DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mh and Sprtn

DIOPT Version :9

Sequence 1:	NP_573032.1	Gene:	mh / 32480	FlyBaseID:	FBgn0267977	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_006255870.1	Gene:	Sprtn / 292101	RGDID:	1559496	Length:	496	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	182/539 - (33%)
Similarity:	258/539 - (47%)	Gaps:	102/539 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 IQASHDDYLNKTMNLVDPEWELVDPTPDIYAMFIRFDEKFFQERLGAVSLEWSKKMYSCAGICYQ 160
            :||:......:.::|||..|||||||||:.|:|::|:::||..:|.||.::||.:|..|||||..
  Rat    17 VQAARRAAAREPLSLVDASWELVDPTPDLQALFLQFNDRFFWGQLEAVEVKWSVRMTLCAGICTY 81

  Fly   161 RGNRFVKQVTIRLSEPLLKLRPRKDLVETLLHEMIHAYCFVLNIREGNGGHGPNFKRIMETINKV 225
            .|..  ...:||||||||||||||||||||||||||||.||.|..:...||||.|.:.|..||::
  Rat    82 EGRG--GMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNNDKDREGHGPEFCKHMHRINQL 144

  Fly   226 AGTNITVYHTFHDEVASYRTHIWRCTGICRERSPFWGYVKRTSNRAPGPNDQWWKMHQRECSGTF 290
            .|.||||||||||||..||.|.|||.|.|:.:.|::|||||.:||||..:|.||..||:.|.||:
  Rat   145 TGANITVYHTFHDEVDEYRRHWWRCNGPCQHKQPYYGYVKRATNRAPSAHDYWWADHQKTCGGTY 209

  Fly   291 LKLSEPPK-APKPETKSRAKKSTPAVAAPKEDIRNWFGQPSAKKAATGTVLLGDLAKAVPPTSYP 354
            :|:.||.. |.|...|::|.|...:....|:.:.....||....:..|.| |||.:..
  Rat   210 IKIKEPENYAKKGRGKTKAGKQPTSAVENKDKLCRGEAQPLIPFSGKGYV-LGDTSTC------- 266

  Fly   355 GLSSEPFALPKTPAAGTKGNKSGGFNELDKSGSKATTEMSGQGYSLGGSSAIEHIDLSDTDVPDS 419
                        |:|| |.|.|...|:        |..:|||.:|..|.....::::
  Rat   267 ------------PSAG-KLNTSHMVND--------TKGLSGQDHSASGLKLDSNVEV-------- 302

  Fly   420 AKLRQIRLQRFSEDASNKRQNKKKRRRVSSDSEIINWESYDDDVMV------RDVH-TPIVN--- 474
             |..|..|       .||:.:.......:|...:::  ||...|.|      |:|: :|:.:
  Rat   303 -KCEQNGL-------PNKKPHLVTPLPTASHQSVLS--SYFPRVSVANQKAFRNVNGSPVKSGTI 357

  Fly   475 --LVESSSDEEEMKMPAGR--------------KTMTSQERTQIIKRQVMEDELTLCEDDILLID 523
              ...|:|...:.|:|..|              .|:||...|.    ..:..|.:..||..|...
  Rat   358 DGTKHSASAGAQRKVPPSRASLRNSSKVTAPASATVTSAAGTS----AAISREESGSEDQFLNKR 418

  Fly   524 DEYDDEVAAN---ESLTAATELADQSIIDDIFGEDTLLKEFQRENDVQPSCSSYAKRIENDIVSC 585
            ...:|..|.|   |...:..:|.|.|                |...:....||..:|   .:|:|
  Rat   419 PRLEDRTALNNIKEQTQSGGDLEDSS----------------RPTAISTPRSSGGQR---RLVNC 464

  Fly   586 PICFEKMRRTELSNHFDGC 604
            |:|...:..::::.|.|.|
  Rat   465 PVCQGVVLESQINEHLDRC 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mh	NP_573032.1	SprT-like	124..294	CDD:287265	96/169 (57%)
mh	NP_573032.1	ZnF_Rad18	582..605	CDD:128973	7/23 (30%)
Sprtn	XP_006255870.1	SprT-like	45..213	CDD:287265	96/169 (57%)
Sprtn	XP_006255870.1	ZnF_Rad18	461..484	CDD:128973	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340986
Domainoid	1	1.000	126	1.000	Domainoid score	I5313
eggNOG	1	0.900	-	-		E1_KOG3931
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171375at2759
OrthoFinder	1	1.000	-	-		FOG0007186
OrthoInspector	1	1.000	-	-		oto97466
orthoMCL	1	0.900	-	-		OOG6_104384
Panther	1	1.100	-	-	LDO	PTHR21220
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750