DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shtd and Anapc1

DIOPT Version :9

Sequence 1:	NP_573025.2	Gene:	shtd / 32473	FlyBaseID:	FBgn0004391	Length:	2030	Species:	Drosophila melanogaster
Sequence 2:	NP_001101241.1	Gene:	Anapc1 / 311412	RGDID:	1306629	Length:	1944	Species:	Rattus norvegicus

Alignment Length:	2119	Identity:	732/2119 - (34%)
Similarity:	1094/2119 - (51%)	Gaps:	306/2119 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIAVAEPPLEFVPRGRQTSAEHPGPHDQPMARHQLPTTEHLLLQRLQNVN--ISSAGEDCPSGGQ 63
            |||..:.. ||||.||.....|             |...:|.|::||..:  .||.|.....|..
  Rat    11 MIAAGDLQ-EFVPFGRDHCKHH-------------PNALNLQLRQLQPASELWSSDGAAGLVGSL 61

  Fly    64 ESWTVRELYDDYEASEERAALRRKLTERTKRCGLQATSLPNRLLNPPLVRRVEPMCDYMVNNEEE 128
            :..|:      :|..:|...||:.::|                        :....||    :||
  Rat    62 QEVTI------HEKQKESWQLRKGVSE------------------------IGDAADY----DEE 92

  Fly   129 LYVNRNTVVWTQGVNDDDDTDNGVYRRMCFTTDTPVRFACFLNRSFVRGRLAQLKA-AVHPDDDH 192
            |||..|.|:|::|   .......||:  .||.|:.|:.|.:.:  |:   ::|.|: .::...:.
  Rat    93 LYVAGNMVIWSKG---SKSQALAVYK--AFTVDSTVQQALWCD--FI---ISQDKSEKIYKSHEL 147

  Fly   193 LTAICVMDQDALRVYCSNGEDFLANLDFPVSQLWQTKYGLLLEKDSSNALI--SHMSIPMPRLFS 255
            ...||::....:.::..:|:|::|:|.|.|:.:|.||||||.|:.||:..:  |....|:|.:||
  Rat   148 EKCICILQSSCMNMHSIDGKDYIASLPFQVANVWATKYGLLFERSSSSHEVPPSLPREPLPTMFS 212

  Fly   256 MSHPLHEACPVVLKTAT--GST--GYMTEPEYTVVFTTEESDLVMLYDAKFFKHFVARLRKVTPE 316
            |.|||.|..|:|.|:.:  ||:  .|:.:|...:||...:..:||.|||....|.|..||:|.||
  Rat   213 MLHPLDEITPLVCKSGSLFGSSRVQYVVDPAVKIVFLNIDPSIVMTYDAVQNVHSVWTLRRVKPE 277

  Fly   317 EINYVSQQMELGQTLMGPRSMAGNSFSSTK-----QTGATPKAT-----------NLSFAARNIN 365
            |...|.:..|...||..    |..|.|.|.     ..|.:|.|:           :.|.::.:::
  Rat   278 EETAVLKFPEQAGTLQN----AATSSSLTAHLRSLSKGESPVASPFQNYSSIHSQSRSASSPSLH 338

  Fly   366 TTTTGMGNQFGLSQS-------QSFSGV----LGQSNRASLGTPLSQLQSSISQQ-SMSVKDMRK 418
            :.:..:.|...||::       .|||||    |...|:       |..:.|||.. |.|..|
  Rat   339 SRSPSISNMAALSRAHSPALGVHSFSGVQRFNLSSHNQ-------SPKRHSISHSPSGSFND--- 393

  Fly   419 LTHVKP-AKPIEPELCMEHIWTENIYGTQREFCEMATRAFIHTDLVGQTFLCYLLARSCRLQLVR 482
             :.:.| .:||.||||::|:|||.: ...||....|::.||.|||.||.|||:|:....:|:.|:
  Rat   394 -SFLAPETEPIVPELCIDHLWTETL-PNMREKNSQASKVFITTDLCGQKFLCFLVEAQLQLRCVK 456

