Protein Alignment shtd and APC1

DIOPT Version :9

• Sequence 1: NP_573025.2
• Gene: shtd / 32473
• FlyBaseID: FBgn0004391
• Length: 2030
• Species: Drosophila melanogaster
• Sequence 2: NP_014227.4
• Gene: APC1 / 855549
• SGDID: S000005116
• Length: 1748
• Species: Saccharomyces cerevisiae
• Alignment Length: 1886
• Identity: 395/1886 - (20%)
• Similarity: 681/1886 - (36%)
• Gaps: 543/1886 - (28%)

  Fly   190 DDHLTAIC--VMDQDALRVY-CSNGEDFLANLDFPVSQLWQTKYGLLLEKDSSNALISHMSIPMP 251
            |...|..|  |:..|...|| ..||........|.:...:....|::||:::|.:.:.......|
Yeast    79 DFEKTPDCFVVVLSDIAHVYMLKNGGSTTVCFPFQIGNAFWYANGVILERETSASFMDGGYDLKP 143

  Fly   252 RLFSMSH-------PLHEACPVVL-----------KTATGSTGYMTEPEYTVVFTTEESDLVMLY 298
            ..|.:.|       |:   .|..|           .:|:|:...:.:....|:|.:::...:.::
Yeast   144 IEFDLKHKYITLTDPM---APFGLISITNTFKGGINSASGNKTDILQDFQLVLFPSDKDKCIAVF 205

  Fly   299 ---DAKFFKHFVARLRKVTPEEINYVSQQMELGQTLMGPRSMAGNSFSSTKQTGA-----TPKAT 355
               ::|..:.:.:|:..         |.|...|:.          :.||||:||.     :.|:.
Yeast   206 LDRNSKVLRFYYSRILS---------SDQSRKGEL----------TISSTKKTGLDAAGNSQKSG 251

  Fly   356 NLSFAARNINTTT---TGMGNQFGLSQSQSFSG----VLGQSNRASLGTPLSQLQSSISQQSMSV 413
            .:|...|..:..|   |.:.     |.|..|:.    :.|....||..|.:..|.||.|::|:|.
Yeast   252 GISKDLRKFSHLTRRSTSIN-----SNSHDFNAAERVLSGNVGNASGRTDIFALPSSCSRRSLSA 311

  Fly   414 KDMRKLTHVKPAKPIEPELCMEHIWTENIYGTQREFCEMATRAFIHTDL--VGQTFLCYLLARSC 476
            ...|...::.|.....|               ...|...:.....|:::  |.|..      :..
Yeast   312 TLDRMGNNIAPTNRAAP---------------SGFFDSSSANTATHSNITPVSQPM------QQQ 355

  Fly   477 RLQLVRLTGYGRGEVQLSTHASTLAAKDAVGLKRMHMIAVL----------DPSGSLLLYTGTVL 531
            :.:.:..|.....::.| |..|:|...|.:......:.::|          :....||::.....
Yeast   356 QQEYLNQTATSSKDIVL-TEISSLKLPDDIIFTSRRLSSILSKLKFLSLRFERREGLLIFHEPTH 419

  Fly   532 ISKVHITPFLAPT--SIPTPLVTPMTAAPSPSASPAPSHVKTPMAAAGPASGIPSGSSSFVEVRR 594
            ..|:.:...|...  |||..:.                                 |:|....:|.
Yeast   420 FCKIWLIDLLPDVLDSIPFKIY---------------------------------GNSPQNMIRL 451

  Fly   595 SSLLPTKAPGDVAA------FEEELHMLSPIQPQPVSYTQRQAHNVCKSLRDPAGNRLTLVYATG 653
            .: |..|.|..:.|      .|..|.::|..|       .::.:..|  |.||
Yeast   452 EN-LKLKEPSRIQAMYIHELLESCLILVSEGQ-------NKEEYKAC--LYDP------------ 494

  Fly   654 RMLRIALPFLNDTRLLTR---------------------CVATLRQVLSPTQFLDFVIRWYSDRN 697
             .::|..|..|.:..||:                     |...::.:.||...:.|:..|.|
Yeast   495 -FVKITSPSKNISEELTKQNSLPSLQKLFPYPETSFTKLCFEAVKYITSPAFNISFIFLWQS--- 555

  Fly   698 PPGSRNYSIEQEWLLFRSTLLALMGLTAAPDVDAGENYARCATPPLHTQFGGGATATESSDGSSC 762
                 .|||    ||.|:....:.||..  :.||..........|:.:.
Yeast   556 -----AYSI----LLSRANDDVVGGLKM--EHDAFSLVLSLLILPIPSS---------------- 593

