DRSC/TRiP Functional Genomics Resources

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Protein Alignment shtd and anapc1

DIOPT Version :10

Sequence 1:NP_573025.2 Gene:shtd / 32473 FlyBaseID:FBgn0004391 Length:2030 Species:Drosophila melanogaster
Sequence 2:NP_001072866.1 Gene:anapc1 / 780327 XenbaseID:XB-GENE-5894738 Length:1948 Species:Xenopus tropicalis


Alignment Length:2124 Identity:713/2124 - (33%)
Similarity:1067/2124 - (50%) Gaps:312/2124 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MIAVAEPPLEFVPRGRQTSAEHPGPHDQPMARHQLPTTEHL-------LLQRLQNVNISSAGEDC 58
            |||..:.. ||||.||..|..||...:..:.:.| |.:|..       |:..|:.|.|...    
 Frog    11 MIAAGDLQ-EFVPLGRDHSKHHPNALNLQLRQLQ-PASELWSSDGAAGLVGSLREVTIHEK---- 69

  Fly    59 PSGGQESWTVRE-LYDDYEASEERAALRRKLTERTKRCGLQATSLPNRLLNPPLVRRVEPMCDYM 122
               .:|||.:|: :.|..|.:|                                           
 Frog    70 ---NKESWQLRKGVGDPGEDAE------------------------------------------- 88

  Fly   123 VNNEEELYVNRNTVVWTQGVNDDDDTDNGVYRRMCFTTDTPVRFACFLNRSFVRGRLAQLKAAVH 187
              .:|||||..|.|:|::|......|   ||:  .||.|:||..|.:.:.:....     |....
 Frog    89 --YDEELYVAGNVVIWSKGSKIQAST---VYK--AFTVDSPVVQALWCDFTIFND-----KNDNE 141

  Fly   188 PDDDHL-TAICVMDQDALRVYCSNGEDFLANLDFPVSQLWQTKYGLLLEKDSSNAL----ISHMS 247
            .|:..| ..:||:....:.|:.::|:|::|.|.|.|:.:|.||||||.|::|::.|    .|...
 Frog   142 TDEGKLEKCVCVLQSSCINVHNTDGKDYIAPLPFQVANVWPTKYGLLFERNSNSTLHEVPQSPPR 206

  Fly   248 IPMPRLFSMSHPLHEACPVVLKT----ATGSTGYMTEPEYTVVFTTEESDLVMLYDAKFFKHFVA 308
            .|:|.:|||.|||.|..|:|.::    .:....|:::|...:|||..:..:||.||.....|.|.
 Frog   207 EPLPTIFSMLHPLDEITPLVSRSGGIFGSSRVHYVSDPTLRIVFTHSDPSIVMTYDTVQGSHTVW 271

  Fly   309 RLRKVTPEEINYVSQQMELGQTLMGPRSMAGNSFSSTKQTGATPKA------TNLSFAARNINTT 367
            .||||..||.|.|....::|....|..:.:..:...:...|.:|.|      ::|...:|::::.
 Frog   272 ALRKVKAEEQNAVLNLEQIGTPQHGMTTSSLTAHLRSVSKGESPTASPFQNFSSLHSQSRSVSSP 336

  Fly   368 -------TTGMGNQFGLSQS-------QSFSGVLGQSNRASLGTP------LSQLQSSISQQSMS 412
                   :..:.|...||:|       .||:||  |....|..||      .|...:|.|...:|
 Frog   337 SIHSRSHSPSISNMAALSRSHSPALGVHSFAGV--QRFNFSSNTPSPKRLGASGSPNSTSSDFLS 399

  Fly   413 VKDMRKLTHVKPAKPIEPELCMEHIWTENIYGTQREFCEMATRAFIHTDLVGQTFLCYLLARSCR 477
            |:          .:||.||||::|:|||.: ...||....||:.||.|||.||.|||:||....:
 Frog   400 VE----------TEPIVPELCLDHLWTETV-ANIREKNSQATKVFITTDLCGQKFLCFLLESFHQ 453

  Fly   478 LQLVRLTGYGRGEVQLSTHASTLAAKDAVGLKRMHMIAVLDPSGSLLLYTGTVLISKVHITPFLA 542
            |:||:..........:....:.::||||..::.:..:.||:.:|:|:||||.|.:.|:.|....|
 Frog   454 LRLVKFEESNDKSQLIFGSVTNISAKDAAPVEAIDTMVVLENNGNLVLYTGVVRVGKIFIQGLAA 518

  Fly   543 PT---SIPTPL-VTPMTAAPSPSASPAPSHVKTPMAAAGPASGIPSGSSSFVEVRRSSLLPTKAP 603
            |:   |.|.|. .||:.:..:| |.|...|: .||..||..|.:|       |:|.|:.|.....
 Frog   519 PSLGMSNPMPRPSTPLESISTP-AKPLNKHL-APMDEAGMLSPVP-------ELRDSTRLHESTY 574

