DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip128 and Grip163

DIOPT Version :9

Sequence 1:	NP_573030.2	Gene:	Grip128 / 32478	FlyBaseID:	FBgn0026433	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_648537.2	Gene:	Grip163 / 39365	FlyBaseID:	FBgn0026432	Length:	1351	Species:	Drosophila melanogaster

Alignment Length:	834	Identity:	163/834 - (19%)
Similarity:	280/834 - (33%)	Gaps:	270/834 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KTSTAVNSAINENVRKLVRSL--SEPGTSQKKLRQMEDTALKIIANQRRTWAPTTTDMEVKRNLD 78
            |..|||  .:.:...|:..||  ||..:||.||..:.....::..|..|        |::.....
  Fly    30 KKQTAV--LVAKKRSKIYESLLHSETMSSQDKLEMLHQVTSEVAKNPDR--------MDMLLRFQ 84

  Fly    79 DLAERFRAEGMASFGESIKDLAIRYLAMDENQQQFNPNPGWQMLELLFRIADRPVQ---KIRLNR 140
            :|.|          |:..::..|.....:|||.:.          ::.||...|:|   .|.:..
  Fly    85 NLLE----------GQDKEESEITQDQDEENQSEV----------VIKRIKAGPLQLIETIEIVE 129

  Fly   141 EFMEQRRLSIINSMEEAERQAQIEEQAKLEAAKNTSETEVDWAALLSEDFLDPPEDDSSDSLSDW 205
            |.:..:....||.|..|.:..|::..:.:....|           |:.:|  |||......:
  Fly   130 EALHPKAFPDINQMNRALKPLQLQPYSDILTTSN-----------LNINF--PPEKLIPKII--- 178

  Fly   206 SEESDCDSTTTLKPDENIGVSRSLLEMARVYEQAMMAVVPTGSVNKTYMPPEQSVIRSYDFRIMK 270
                   .:|.::    :|:|.|:..|....|:.|            :.||...|       :.|
  Fly   179 -------PSTVIR----MGLSESITRMRNEMEKPM------------HPPPRLPV-------LAK 213

  Fly   271 PTVLSLNNLKGSHLRRSKLLQLPPPQPPRPFTQYWQSGNTDTLFRKIHSHWWCQDVHLNALPSSA 335
            ..|..|.:      .|..:.|   |.|.:.|.......|...:.|.       :::.||.|..:
  Fly   214 KVVAPLED------ERPFVAQ---PGPEKHFVSDKLLTNELKILRN-------KNLVLNYLDEA- 261

  Fly   336 KPLDNFAVSYVQFLNHNARGL--LALPV-----------PKTITEPCLLREILF----MFVRPAS 383
                    :.:..|...|.|:  |..|:           |.| |.|.:|.|:|.    .|:| |.
  Fly   262 --------TLIDHLKKAACGIESLTFPISSADKLELRVRPNT-TLPTMLPEVLADFANHFIR-AG 316

  Fly   384 CCFFEFDKATR-----------------RITVRDNVSICTVTASTMQNFLLFDVVPALEDMMELR 431
            |.|......|:                 |.|:.|.:       ||.:.|||.....:|
  Fly   317 CAFLRLSSRTKWNNIAEMRLERPLNRAMRETIMDYL-------STTRQFLLSLQADSL------- 367

  Fly   432 HIIDTHTLHFHGVKTTYTVEFFAYGLRDLVQPICQLLIAYEDRV-NKDPAKNTLIRFTIEFREHF 495
                     |..:..|.|.          :|.:|||     ||: ..:|..|.....|..|
  Fly   368 ---------FQLLNNTSTA----------IQLLCQL-----DRMFENEPRLNLNTGITGSF---- 404

  Fly   496 SQLRLLRE--LAEDVILDKGPAHIRSAYL--LSRLYKHTLLQVPHQKLATALLFISLKRYCIIID 556
                ||..  ||.|...:|...|:...:|  :||.|                 ||.|:|
  Fly   405 ----LLSSIWLAIDTCGNKDFLHLLIYFLRCISRNY-----------------FIQLQR------ 442

  Fly   557 GWWRRAALEDHLREFIVEFCYEEDANTRSHVRK----RNMGMEDDLL---LVEIFNKLQSCPLYQ 614
             |.....|::.:.|..:..|.....:..:...|    ::..::::.:   ||....::..|..|.
  Fly   443 -WIYHGELDESVNEIFISRCLNTSPSFTNQCSKEFFDKSYQVDNEAIPEFLVGCEEEILQCGKYN 506

  Fly   615 LLL-----EHALESGETQDLL----------------------------CSVNTLSE--MLT--- 641
            |:|     :|.:...:..|::                            ||:.::.|  |.|
  Fly   507 LVLRAYNAQHPVFDVQYPDIVVCLTEQQLKNMRRNLADKYAIIYKRFGWCSMQSIFEDRMATKRV 571

  Fly   642 -SNNEIQLPSLHDELFTQFFAQLKVYCGADNTDYEDE--PEPDKDYEDLTVCNRQGIRNHELFAI 703
             :|..::....|.:.:.|...:|::...|......|:  .|.::..::.....||.|.|...|..
  Fly   572 FANLMVKRTQAHLDAWAQKQRELQIKANAQKKLQNDQLNAEQERIQQNHLEKRRQDIVNELAFQR 636

  Fly   704 FTQPLVEQRLERQRERLKSNPVLMANILKRL-ERSTCLQLK----SELPEALRE 752
            ..:.:.::.|||:::.|:...|.:|.:|... :|||...|.    .|.|:.|.|
  Fly   637 ECERMEDKLLEREKQELQKKVVQLAAVLSSSPDRSTVSDLSFASCIEEPDCLAE 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip128	NP_573030.2	Spc97_Spc98	373..>580	CDD:282045	49/232 (21%)
Grip163	NP_648537.2	Spc97_Spc98	266..>536	CDD:282045	68/341 (20%)
		AP1AR	583..>709	CDD:292373	26/108 (24%)
		Spc97_Spc98	<949..1245	CDD:282045
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455387
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110079at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19302
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.040