DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip128 and Tubgcp6

DIOPT Version :9

Sequence 1:	NP_573030.2	Gene:	Grip128 / 32478	FlyBaseID:	FBgn0026433	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_001156791.1	Gene:	Tubgcp6 / 328580	MGIID:	2146071	Length:	1769	Species:	Mus musculus

Alignment Length:	1233	Identity:	206/1233 - (16%)
Similarity:	381/1233 - (30%)	Gaps:	453/1233 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 QKKLRQMEDTALKIIANQRRTWAPTTTDMEVKRNLDDLAERFRAEGMASFGESIKDLAIRYLAMD 107
            :|:|| ||....::|.:.|..         ..|.|.:|::|..||               .:|.|
Mouse   659 EKELR-MEIAKQELIVHAREA---------ASRVLSELSDRQMAE---------------QIAQD 698

  Fly   108 -ENQQQFNPNPGWQMLELLF------RIADRPVQKIRLNREF--------MEQRRLSIINSMEEA 157
             ..::||      |.|:..|      |:|.|..:   |:.:|        .|:|..::...:|..
Mouse   699 TRKREQF------QRLKEQFVKDQERRLAARQEE---LDDDFSYARELRDREKRLKALEEELERK 754

  Fly   158 ERQAQIEEQAKLEAAKNTSETEVDWAALLSEDFLDPPEDDSSDSLSDWSEESDCDSTTTLKPDEN 222
            .|||.::..:||.|.....|.:..|.
Mouse   755 ARQALVDHYSKLSAEAARREQKALWR--------------------------------------- 780

  Fly   223 IGVSRSLLEMARVYEQAMMAVVPTGSVNKTYMPPEQSVIRSY--DFRIMKPTVLSLNNLKGSHLR 285
              :.|..||.||:                .::..:|..|:..  |....:|
Mouse   781 --IQRHRLESARL----------------RFLLEDQKCIQEMLRDMEAQQP-------------- 813

  Fly   286 RSKLLQLPPPQPPRPFTQYWQSG--------NTDTLFRKIHSHWWCQDVHLNALPSSAKPLDNFA 342
                 |.||...|...:|...:|        :.|..|.::  ||.|..:...:.||..|.....|
Mouse   814 -----QEPPSVFPSTGSQVTSTGPEHAGEGHSCDPGFTEL--HWGCPSLPCASTPSVPKSATEGA 871

  Fly   343 -----------VSYVQFLNHNARGLLALPVPKTITEPCLLREILFMFVRPASCCFFEFDKATRRI 396
                       :|...|          |||.....:|.....:.|:.|...:.|      :....
Mouse   872 DDSGAGPFSTGLSITDF----------LPVDSGEEQPVENTGVPFLEVALQTIC------SDLSP 920

  Fly   397 TVRDNVSICTVTASTMQNFLLFDVV--PALEDMM------ELRHIIDTHTLHFHGVKTTYTVEFF 453
            ...:..::........|:...|:.:  ||:...:      ::::.:|:...|..|..:| .|:.:
Mouse   921 VAPEPAALTAGGPQATQSEYDFNTILRPAMATSLSPGPFQDVQNSVDSDKQHLLGDMST-KVDSY 984

  Fly   454 AYGLRDL----------------VQPICQLLIAYEDRVNKDPAKNTLIRFTIEFREHFS------ 496
            .:.:::.                :||:.|||             ..:...|:....|.|
Mouse   985 IHDMQETLPCPHPLSHATPVEGSLQPVGQLL-------------EHMSETTVSTESHASGMAPCQ 1036

  Fly   497 QLRLLRELAE----------DVILDKGP-----AHIRSAYL------------LSRLYKHTLLQV 534
            ||.:.|.:::          ||.|.: |     .|:..|.:            ..|...|..:..
Mouse  1037 QLSISRHVSDANIKVGDYMSDVALPR-PRWNVHGHVSEASIGVGENMAEVAPSRPRWNVHGHVSD 1100

  Fly   535 PHQKLATALLFISLKRYCIIIDG----------------------W------------------- 558
            ...|:...:..::..|....|.|                      |
Mouse  1101 ASIKIGENMSDVAPSRTRWNIHGHVSDASIKVGENVSDVTPSRPRWNVHGHVSEASIKVGENVSD 1165