  Fly   763 SSNSTLGGQDEPKKRRIY-NDCDDFTDDDWEFLLLQTTLAPCGADGHSYSVNIGALLFRMIPAIF 826
                  ..|:..:.:.|| .|.......|.|                        :...::|.|.
Yeast   594 ------SAQEYQEYKEIYERDLFQHLKQDSE------------------------ITSSVLPRIV 628

  Fly   827 FSLHLLYEDLKLDADFYGALPYLATFLHQLAIDM----QLESYVLHYILDFPELSNRTGKLSLLG 887
            ..|||:.|:..|:.........|..||......|    ..:||   |:   |::.:.: |..|..
Yeast   629 IGLHLIREEYSLNVLCRNEHALLGQFLRFATAAMGWPDLWQSY---YV---PKMDSES-KTFLHP 686

  Fly   888 AEHGAMMLHQELLRVPAPSVFAQLEHIIVGEEEVMP----YTFLECVNERSRILLQLVSLVTHGH 948
            .|..:...|.  |..| ||:...|..|.  |...:|    .:|...|...:::.|:    :|...
Yeast   687 REQNSTFFHP--LDEP-PSITKSLYSIT--ENSSIPLCPFISFSRLVATDTQVELR----ITPRS 742

  Fly   949 ERLNYWWQLLEIPGAVQANFTRRSKRNITADAPRSHQMLQLLLAMRLTRRDIERFPAAVHL---- 1009
            .::...::|:..|             |...|     .:|.:|.:.::.:.:::.:|..:.:
Yeast   743 FKILGLYELVHSP-------------NFLPD-----YVLGILSSFKVDKDELQTYPLGILVPLQN 789

  Fly  1010 ---IVAEALEEARLSPPMGCSMATYELILRPELAAHAQLPFLETSTGQPHCGRVYKEDSLSARCP 1071
               |:.:.|.|.|         ...||:.|.:|...:.:.....|..:....|..::..:..:.|
Yeast   790 ILKILEDKLSEVR---------DNLELLDRADLQRCSAIINSIRSDSKEVLKRGQRDSYMLCKVP 845

  Fly  1072 --PTGGSETDSPAQLR-------------------------RDDMDNMDTKLLRLR----FPDDM 1105
              ....|.:..|:.:.                         :||.|..:.:.|:|.    |.:|.
Yeast   846 LAKNRSSLSKKPSDIYSILSEIVKSASQVPLDGSAMRMSNIQDDEDIDEGRSLKLNAGLIFSEDK 910

  Fly  1106 RVDEVRRLLNSSEPVVIEVQQAPGTSDHEFIE-EQEKQLFA--LCSRTMTLPVGRGMFTLRTMLP 1167
            |...|..||....|...:.    .|:..|:.: ..:|:.||  :..||.|..||.|.....|..|
Yeast   911 RFTHVVSLLAYYRPTKTQF----FTTKTEYAQILAQKKYFAKIMALRTCTNGVGWGAVAYATEKP 971

  Fly  1168 RPSESLTMPKLCLLGKEPLKGTTIEMQQIEFPA-NMQMWPSFHNGVATGLKISPQAQDIDSNWIV 1231
            ..::...:..|.|:...| ..|.|.::..|..| ::..|..||.||::||:||.:|..|..:||.
Yeast   972 ISTQKWVIQPLNLISVFP-DDTKITVKAPEDIAHDIVEWGQFHAGVSSGLRISKKATGITGSWIA 1035

  Fly  1232 YNKPKTHSHNALE--HAGFLMALGLNGHLKTLSFMSVYKYLVKCDEMTNVGLLLGISAAHRGTMD 1294
            :||||     .|:  |.|||:.||||||||.|....:|.||...:...::|||||:|::.:|:||
Yeast  1036 FNKPK-----ELDAYHGGFLLGLGLNGHLKNLEEWHIYNYLSPRNTHISIGLLLGMSSSMKGSMD 1095

  Fly  1295 TKTTKLLSVHLEALLPATAMELDIPQSTQVAAIMGVGLLYQGSAKRHIAE------VLLQEIGRP 1353
            :|..|::||||.|.||:.:.:|:|....|.|.|:|:|:||..|..:.:::      |.|..:.
Yeast  1096 SKLIKVISVHLVAFLPSGSSDLNIDLKLQTAGIIGMGMLYLNSRHKRMSDSIFAQLVSLLNVN-- 1158