  Fly   483 LTGYGRGEVQLSTHASTLAAKDAVGLKRMHMIAVLDPSGSLLLYTGTVLISKVHITPFLAPTSIP 547
            ..........:....:.:.||||..::::..:.||:.:|:|:||||.|.:.||.|      ..:|
  Rat   457 FQESNDKTQLIFGSVTNIHAKDAAPVEKIDTMLVLEGNGNLVLYTGVVRVGKVFI------PGLP 515

  Fly   548 TPLVTPMTAAPSPSASPAPSHVKTPMAAAGPASGIPSGSSSFV------EVRRSSLLPTKAPGDV 606
            .|.:|.....|.|| :|... |.||.    |.|.:.......|      |:|.||.|      :.
  Rat   516 APSLTMSNMMPRPS-TPLDG-VSTPK----PLSKLLGSMDEVVLLSPVPELRDSSKL------ND 568

  Fly   607 AAFEEELHMLSPIQPQPVSYTQRQAHNVCKSLRDPAGNRLTLVYATGRMLRIALPFLNDTRLLTR 671
            :.:.|:.             |.:|......|:|||..||:||..:.|.|:||.:|.:..:.|:..
  Rat   569 SLYNEDC-------------TFQQLGTYIHSVRDPVHNRVTLELSNGSMVRITIPEVATSELVQT 620

  Fly   672 CVATLRQVLSPTQFLDFVIRWYSDRNPPGSRNYSIEQEWLLFRSTLLALMGLTAAPDVDAGENYA 736
            |:..::.:|.....:..:::||:..:.||..  |...||.||...||.:||.          |..
  Rat   621 CLQAIKFILPKEVAVQVLVKWYNVHSAPGGP--SCHSEWSLFVICLLNMMGY----------NTD 673

  Fly   737 RCATPPLHTQFGGGATATESSDGSSCSSNSTLGGQDEPKKRRIYNDCDDFTDDDWEFLL------ 795
            |.|.             |.|.|     ...:|.....|||.|   ..|..:|||||:||
  Rat   674 RLAW-------------TRSFD-----FEGSLSPVIAPKKAR---PSDTGSDDDWEYLLNSEYHH 717

  Fly   796 ---------------LQTTLAPCGADGHSYSVNIGALLFRMIPAIFFSLHLLYEDLKLDADFYGA 845
                           |:.|.........:.|::...|||..||||||.|||:||:|||:......
  Rat   718 NVESHLLNKSLCLNALEVTKTKDEDFPQNLSLDSSTLLFAHIPAIFFVLHLVYEELKLNTLMGEG 782

  Fly   846 LPYLATFLHQLAIDMQLESYVLHYILDFPELSNRTGKLSLLGAEHGAMMLHQELLRVPAPSVFAQ 910
            :..|...|.|||.|::||.|:.||..|:|.|...||::..:.......|.|........||::..
  Rat   783 ICSLIDLLVQLARDLKLEPYLDHYYRDYPTLVKTTGQVCTIDQGQMGFMHHPSFFTSEPPSIYQW 847

  Fly   911 LEHIIVGEEEVMPYTFLECVNERSRILLQLVSLVTHGHERL------NYWWQLLEIPGAVQA--- 966
            :...:.| |...||.:|..:.||||:::..::|.|.|.|..      .|..::...|...||
  Rat   848 VSSCLKG-EGTPPYPYLPGICERSRLVVLSIALYTLGDESCVSDETSQYLSKVTLTPQKPQAEQE 911

  Fly   967 --NFTRRSKRNITADAPRSHQMLQLLLAMRLTRRDIERFPAAVHLIVAEALEEARLSPPMGCSMA 1029
              .||.|...:::..|.|   ::..:.::..|.||:|..|..:.|.:.:|:...|..|....|.|
  Rat   912 ENRFTFRQSASVSVLAER---LVVWMASVGFTLRDLETLPFGIALPIRDAIYHCREQPDSDWSEA 973