  Fly   559 -------WRRAALEDHLREFIVEFCYEEDA----------NTRSHVRKRNMGMEDDLLLVEIFNK 606
                   |.   :..|:.|..::  ..|:.          |...||...::.:.:::...::..:
Mouse  1166 VTPSRPRWN---VHGHVSEASIK--VGENVSDVTPSRPRWNVHGHVSDASIRIGENVSDTDLDLQ 1225

  Fly   607 LQSCPLYQLLLEHALESGETQDL---LCSVNTLSEMLTSNNEIQLPSLHDELFTQFFAQLK--VY 666
            .:.|....|:||..|...|. ||   .|....:||.:. ..|.|.|:|  |...|...:.|  |.
Mouse  1226 QRGCAQPPLILEEPLPEAEA-DLKPHQCPPAHVSEAVL-GVEAQSPAL--ECGPQLPEKTKPTVC 1286

  Fly   667 CGADNTD---------------------YEDEPEPDKDYEDLTVC-------------------- 690
            .|...|:                     .|..|...:|.|||:.|
Mouse  1287 SGFGRTEEGSLQTKTLVAEPSMLGSGIPEEKGPGKSRDAEDLSPCLPSSSQEDTAVPSSPGPSDE 1351

  Fly   691 --------NRQG--------------------------------IRNHEL---FAIFTQPLVEQR 712
                    .|.|                                :.:|.|   ||....|.|:..
Mouse  1352 VSNTEAEARRWGKEQAYLTDLTKLYHLEQYPDSYDSMSEPPVAHLVHHMLPRAFAFPVDPQVQSA 1416

  Fly   713 LER---QRERLKSNPVLMANILKRLERSTCLQLKSELPEALREILRRRQWLANEYAIRAYCKETQ 774
            ::.   |...|.:.||||       :||....|.:.:.            |.::.|:..:..|..
Mouse  1417 VDESAVQLSELLTLPVLM-------KRSLMAPLAAHVS------------LVSKAAVDYFFVELH 1462

  Fly   775 VAEKMRFLRHTMLLEKYYLFVPYYNALFVRM-------EKNNSWALGSVLTSKLCAVL---LPHY 829
            :......|||.:|:|.........:.||.::       |..|...|.|:|:..|...|   .||.
Mouse  1463 LETHFEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNSILSKALQYSLHGDTPHA 1527

  Fly   830 PQLAHYLHVKLISQINSNSIKVYEALEAIELDFERPMAMHQWYILTPAHMQDYNSVWRLMLKVKW 894
            ..|:..|  |.:.::.:.:..  :.|..:||.::....::  .::|.:.:..|:.::..:|::|.
Mouse  1528 SNLSFAL--KYLPEVFAPNAP--DVLSCLELRYKVDWPLN--IVITESCLNKYSGIFSFLLQLKL 1586

  Fly   895 AVWKLENMQF-LRRARFNPCAPLDLIGLT-----IRRLEIVRFWLIFLINNLHAHIMEAVSR--- 950
            .:|.|:::.| |:|..        |:..|     .|:|::.:..:...:..:..:|...:..
Mouse  1587 MMWTLKDICFHLKRTA--------LVSHTAGSVQFRQLQLFKHEMQHFVKVIQGYIANQILHVSW 1643

  Fly   951 -QFELRIGECKNVRELRIMHDEHLAWLKTHCMLTDEFKAFRVALDQIFHLV-----YVLDMEW 1007
             :|..|:....::.|::..|.|:|.......:||::.......:..||.||     .::...|
Mouse  1644 CEFRARLAVVGDLEEIQRAHAEYLHRAVFRGLLTEKAAPVMNIIHSIFSLVLKFRSQLISQNW 1706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip128	NP_573030.2	Spc97_Spc98	373..>580	CDD:282045	39/311 (13%)
Tubgcp6	NP_001156791.1	Spc97_Spc98	355..>611	CDD:282045
		NBP1	<622..>752	CDD:285709	27/126 (21%)
		ARGLU	631..759	CDD:291991	30/133 (23%)
		Ehrlichia_rpt	672..1249	CDD:118064	112/724 (15%)
		DUF4200	689..785	CDD:290574	27/160 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..842		7/51 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..881		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1284..1360		10/75 (13%)
		Spc97_Spc98	<1403..1667	CDD:282045	57/296 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110079at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010