  Fly  1354 PGPEMENSIERESYAMTAGLSLGLVTLGQGE--------SPAGLRDLQLPDTLHYYMVGGVKRPI 1410
                 :..:..|.|.:.||:||||:.||.|:        |..||.| .||:.:  |....|:
Yeast  1159 -----DEMVADEEYRLAAGISLGLINLGAGQTKLRKWDSSLLGLGD-DLPEDV--YDSSDVE--- 1212

  Fly  1411 GGSQKEKYRLASFQVREGDTVNIDV--------TAPGATLALGLMFFNSGNAAIAEWMQPPDSRY 1467
               |...|...:.::.|..|...||        :..||.:|:..:|..|.|..|:. |...|.:.
Yeast  1213 ---QNVMYEDLTTKLLEIVTSTYDVENDWIPENSQIGAVIAIMFLFLKSNNFGISN-MLKVDLKE 1273

  Fly  1468 LLDM---VRPDFLLLRTISRGLILWQDVRPDNAWFQAQFPRALRAHLKLPFYENEYAPEDYDVDY 1529
            :|..   .||:.|:.|..:..:|||:.:..|                 |.|...:.   |..|.:
Yeast  1274 ILKANINTRPELLMYREWASNMILWEFIGDD-----------------LSFIMKDV---DIGVKF 1318

  Fly  1530 EAISQAYCNI---MAGAAFCIGLKYAGTENLVAFATLRSVIKDFLRFPSRPMGECAGRTTVESCL 1591
            ..::.....|   |||....:|:::|.|.||.....|.|::..||     |:.:..|:..::..|
Yeast  1319 SELNTDLLPIYYTMAGRILAMGIRFASTGNLKIRNILLSLVDKFL-----PLYQYPGKQNLDFRL 1378

  Fly  1592 M---------VLLISISLVFAGSGNCEILRIIRFL------------------------------ 1617
            .         |:::|:|:|...||:.|:||.:::|
Yeast  1379 TISVINVLTNVIVVSLSMVMCASGDLEVLRRVKYLHEVASGPYSDLFQEIPSSKSDVSGVTQVTS 1443

  Fly  1618 -----------------------RSRVGPQYPHIT------------YGSHMAIHMSLGLLFLGA 1647
                                   ||..|......|            ||..::.:::||.||||:
Yeast  1444 NTNTPGNSDRERVDETAASLDDERSSNGSDISDPTAYLEDKKDIDDHYGKFISTNLALGFLFLGS 1508

  Fly  1648 GRFTI-SQTPESIAALVCAFFPKFPIHSNDNRYHLQALRHLYVLAVEPRLFLPRDIDT----NKL 1707
            |::.: :.|.||||.|..:..|.:     ...:.||.|:|.:.:|||||..:.:||.|    |.:
Yeast  1509 GQYALNTSTLESIAFLSMSVLPTY-----TTPHPLQELKHFWSMAVEPRCLVIKDISTGDAVNNV 1568

  Fly  1708 CLANISVLEVGATELRRLPIAPCILPVLSTLQQVVVDDENYWPV--------------------- 1751
            .:..:...:|...|:.|....||:||..|.::.:.|....|:|:
Yeast  1569 PIELVVEEDVEKEEVIREISTPCLLPDFSKIKSIRVKMHGYFPLEVNFTKDYSASDFFSGGTIIY 1633

  Fly  1752 -------CFERS---RNWDQLEKALEMSAP-------IDIKKRTGCLSHLEDPDRLKSMLAQTLT 1799
                   .||..   ||.:.:..||:..|.       :::|...|   :......::|:..|.||
Yeast  1634 IQRKSESVFENKASFRNVEDIHVALKRKAAESKNYSRLNLKNEQG---NTTSSQLVESLGIQDLT 1695

  Fly  1800 M 1800
            |
Yeast  1696 M 1696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shtd	NP_573025.2	ANAPC1	195..298	CDD:289618	22/123 (18%)
APC1	NP_014227.4	ANAPC1	88..>132	CDD:289618	10/43 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344849
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1858
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5090
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005152
OrthoInspector	1	1.000	-	-		oto99110
orthoMCL	1	0.900	-	-		OOG6_102115
Panther	1	1.100	-	-	LDO	PTHR12827
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R68
SonicParanoid	1	1.000	-	-		X3674
TreeFam	0	0.000	Not matched by this tool.
	10	9.810