  Fly   604 GDVAAFEEELHMLSPIQPQPVSYTQRQAHNVCKSLRDPAGNRLTLVYATGRMLRIALPFLNDTRL 668
            .|...|                   .|......|:|||..|||||....|.|:||::|.:..:.|
 Frog   575 LDDCTF-------------------HQFGTYIHSVRDPVHNRLTLEINNGSMVRISIPDIATSEL 620

  Fly   669 LTRCVATLRQVLSPTQFLDFVIRWYSDRNPPGS-RNYSIEQEWLLFRSTLLALMGLTAAPDVDAG 732
            :.:|:..::.:|.....:..:::||:..|.||. .|:|   ||.:|.:.|:.:||.         
 Frog   621 VKKCLQAIKYILPKEIAVQMLVKWYNCHNAPGGPTNHS---EWNMFVTCLMNMMGY--------- 673

  Fly   733 ENYARCATPPLHTQFGGGATATESSDGSSCSSNSTLGGQDEPKKRRIYNDCDDFTDDDWEFLL-- 795
                               ...:.|...:|....:|.....|||.|   ..:..:|:|||:|:  
 Frog   674 -------------------NTDKLSWTRNCDFEGSLSPVIAPKKAR---PSETGSDEDWEYLINS 716

  Fly   796 ----------------LQTTLAPCGADG--HSYSVNIGALLFRMIPAIFFSLHLLYEDLKLDADF 842
                            |.:..|....|.  :..|::..||||...||||:.|||.||:|||:...
 Frog   717 DYHRNVETHILARALQLDSLDALVAKDDIQNVVSLDSSALLFSHAPAIFYVLHLTYEELKLNTLM 781

  Fly   843 YGALPYLATFLHQLAIDMQLESYVLHYILDFPELSNRTGKLSLLGAEHGAMMLHQELLRVPAPSV 907
            ...:..|...|.|||.|:.|::|:..|..|:|.|...|.:...:.......|.:........||:
 Frog   782 REGIQSLVMLLLQLARDLNLDTYMDFYFRDYPTLVKTTNQTCRIEPTQIGFMNYPSFFTAEPPSI 846

  Fly   908 FAQLEHIIVGEEEVMPYTFLECVNERSRILLQLVSLVTHGHERLNYWWQLLEIPGAVQANFTRRS 972
            :..|...:.| |:|.||.:|..:.|||::::...:|...|.|.     .:|..|.......|...
 Frog   847 YHWLSSRLKG-EKVTPYPYLPGICERSKLVVLSFALYILGDET-----AVLHEPRKYLCKITAGQ 905

  Fly   973 KRNITADAPR------------SHQMLQLLLAMRLTRRDIERFPAAVHLIVAEALEEARLSPPMG 1025
            ::....|..|            |.:::..:..:..|.:|:|..|..|.|.:..|:.:.|..|...
 Frog   906 RKQQLGDDRRYSLKPTPSVSGLSEKLVVWMTNIGFTLQDLESLPFGVALPIRHAIYQCRQQPASD 970

  Fly  1026 CSMATYELILRPELAAHA---QLPFLETSTGQPHCGRVYKEDSLSARCPPTGGSETDSPAQLRRD 1087
            .:.....||.|.:|:..|   .||     ..:|..|.|     .|...||...:|.:.      |
 Frog   971 WAQGVCILIGRQDLSKQACDGNLP-----KAKPSAGPV-----PSPEVPPAADAEEED------D 1019

  Fly  1088 DMDNMDTKLLRLRFPDDMRVDEVRRLLNSSEPVVIEVQQAPGTSDHEFIEEQEKQLFALCSRTMT 1152
            .|::::.:::.|.:.:|:||.||||||.||.||.:.|.|.|..||||||||:|.:|..|..|||.
 Frog  1020 GMNDLNQEVMSLIWSEDLRVQEVRRLLQSSHPVRVNVVQMPEVSDHEFIEEKENRLLQLSQRTMA 1084

  Fly  1153 LPVGRGMFTLRTMLPRPSESLTMPKLCLLGKEPLKGTTIEMQ--QIEFPANMQMWPSFHNGVATG 1215
            ||||||||||.:..|.|:|.|.:|||.|.|:.|.:.||:::.  .|:.|.||..|.:||||||.|
 Frog  1085 LPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMACWANFHNGVAAG 1149

  Fly  1216 LKISPQAQDIDSNWIVYNKPKTHSHNALEHAGFLMALGLNGHLKTLSFMSVYKYLVKCDEMTNVG 1280
            |||:|.:| |||.|||||||| ::..|.|:|||||||||||||..|:.::::.||.|..|||::|
 Frog  1150 LKIAPASQ-IDSAWIVYNKPK-NAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIG 1212

  Fly  1281 LLLGISAAHRGTMDTKTTKLLSVHLEALLPATAMELDIPQSTQVAAIMGVGLLYQGSAKRHIAEV 1345
            ||||:|||..||||...|:|||:|:.||||.|:.|||:|.:.||||::|:||:|||:|.||||||
 Frog  1213 LLLGVSAAKLGTMDISITRLLSIHIPALLPPTSTELDVPHNVQVAAVIGIGLVYQGTAHRHIAEV 1277

