DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mh and sprtn

DIOPT Version :9

Sequence 1:	NP_573032.1	Gene:	mh / 32480	FlyBaseID:	FBgn0267977	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001106631.1	Gene:	sprtn / 100127870	XenbaseID:	XB-GENE-5845785	Length:	436	Species:	Xenopus tropicalis

Alignment Length:	519	Identity:	162/519 - (31%)
Similarity:	245/519 - (47%)	Gaps:	113/519 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 MNLVDPEWELVDPTPDIYAMFIRFDEKFFQERLGAVSLEWSKKMYSCAGICYQRGNRFVKQVTIR 172
            :::|||.|||:||.|||.|:|:.|::.||..:|..:.::||.:|..|||:|...|...:  .:||
Frog     3 LSVVDPTWELLDPNPDIRALFLEFNDTFFWGQLSGIEVKWSARMTLCAGVCSYEGRGGL--CSIR 65

  Fly   173 LSEPLLKLRPRKDLVETLLHEMIHAYCFVLNIREGNGGHGPNFKRIMETINKVAGTNITVYHTFH 237
            |||||||||||||||:|||||||||..||.:..:.:..|||.|.:.||.|||..|.||:|||.||
Frog    66 LSEPLLKLRPRKDLVQTLLHEMIHALLFVTHNNKDHDSHGPEFCKHMERINKRTGANISVYHNFH 130

  Fly   238 DEVASYRTHIWRCTGICRERSPFWGYVKRTSNRAPGPNDQWWKMHQRECSGTFLKLSEPPKAPKP 302
            |||..||.|.|.|.|.|::|.|::|||||..||||...|.||..|||.|.|.|:|:.|      |
Frog   131 DEVDEYRKHWWLCNGPCQKRKPYFGYVKRAMNRAPSSLDPWWADHQRTCGGEFVKIKE------P 189

  Fly   303 ETKSRAKKSTPAVAAPKEDIRNWFGQPSAKKAATGTVLLGDLAKAVPPTSYPGLSSEPFALPKTP 367
            |..|:.:|            ||                 .|     |..|..|.||.
Frog   190 ENYSQKRK------------RN-----------------ND-----PTKSELGNSSH-------- 212

  Fly   368 AAGTKGNKSGGFNELDKSGSKATTEMSGQGYSL---GGSSAIEHIDLSDTDVPDSAKLRQIRLQR 429
               .|.|| |..|.:|   .:.....||.||.|   ..|.|...|. :|....|.|      :..
Frog   213 ---VKINK-GKSNGVD---IRTVIPFSGTGYKLFEPSKSDAQLKIQ-NDNPTKDKA------VMH 263

  Fly   430 FSEDASNKRQNKKKRRRVSSDSEIINWESYDDDVMVRDVHTPI-VNLVESSSDEEEMKMPAGRKT 493
            .:..::|:..:....|::.|..:|            ...:|.: :||     :...:|:|:....
Frog   264 HTPPSTNQTDSTFLSRKIVSAKKI------------SVANTKVFINL-----NGSPIKLPSSSNN 311

  Fly   494 MTSQERTQIIKRQVMEDELTLCEDDILLIDDEYDDEVAANESLTAATELADQS---------IID 549
            .:.|:.::  ::.|:....|..::.|        |..::::|..:.::..::.         .:|
Frog   312 KSHQDSSK--QKSVLHFFKTQKDNSI--------DLTSSSQSFPSTSQGPNREETEHFYKKLQMD 366

  Fly   550 DIFGEDTLLKEFQRENDV-----QPSCSSYAKRIENDI----VSCPICFEKMRRTELSNHFDGC 604
            |...:||.:.....:.:|     ..||:..|..|.:.:    |.||:|..::..:::::|.|.|
Frog   367 DKESKDTFIIHSLNKTNVSDSLNNKSCAGPAATINSGLNHTKVCCPVCGTEIFESKINDHLDTC 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mh	NP_573032.1	SprT-like	124..294	CDD:287265	91/169 (54%)
mh	NP_573032.1	ZnF_Rad18	582..605	CDD:128973	7/27 (26%)
sprtn	NP_001106631.1	SprT-like	19..127	CDD:370932	56/109 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..219		17/86 (20%)
		SHP-box. /evidence=ECO:0000250\|UniProtKB:Q9H040	231..239		4/7 (57%)
		PIP-box. /evidence=ECO:0000250\|UniProtKB:Q9H040	271..277		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..321		3/22 (14%)
		ZnF_Rad18	408..431	CDD:128973	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5941
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171375at2759
OrthoFinder	1	1.000	-	-		FOG0007186
OrthoInspector	1	1.000	-	-		oto104156
Panther	1	1.100	-	-	LDO	PTHR21220
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3918
SonicParanoid	1	1.000	-	-		X5295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.050