DRSC/TRiP Functional Genomics Resources

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Protein Alignment shtd and ANAPC1

DIOPT Version :10

Sequence 1:NP_573025.2 Gene:shtd / 32473 FlyBaseID:FBgn0004391 Length:2030 Species:Drosophila melanogaster
Sequence 2:XP_011509935.1 Gene:ANAPC1 / 64682 HGNCID:19988 Length:1948 Species:Homo sapiens


Alignment Length:2111 Identity:716/2111 - (33%)
Similarity:1096/2111 - (51%) Gaps:286/2111 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MIAVAEPPLEFVPRGRQTSAEHPGPHDQPMARHQLPTTEHLLLQRLQNVN--ISSAGEDCPSGGQ 63
            ||| |....||||.||.....|             |...:|.|::||..:  .||.|.....|..
Human    11 MIA-ARDLQEFVPFGRDHCKHH-------------PNALNLQLRQLQPASELWSSDGAAGLVGSL 61

  Fly    64 ESWTVRELYDDYEASEERAALRRKLTERTKRCGLQATSLPNRLLNPPLVRRVEPMCDYMVNNEEE 128
            :..|:      :|..:|...||:.::|                        :....||    :||
Human    62 QEVTI------HEKQKESWQLRKGVSE------------------------IGEDVDY----DEE 92

  Fly   129 LYVNRNTVVWTQGVNDDDDTDNGVYRRMCFTTDTPVRFACFLNRSFVRGRLAQLKAAVHPDDDHL 193
            |||..|.|:|::|   .......||:  .||.|:||:.|.:.:  |:..:....||  :..::..
Human    93 LYVAGNMVIWSKG---SKSQALAVYK--AFTVDSPVQQALWCD--FIISQDKSEKA--YSSNEVE 148

  Fly   194 TAICVMDQDALRVYCSNGEDFLANLDFPVSQLWQTKYGLLLEKDSSNALISHMS--IPMPRLFSM 256
            ..||::....:.::...|:|::|:|.|.|:.:|.||||||.|:.:|:..:...|  .|:|.:|||
Human   149 KCICILQSSCINMHSIEGKDYIASLPFQVANVWPTKYGLLFERSASSHEVPPGSPREPLPTMFSM 213

  Fly   257 SHPLHEACPVVLKTAT--GST--GYMTEPEYTVVFTTEESDLVMLYDAKFFKHFVARLRKVTPEE 317
            .|||.|..|:|.|:.:  ||:  .|:.:....:||...:..:||.|||....|.|..||:|..||
Human   214 LHPLDEITPLVCKSGSLFGSSRVQYVVDHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKSEE 278

  Fly   318 INYVSQQMELGQTLMGPRSMAGNS---------------FSSTKQTGATPKATNLSFAARNINTT 367
            .|.|.:..|.|.|   |:::|.:|               .:|..|..::..:.:.|.::.::::.
Human   279 ENVVLKFSEQGGT---PQNVATSSSLTAHLRSLSKGDSPVTSPFQNYSSIHSQSRSTSSPSLHSR 340

  Fly   368 TTGMGNQFGLSQS-------QSFSGV----LGQSNRASLGTPLSQLQSSISQQSMSVKDMRKLTH 421
            :..:.|...||::       .|||||    :...|::.....:|...:|.|..|....:      
Human   341 SPSISNMAALSRAHSPALGVHSFSGVQRFNISSHNQSPKRHSISHSPNSNSNGSFLAPE------ 399

  Fly   422 VKPAKPIEPELCMEHIWTENIYGTQREFCEMATRAFIHTDLVGQTFLCYLLARSCRLQLVRLTGY 486
               .:||.||||::|:|||.|... ||....|::.||.:||.||.|||:|:....:|:.|:....
Human   400 ---TEPIVPELCIDHLWTETITNI-REKNSQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQES 460

  Fly   487 GRGEVQLSTHASTLAAKDAVGLKRMHMIAVLDPSGSLLLYTGTVLISKVHITPFLAPTSIPTPLV 551
            ......:....:.:.||||..::::..:.||:.||:|:||||.|.:.||.|      ..:|.|.:
Human   461 NDKTQLIFGSVTNIPAKDAAPVEKIDTMLVLEGSGNLVLYTGVVRVGKVFI------PGLPAPSL 519

  Fly   552 TPMTAAPSPSASPAPSHVKTPMAAAGPASGIPSGSSSFV------EVRRSSLLPTKAPGDVAAFE 610
            |.....|.|| :|... |.||.    |.|.:.......|      |:|.||.|......:...|:
Human   520 TMSNTMPRPS-TPLDG-VSTPK----PLSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQ 578