  Fly  1030 TYELILRPELAAHAQLPFLETSTGQPHCGRVYKEDSLSARCPPTGGSETDSPAQLRRDDMDNMDT 1094
            ...||.|.:|:..|      .....|....|...|..|       |:|    |:...|.|::::.
  Rat   974 VCLLIGRQDLSKQA------CEGNLPRGKSVLSSDVAS-------GAE----AEEEDDGMNDLNH 1021

  Fly  1095 KLLRLRFPDDMRVDEVRRLLNSSEPVVIEVQQAPGTSDHEFIEEQEKQLFALCSRTMTLPVGRGM 1159
            :::.|.:.:|:||.:|||||.|::||.:.|.|.|..||||||||:|.:|..||.|||.|||||||
  Rat  1022 EVMSLIWSEDLRVQDVRRLLQSAQPVRVNVVQYPELSDHEFIEEKENRLLQLCQRTMALPVGRGM 1086

  Fly  1160 FTLRTMLPRPSESLTMPKLCLLGKEPLKGTTIEMQ--QIEFPANMQMWPSFHNGVATGLKISPQA 1222
            |||.:..|.|:|.|.:|||.|.|:.|.:.||:::.  .|:.|.||..|.|||||||.||||:|.:
  Rat  1087 FTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMASWASFHNGVAAGLKIAPAS 1151

  Fly  1223 QDIDSNWIVYNKPKTHSHNALEHAGFLMALGLNGHLKTLSFMSVYKYLVKCDEMTNVGLLLGISA 1287
            | |||.|||||||| |:..|.|:|||||||||||||..|:.::::.||.|..|||::|||||:||
  Rat  1152 Q-IDSAWIVYNKPK-HAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSA 1214

  Fly  1288 AHRGTMDTKTTKLLSVHLEALLPATAMELDIPQSTQVAAIMGVGLLYQGSAKRHIAEVLLQEIGR 1352
            |..||||...|:|||:|:.||||.|:.|||:|.:.||||::|:||:|||:|.||.|||||.||||
  Rat  1215 AKLGTMDMSITRLLSIHVPALLPPTSTELDVPHNVQVAAVVGIGLVYQGTAHRHTAEVLLAEIGR 1279

  Fly  1353 PPGPEMENSIERESYAMTAGLSLGLVTLGQGESPAGLRDLQLPDTLHYYMVGGVKRPIGGSQKEK 1417
            |||||||...:||||::.|||:||:|.||.|.:..|:.||.:|:.|:.|||||.:|...|..:||
  Rat  1280 PPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVGGHRRFQTGMHREK 1344

  Fly  1418 YRLASFQVREGDTVNIDVTAPGATLALGLMFFNSGNAAIAEWMQPPDSRYLLDMVRPDFLLLRTI 1482
            ::..|:|::||||:|:|||.|||||||.:::..:.|.:||:|::.||:.||||.|:|:||||||:
  Rat  1345 HKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTL 1409

  Fly  1483 SRGLILWQDVRPDNAWFQAQFPRALR------AHLKLPFYENEYAPEDYDVDYEAISQAYCNIMA 1541
            :|.||||.|:.|::.|..:..|:.:|      :.::||..|        |::.|.:|||:..|:|
  Rat  1410 ARCLILWDDILPNSKWVDSNVPQIIRENSISLSEIELPCSE--------DLNLETLSQAHVYIIA 1466

  Fly  1542 GAAFCIGLKYAGTENLVAFATLRSVIKDFLRFPSRPMGECAGRTTVESCLMVLLISISLVFAGSG 1606
            ||...:|.::||:|||.||..|....|||:.:.|.|.....|...:|:||.|:|:|:::|.||||
  Rat  1467 GACLSLGFRFAGSENLSAFNCLHKFAKDFMNYLSAPNASVTGPYNLETCLSVVLLSLAMVMAGSG 1531