  Fly  1346 LLQEIGRPPGPEMENSIERESYAMTAGLSLGLVTLGQGESPAGLRDLQLPDTLHYYMVGGVKRPI 1410
            ||.|||||||||||...:||||::.|||:||:|.||.|.:..|:.||.:|:.|:.|||||.||..
 Frog  1278 LLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVGGHKRSH 1342

  Fly  1411 GGSQKEKYRLASFQVREGDTVNIDVTAPGATLALGLMFFNSGNAAIAEWMQPPDSRYLLDMVRPD 1475
            .|..:||::..|:|::||||:|:|||.|||||||.:::..:.|.:||:|::.||:.||||.|:|:
 Frog  1343 VGVSREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPE 1407

  Fly  1476 FLLLRTISRGLILWQDVRPDNAWFQAQFPRALRAH-LKLPFYENEYAPEDYDVDYEAISQAYCNI 1539
            ||||||::|.||||.|:.|:..|..:..|:.:..: :.|...|.   |...|::.|.::||:..|
 Frog  1408 FLLLRTLARCLILWDDILPNAQWVNSNVPQIITDNSISLNATEQ---PSSEDLNLETLAQAHVYI 1469

  Fly  1540 MAGAAFCIGLKYAGTENLVAFATLRSVIKDFLRFPSRPMGECAGRTTVESCLMVLLISISLVFAG 1604
            :|||...:|.::|||.||.||..|....|||....::..| ..|...:|:||.|:|:|:|:|.||
 Frog  1470 IAGACLALGFRFAGTANLSAFNCLCKFAKDFECLSAQAAG-ITGHYNLETCLSVVLLSLSMVMAG 1533

  Fly  1605 SGNCEILRIIRFLRSRVGPQYPHITYGSHMAIHMSLGLLFLGAGRFTISQTPESIAALVCAFFPK 1669
            |||.::|::.||:..:.|.:   :.||.|:|.||:|||||||.||:::|.:..|||||:||.:|.
 Frog  1534 SGNLKVLQLCRFMHKKTGGE---MNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPH 1595

  Fly  1670 FPIHSNDNRYHLQALRHLYVLAVEPRLFLPRDIDTNKLCLANISVLEVGA---TELRRLPIAPCI 1731
            ||:||.||||||||||||||||.||||.:|.|:|||..|...:.|...|.   .|.....:||.:
 Frog  1596 FPVHSTDNRYHLQALRHLYVLASEPRLLVPVDVDTNLPCYVLLEVTYKGTQWYEETTEELMAPTL 1660

  Fly  1732 LPVLSTLQQVVVDDENYWPVCFERSRNWDQLEKALEMSAPIDIKKRTGCLSHLEDPDRLKSMLAQ 1796
            ||....|:|:.|....||.:..:..:..:.|:..|.....:.:|.|.|.||:.|||...:|:|||
 Frog  1661 LPEFHLLRQIKVKGPRYWEIVIDLRKGTEHLKSILSKDGVLYVKLRAGQLSYKEDPMGWRSLLAQ 1725

  Fly  1797 TLTMEQSICWQIDMNDLQQFASERMVKQFLSR-CLDTKGTDLSPPELMKRHQVMLLF----YNAV 1856
            .:|...|.........:..|.|:..:..|... |..|  ||:.     ::..::.||    |..|
 Frog  1726 AVTRRNSEVLTFKPEAISAFTSDPALLSFADYFCKST--TDMG-----QKQDILDLFSSILYECV 1783

  Fly  1857 VKDRMHFLPVYLTLYDHV----TKSMPNNIDVWQMKLIDAYLSRSQESEHPLISVELIQMMQELF 1917
            .::....||.|:.:...|    .:......::||:||:..:.|.:.              :||..
 Frog  1784 TQENPEMLPAYIAIDQAVRRLERRETTETFELWQIKLVLEFFSSAG--------------LQERM 1834

  Fly  1918 KQEMEDSTREL-----CLPLREFLSRRRLDP-----------SYVTTVSGPDLQRAF--CVINYY 1964
            |   ::|.|.|     .||:.:......||.           ||:...:..|.|.:.  |.:.|:
 Frog  1835 K---KNSNRGLFMNSEFLPIMKCTIDNTLDQWLQANGDVALHSYLAAQAVEDSQLSMLACFLVYH 1896

  Fly  1965 NL-LPNMLNGVDLSTGTVNYMRLLYEFRRLNLGAHTIFGLMKIL 2007
            :: .|..|:...|. |:.::..||.:|:.|.:....:..|..||
 Frog  1897 SVPEPKQLSEGGLQ-GSESFSELLLKFKDLKMPVRALLRLAPIL 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shtdNP_573025.2 Apc1_MidN 666..1040 CDD:466667 95/406 (23%)
anapc1NP_001072866.1 Apc1_N 1..133 CDD:437353 44/180 (24%)
ANAPC1 152..>281 CDD:463732 47/128 (37%)
Apc1_MidN 618..986 CDD:466667 96/407 (24%)
APC1_C 1743..1899 CDD:465659 36/179 (20%)

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