  Fly   611 EELHMLSPIQPQPVSYTQRQAHNVCKSLRDPAGNRLTLVYATGRMLRIALPFLNDTRLLTRCVAT 675
                               |......|:|||..||:||..:.|.|:||.:|.:..:.|:..|:..
Human   579 -------------------QLGTYIHSIRDPVHNRVTLELSNGSMVRITIPEIATSELVQTCLQA 624

  Fly   676 LRQVLSPTQFLDFVIRWYSDRNPPGSRNYSIEQEWLLFRSTLLALMGLTAAPDVDAGENYARCAT 740
            ::.:|.....:..:::||:..:.||..:|  ..||.||.:.|:.:||.          |..|.|.
Human   625 IKFILPKEIAVQMLVKWYNVHSAPGGPSY--HSEWNLFVTCLMNMMGY----------NTDRLAW 677

  Fly   741 PPLHTQFGGGATATESSDGSSCSSNSTLGGQDEPKKRRIYNDCDDFTDDDWEFLL---------- 795
                       |.....:||       |.....|||.|   ..:..:|||||:||          
Human   678 -----------TRNFDFEGS-------LSPVIAPKKAR---PSETGSDDDWEYLLNSDYHQNVES 721

  Fly   796 ----LQTTLAPCGAD-------GHSYSVNIGALLFRMIPAIFFSLHLLYEDLKLDADFYGALPYL 849
                ....|:|..|.       ..:.|::...|||..||||||.|||:||:|||:......:..|
Human   722 HLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMGEGICSL 786

  Fly   850 ATFLHQLAIDMQLESYVLHYILDFPELSNRTGKLSLLGAEHGAMMLHQELLRVPAPSVFAQLEHI 914
            ...|.|||.|::|..||.||..|:|.|...||::..:.......|.|........||::..:...
Human   787 VELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSC 851

  Fly   915 IVGEEEVMPYTFLECVNERSRILLQLVSLVTHGHERL------NYWWQLLEIPGAVQA--NFTRR 971
            :.| |.:.||.:|..:.||||:::..::|...|.|.|      .|..::...|..:|.  ...|.
Human   852 LKG-EGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRITIAPQKLQVEQEENRF 915

  Fly   972 SKRNITADAPRSHQMLQLLLAMRLTRRDIERFPAAVHLIVAEALEEARLSPPMGCSMATYELILR 1036
            |.|:.|:.:..:.:::..:..:..|.||:|..|..:.|.:.:|:...|..|......|...||.|
Human   916 SFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGR 980

  Fly  1037 PEL---AAHAQLPFLETSTGQPHCGRVYKEDSLSARCPPTGGSETDSPAQLRRDDMDNMDTKLLR 1098
            .:|   |....||..::|..|          .||:..|  .|:||:.    ..|.|::|:.:::.
Human   981 QDLSKQACEGNLPKGKSSVTQ----------VLSSDVP--SGTETEE----EDDGMNDMNHEVMS 1029

  Fly  1099 LRFPDDMRVDEVRRLLNSSEPVVIEVQQAPGTSDHEFIEEQEKQLFALCSRTMTLPVGRGMFTLR 1163
            |.:.:|:||.:|||||.|:.||.:.|.|.|..||||||||:|.:|..||.|||.||||||||||.
Human  1030 LIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHEFIEEKENRLLQLCQRTMALPVGRGMFTLF 1094

  Fly  1164 TMLPRPSESLTMPKLCLLGKEPLKGTTIEMQ--QIEFPANMQMWPSFHNGVATGLKISPQAQDID 1226
            :..|.|:|.|.:|||.|.|:.|.:.||:::.  .|:.|.||..|.|||||||.||||:|.:| ||
Human  1095 SYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNGVAAGLKIAPASQ-ID 1158

  Fly  1227 SNWIVYNKPKTHSHNALEHAGFLMALGLNGHLKTLSFMSVYKYLVKCDEMTNVGLLLGISAAHRG 1291
            |.|||||||| |:..|.|:|||||||||||||..|:.::::.||.|..|||::|||||:|||..|
Human  1159 SAWIVYNKPK-HAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLG 1222

  Fly  1292 TMDTKTTKLLSVHLEALLPATAMELDIPQSTQVAAIMGVGLLYQGSAKRHIAEVLLQEIGRPPGP 1356
            |||...|:|||:|:.||||.|:.|||:|.:.||||::|:||:|||:|.||.|||||.||||||||
Human  1223 TMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLVYQGTAHRHTAEVLLAEIGRPPGP 1287

