGN-------IPKNSVSSSSQRRVSSSKISLRNSSKVTESASVMPSQDVSGSEDTFPNK------ 407

  Fly   536 LTAATELADQSIIDDIFGEDTLLKEFQRENDVQPSCS------SYAKRIENDIVSCPICFEKMRR 594
               ...|.|:::.|:.|    :.||..:.:...|..|      |.:...::.:|:||:|..::..
Human   408 ---RPRLEDKTVFDNFF----IKKEQIKSSGNDPKYSTTTAQNSSSSSSQSKMVNCPVCQNEVLE 465

  Fly   595 TELSNHFDGCAIMVRLEPPSFKPKNRRT 622
            ::::.|.|.|     ||..|.|.|:..:
Human   466 SQINEHLDWC-----LEGDSIKVKSEES 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mh	NP_573032.1	SprT	122..292	CDD:214794	97/169 (57%)
		ZnF_Rad18	582..605	CDD:128973	6/22 (27%)
SPRTN	NP_114407.3	SprT	43..212	CDD:214794	97/170 (57%)
		SHP-box. /evidence=ECO:0000269|PubMed:23042605	253..261		1/7 (14%)
		PIP-box. /evidence=ECO:0000269|PubMed:22681887, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:27084448	325..332		1/6 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..409		9/67 (13%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:27852435	402..413		2/19 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..453		3/24 (13%)
		ZnF_Rad18	453..476	CDD:128973	7/27 (26%)