Protein Alignment Grip128 and Tubgcp5

DIOPT Version :10

• Sequence 1: NP_573030.2
• Gene: Grip128 / 32478
• FlyBaseID: FBgn0026433
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: XP_063118388.1
• Gene: Tubgcp5 / 308663
• RGDID: 1304689
• Length: 1025
• Species: Rattus norvegicus
• Alignment Length: 1262
• Identity: 228/1262 - (18%)
• Similarity: 443/1262 - (35%)
• Gaps: 423/1262 - (33%)

  Fly     1 MAPPAQKGNLRKRSGKTSTAVNSAINENVRKLVRSLSEPGTSQKKLRQMEDTALKII-----ANQ 60
            ||.|...|:...|.          :..:||:|||.::       .|:...|:..::.     :|.
  Rat     1 MARPKSSGSRMDRQ----------LEHDVRELVRQVT-------GLQDEADSNFQMALDFAWSNF 48

  Fly    61 RRTWAPTTTDMEVKRNLDDLAERFRAEGMASFGESIKDLAIRYLAMD-ENQQQFNPNPGWQMLEL 124
            |..........:|::.::.:.|:.......|...|.|.|...:|.:. .:.::...:..:.:|.|
  Rat    49 RFHRFLDVNSHKVEKTIEGIYEKLTIHSDLSKAASWKRLTKEFLNVALPSTEKIKTDTHYSILSL 113

  Fly   125 LFRIADRPVQKIRLNREFMEQRRLSIINSMEEAERQAQIEEQAKLEAAKNTSETEVDWAALLSED 189
            |..::|.|     .|..::            |..|:.::|:           :.:.||...|.|.
  Rat   114 LLCLSDSP-----SNSNYV------------ETPREKEVEK-----------KDDFDWGKYLMEG 150

  Fly   190 ---FLDPPEDDSSDSLSDWSEESDCDST--TTLKPDENIGVSRSLLEMARVYEQAMMAVVPTGSV 249
               .|.|..|     ..:|||:||.:.|  ...:.|..|.|.|:.||
  Rat   151 EEVGLGPDMD-----TPNWSEDSDDEDTQQPLSREDSGIQVDRTPLE------------------ 192

  Fly   250 NKTYMPPEQSVIRSYDFRIMKPTVLSLNNLKGSHLRRSKLLQLPPPQPPRPFTQYWQSGNTDTLF 314
                   ||.                 :|.||.         |.......|.::.|...:.
  Rat   193 -------EQD-----------------HNRKGG---------LQVCWEDEPDSRSWLEQHV---- 220

  Fly   315 RKIHSHWWCQDVHLNALPSSAKPLDNFAVSYVQFLNHNARGLLALPVPK---TITEPCLLREILF 376
              :|.:|   ....:.:|.|:....|.|..:.|.|..:.    .|.||.   .:||..::||.|:
  Rat   221 --VHQYW---TTRRSRIPHSSHLHSNLAAVWDQHLYSSD----PLYVPDDRVVVTETQVIRETLW 276

  Fly   377 MF--VRPASCCFFEFDKATRRITVRDNVSICTVTASTMQNFLLFDVVPALEDMMELRHIIDTHTL 439
            :.  |:.    .|.|.....::|||||:.:..:|.|.::: :|..:....:.:..|:..||....
  Rat   277 LLSGVKK----LFIFQLIDGKVTVRDNIIVTHLTHSCLRS-VLEQIAAYGQVVFRLQEFIDEVMG 336

  Fly   440 HF-------HG--VKTTYTVEFFAYGLRDLVQPICQLLIAYEDRVNKDPAKNTLIRFTIEFREHF 495
            |.       :|  .|.|....|..|          |..:.            .|.::.|.|:|..
  Rat   337 HSSESPSPGNGPIPKKTPDAPFRTY----------QAFMW------------ALYKYFINFKEEL 379

  Fly   496 SQL------------------RLLRELAEDVILDK----GPAH--------IRSAYLLSRLYKHT 530
            :::                  :|...||:..:|||    |.|.        :|:::||:.||| .
  Rat   380 TEIEKSVISNDTTITLAIVVNKLAPRLAQLKVLDKVFSTGVAEVPPDTRNVVRASHLLNTLYK-A 443