  Fly  1357 EMENSIERESYAMTAGLSLGLVTLGQGESPAGLRDLQLPDTLHYYMVGGVKRPIGGSQKEKYRLA 1421
            |||...:||||::.|||:||:|.||.|.:..|:.||.:|:.|:.|||||.:|...|..:||::..
Human  1288 EMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVGGHRRFQTGMHREKHKSP 1352

  Fly  1422 SFQVREGDTVNIDVTAPGATLALGLMFFNSGNAAIAEWMQPPDSRYLLDMVRPDFLLLRTISRGL 1486
            |:|::||||:|:|||.|||||||.:::..:.|.:||:|::.||:.||||.|:|:||||||::|.|
Human  1353 SYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTLARCL 1417

  Fly  1487 ILWQDVRPDNAWFQAQFPRALR------AHLKLPFYENEYAPEDYDVDYEAISQAYCNIMAGAAF 1545
            |||.|:.|::.|..:..|:.:|      :.::||..|        |::.|.:|||:..|:|||..
Human  1418 ILWDDILPNSKWVDSNVPQIIRENSISLSEIELPCSE--------DLNLETLSQAHVYIIAGACL 1474

  Fly  1546 CIGLKYAGTENLVAFATLRSVIKDFLRFPSRPMGECAGRTTVESCLMVLLISISLVFAGSGNCEI 1610
            .:|.::||:|||.||..|....|||:.:.|.|.....|...:|:||.|:|:|:::|.|||||.::
Human  1475 SLGFRFAGSENLSAFNCLHKFAKDFMTYLSAPNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKV 1539

  Fly  1611 LRIIRFLRSRVGPQYPHITYGSHMAIHMSLGLLFLGAGRFTISQTPESIAALVCAFFPKFPIHSN 1675
            |::.|||..:.|.:   :.||.|:|.||:|||||||.||:::|.:..|||||:||.:|.||.||.
Human  1540 LQLCRFLHMKTGGE---MNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHST 1601

  Fly  1676 DNRYHLQALRHLYVLAVEPRLFLPRDIDTNKLCLANISVLEVGA---TELRRLPIAPCILPVLST 1737
            ||||||||||||||||.||||.:|.|:|||..|.|.:.|...|.   .:.:...:||.:||.|..
Human  1602 DNRYHLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHL 1666

  Fly  1738 LQQVVVDDENYWPVCFERSRNWDQLEKALEMSAPIDIKKRTGCLSHLEDPDRLKSMLAQTLTMEQ 1802
            |:|:.|....||.:..:.|:....|:..|.....:.:|.|.|.||:.|||...:|:||||:....
Human  1667 LKQIKVKGPRYWELLIDLSKGTQHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRN 1731

  Fly  1803 SICWQIDMNDLQQFASERMVKQFLSR-CLDTKGTDLSPPELMKRHQVMLLF----YNAVVKDRMH 1862
            |.........:..|.|:..:..|... |..|       ..:.::.:::.||    |..|.::...
Human  1732 SEARAFKPETISAFTSDPALLSFAEYFCKPT-------VNMGQKQEILDLFSSVLYECVTQETPE 1789

  Fly  1863 FLPVYLTLYDHV----TKSMPNNIDVWQMKLI-DAYLSRSQE---SEHP----LISVELIQMMQE 1915
            .||.|:.:...:    .:.|....::||:||: :.:.|||.:   ..||    .::.|.:.:::.
Human  1790 MLPAYIAMDQAIRRLGRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKC 1854

  Fly  1916 LFKQEMEDSTR---ELCLPLREFLSRRRLDPSYVTTVSGPDLQRAFCVINYYNL-LPNMLNGVDL 1976
            .....::...:   ::|  :..:||.:.|:.|.::.::        |.:.|::: .|..|..:.|
Human  1855 TIDNTLDQWLQVGGDMC--VHAYLSGQPLEESQLSMLA--------CFLVYHSVPAPQHLPPIGL 1909

  Fly  1977 STGTVNYMRLLYEFRRLNLGAHTIFGLMKIL 2007
            . |:.::..||::|::|.:....:..|..:|
Human  1910 E-GSTSFAELLFKFKQLKMPVRALLRLAPLL 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shtdNP_573025.2 Apc1_MidN 666..1040 CDD:466667 108/405 (27%)
ANAPC1XP_011509935.1 Apc1_N 1..136 CDD:437353 46/179 (26%)
ANAPC1 151..359 CDD:463732 61/210 (29%)
Apc1_MidN 615..985 CDD:466667 108/403 (27%)
PC_rep 1471..1505 CDD:460361 14/33 (42%)
APC1_C 1743..1899 CDD:465659 30/172 (17%)

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