  Fly  1607 NCEILRIIRFLRSRVGPQYPHITYGSHMAIHMSLGLLFLGAGRFTISQTPESIAALVCAFFPKFP 1671
            |.::|::.|||..:.|.:   :.||.|:|.||:|||||||.||:::|.:..|||||:||.:|.||
  Rat  1532 NLKVLQLCRFLHMKTGGE---MNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFP 1593

  Fly  1672 IHSNDNRYHLQALRHLYVLAVEPRLFLPRDIDTNKLCLANISVLEVGA---TELRRLPIAPCILP 1733
            .||.||||||||||||||||.||||.:|.|:|||..|.|.|.|...|.   .:.:...:||.:||
  Rat  1594 AHSTDNRYHLQALRHLYVLAAEPRLLVPVDVDTNTPCYALIEVTYKGTQWYEQTKEELMAPTLLP 1658

  Fly  1734 VLSTLQQVVVDDENYWPVCFERSRNWDQLEKALEMSAPIDIKKRTGCLSHLEDPDRLKSMLAQTL 1798
            .|..|:|:.|....||.:..:.|:....|...|.....:.:|.|.|.||:.|||...:|:||||:
  Rat  1659 ELHLLKQMKVKGPRYWELLIDLSKGEQHLRSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTV 1723

  Fly  1799 TMEQSICWQIDMNDLQQFASERMVKQFLSR-CLDTKGTDLSPPELMKRHQVMLLF----YNAVVK 1858
            ....|.........:..|.|:..:..|... |..|       ..:.::.:::.||    |..|.:
  Rat  1724 ANRNSEARAFKPETISSFTSDPALLSFAEYFCKPT-------VSMGQKQEILDLFSSILYECVAQ 1781

  Fly  1859 DRMHFLPVYLTLYDHVTKS-----MPNNIDVWQMKLI-DAYLSRS---QESEHP----LISVELI 1910
            :....||.|:.: |...:|     |.|..|:||:||| :.:.|||   ::..:|    .|:.|.:
  Rat  1782 ETPEMLPAYIAM-DQALRSLKKRDMSNTSDLWQIKLILEFFSSRSHQERQQTYPKRGLFINSEFL 1845

  Fly  1911 QMMQELFKQEMEDSTRELCLP------LREFLSRRRLDPSYVTTVSGPDLQRAFCVINYYNL-LP 1968
            .:::...     |||.:..|.      :..:||.:.::.|.:..::        |.:.|::: .|
  Rat  1846 PVVKCTV-----DSTLDQWLQAGGDVCVHAYLSGQPVEKSQLNMLA--------CFLVYHSVPAP 1897

  Fly  1969 NMLNGVDLSTGTVNYMRLLYEFRRLNLGAHTIFGLMKIL 2007
            ..|..:.|. |:.::..||:.||.|.:....:..|..:|
  Rat  1898 RHLPPLGLE-GSTSFAELLFRFRHLKMPVRALLRLAPVL 1935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shtd	NP_573025.2	ANAPC1	195..298	CDD:289618	39/108 (36%)
Anapc1	NP_001101241.1	ANAPC1	150..>206	CDD:289618	19/55 (35%)
Anapc1	NP_001101241.1	PC_rep	1467..1501	CDD:280095	14/33 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346155
Domainoid	1	1.000	943	1.000	Domainoid score	I33
eggNOG	1	0.900	-	-		E1_KOG1858
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7414
Inparanoid	1	1.050	1018	1.000	Inparanoid score	I264
OMA	1	1.010	-	-		QHG46987
OrthoDB	1	1.010	-	-		D323458at33208
OrthoFinder	1	1.000	-	-		FOG0005152
OrthoInspector	1	1.000	-	-		oto95835
orthoMCL	1	0.900	-	-		OOG6_102115
Panther	1	1.100	-	-	LDO	PTHR12827
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3674
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770