  Fly   531 LLQVPH----QKLATALLFI----SLKRYCIIIDGWWRRAALEDHLREFIV-----------EFC 576
            :|:..:    .:...:|||.    :::.|...:|.|.....|.|..||||:           :|.
  Rat   444 ILEYDNVGEASEQTVSLLFSLWVETVRPYLQTVDEWIVHGHLWDGAREFIIQRNKNVPVNHRDFW 508

  Fly   577 Y----------------------------EEDANTRSH--------VRKRNMGMEDDLLLVEIFN 605
            |                            ::..::|.|        |.|:.:.....:.|::..|
  Rat   509 YATYTLYSVSEKTENEDKVSDSASASSGSDQGPSSRQHTMVSFLKPVLKQIIMAGKSMQLLKNLN 573

  Fly   606 KLQ--SC----------PLYQLLLEH---ALESGE------------TQDLLCSVNTLSEMLTSN 643
            ..:  :|          .||.|.||.   .|:.||            |::.|..:.:::|
  Rat   574 CAEGSACQAAARDAERKSLYTLFLESIQLRLQHGEDSTTHILNEEQATKENLIKMQSIAE----- 633

  Fly   644 NEIQLPSLHDELFTQFFAQLKVYCGADNTDYEDEPE-----PDKDYEDLTVCNRQGIRNHELFAI 703
            ..::|..:||.|....||:|.:    :.:|:.::..     .|:..|.:| |        :.|.:
  Rat   634 RHLELDDIHDPLLAINFARLYL----EQSDFHEKFAGGDICVDRSSESVT-C--------QTFEL 685

  Fly   704 FTQPLVEQRLERQRERLKSNPVLMANILKRLERSTCLQLKSELPEALREILRRRQWLANEYAIRA 768
            ..:..:...:::|...      ...|:::.|:|
  Rat   686 TLRSCLYPHIDKQYLH------CCGNLMQTLKR-------------------------------- 712

  Fly   769 YCKETQVAEKMRFLRHTMLLEKYYLFVPYYNALFVRMEKNNSWALGSVLTSKLCAVLLPHYPQLA 833
               :.::.|.::.:|:..|:|.......:|.::|.::.:..:|...|.|..:|...:...||:.:
  Rat   713 ---DFRLVEYLQAMRNFFLMEGGDTMYDFYTSIFDKIREKETWQNVSFLNVQLQEAVGQRYPEDS 774

  Fly   834 HYLHVKLISQINSNSIKV-YEALEAIELDFERPMAMHQW---YILTPAHMQDYNSVWRLMLKVKW 894
            ..|.:. ...:::...|: ...|:.:.|.::.|     |   .:::....:.||.|:.|:|::||
  Rat   775 LRLSIS-FENVDTTKKKLPVHILDGLTLSYKVP-----WPVDIVISVECQKIYNQVFLLLLQIKW 833

  Fly   895 AVWKLENMQF----------------LR----RARFNPCAPLDLIGLTIRRLEIVRFWLIFLINN 939
            |.:.|:.:.|                ||    .|:|.|  |.:.:...|.|:.::|..|:..:|:
  Rat   834 AKYSLDVLLFGELANAAEKSQAKEDVLRDQDTPAQFGP--PKESLRQQIHRMFLLRVKLMHFVNS 896

  Fly   940 LHAHIM----EAVSRQFELRIGECKNVRELRIMHDEHLAWLKTHCMLTDEFKAFRVALDQIFHLV 1000
            ||.:||    .:...:|:.::.|.|::.:|..:|..:|:.:...|:|.::....:.|:.::.:|.
  Rat   897 LHNYIMTRILHSTGLEFQHQVEEAKDLDQLIKIHYRYLSTIHDRCLLREKVSFVKEAIMKVLNLA 961

  Fly  1001 YVLDMEWTTCASCMHDHDALCLDVTISDDGIDDSETQRRSLEYLALNQVAEIELTYIRCHQMLAD 1065
            .:....|                              :..|....:..:.::|..:..||..|..
  Rat   962 LMFAEGW------------------------------QAGLGAWQMESIEKMESDFKNCHMFLVT 996

  Fly  1066 ILNTLVHQNDHGFLSALEETINSSVPH 1092
            |||..|              ...|.||
  Rat   997 ILNKAV--------------CRGSFPH 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip128	NP_573030.2	GCP5_NTD	25..130	CDD:439339	19/110 (17%)
		GCP_N_terminal	371..>574	CDD:465456	55/262 (21%)
		GCP_C_terminal	<873..1082	CDD:461187	45/232 (19%)
Tubgcp5	XP_063118388.1	None