DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mh and dvc-1

DIOPT Version :9

Sequence 1:	NP_573032.1	Gene:	mh / 32480	FlyBaseID:	FBgn0267977	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001369944.1	Gene:	dvc-1 / 179554	WormBaseID:	WBGene00011834	Length:	368	Species:	Caenorhabditis elegans

Alignment Length:	387	Identity:	165/387 - (42%)
Similarity:	210/387 - (54%)	Gaps:	57/387 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 NLVDPEWELVDPTPDIYAMFIRFDEKFFQERLGAVSLEWSKKMYSCAGIC-YQ-RGNRFVKQVTI 171
            :||||.:||.||.|||:|:||:||.:||...|....::||.:||:||||| |: ||.| ....:|
Worm     5 SLVDPSFELSDPCPDIHALFIQFDARFFGGSLACCEVKWSPRMYACAGICSYEIRGGR-GGLCSI 68

  Fly   172 RLSEPLLKLRPRKDLVETLLHEMIHAYCFVLNIREGNGGHGPNFKRIMETINKVAGTNITVYHTF 236
            |||:|||.||||.||||||||||||||.||........||||.|:..|..||:..|||||:||:|
Worm    69 RLSKPLLTLRPRSDLVETLLHEMIHAYLFVKERNRDRDGHGPQFQAHMHRINQAGGTNITIYHSF 133

  Fly   237 HDEVASYRTHIWRCTGICRERSPFWGYVKRTSNRAPGPNDQWWKMHQRECSGTFLKLSEPPKAPK 301
            ||||..|:.|.|||:|.||:|.||:|||||:.||||||||:||..||:.|.|.|||:.|
Worm   134 HDEVRLYKQHWWRCSGPCRDRRPFFGYVKRSCNRAPGPNDRWWSQHQQSCGGNFLKVKE------ 192

  Fly   302 PETKSRAKKSTPAVAAPKEDIRNWFGQPSAKKAAT-GTVLLGDLAKAVPPTSYPGLSSEPFALPK 365
            ||...:.|.|      .:.:.:|..|.|:.||..| ..|.|.|..|.....|....:|:....|.
Worm   193 PEGYGQGKGS------KRTNDKNKSGGPALKKTITPPRVTLDDFFKKDGKNSSDNSTSKSPTKPS 251

  Fly   366 TPAAGTKGNKSGG---FNELDKSGSKATTEMSGQGYSLGGSS--------------------AIE 407
            |......|.|.||   .:.|..|..|| |:.|| |..|||:|                    |.:
Worm   252 TSLFTGSGQKLGGSSSTSSLLNSYPKA-TQNSG-GNRLGGTSGGVSRLLPPVNFTSPSSAPVAEQ 314

  Fly   408 HIDLSDTDVPDSAKLRQIRLQRFSEDASNKRQNKKKRRRVSSDSEIINWESYDDDVMVRDVH 469
            .|||.|:|..|        .|...:||       .:...|:||:.:| ..|.:.:||...:|
Worm   315 VIDLGDSDDDD--------FQDMDDDA-------LEISFVASDNSVI-CPSCNTEVMENLIH 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mh	NP_573032.1	SprT-like	124..294	CDD:287265	102/171 (60%)
mh	NP_573032.1	ZnF_Rad18	582..605	CDD:128973
dvc-1	NP_001369944.1	SprT	18..190	CDD:214794	103/172 (60%)
dvc-1	NP_001369944.1	ZnF_Rad18	345..367	CDD:128973	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159464
Domainoid	1	1.000	121	1.000	Domainoid score	I3545
eggNOG	1	0.900	-	-		E1_KOG3931
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H102024
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007186
OrthoInspector	1	1.000	-	-		oto19199
orthoMCL	1	0.900	-	-		OOG6_104384
Panther	1	1.100	-	-	LDO	PTHR21220
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3918
SonicParanoid	1	1.000	-	-		X5295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.770