Protein Alignment shtd and cut4

DIOPT Version :9

• Sequence 1: NP_573025.2
• Gene: shtd / 32473
• FlyBaseID: FBgn0004391
• Length: 2030
• Species: Drosophila melanogaster
• Sequence 2: NP_595158.1
• Gene: cut4 / 2539639
• PomBaseID: SPBC106.09
• Length: 1458
• Species: Schizosaccharomyces pombe
• Alignment Length: 1860
• Identity: 445/1860 - (23%)
• Similarity: 736/1860 - (39%)
• Gaps: 508/1860 - (27%)

  Fly   114 RVEPMCD---YMVNNEEELYVNRNTVVWTQGVNDDDDTDNGVYRRMCFTTDTPVRFACFLNRSFV 175
            |||.:.|   |:||:    ::||                  |:.   :|.|.....|..:. :|.
pombe    25 RVEIIGDAVHYIVND----HLNR------------------VFN---YTVDQQKIHAALIT-TFA 63

  Fly   176 RGRLAQLKAAVHPDDDHLTAICVMDQDALRVYC---SNGEDFLANLDFPVSQLWQTKYGLLLEKD 237
            .|:               .||.|:..|...||.   :|.:.::.|:.|.....|.:..||.|::.
pombe    64 SGK---------------KAIVVILDDIGYVYYVGDNNNDSYIINVPFSTESAWSSPSGLYLQRH 113

  Fly   238 SSNALISHMSIPMPRLFSMSHPLHEACPV------VLKTATGSTGYMTEPEYTVVFTTEESDLVM 296
            .|:.  .:::..:|.:|.::.||.|...:      :|....           ::|:...|  :|:
pombe   114 RSSD--ENLNTDLPHIFCLNDPLDELTLIKFDGKKILSLFD-----------SIVYVVGE--IVV 163

  Fly   297 LYDAKFFKHFVARLRKVTPEEINYVSQQMELGQTLMGPRS-MAGNSFSSTKQTGATPKATNLSFA 360
            .::.|..|....|.|.:.||.          .|::...|: ...:|||..|....| ::.::.:.
pombe   164 THNKKEKKLSFWRSRFIDPES----------DQSIKSSRNRRRESSFSREKNPDLT-RSDSIHYT 217

  Fly   361 ARNINTTTTGMGNQFGLSQSQSFSGVLGQSNRASLGTPLSQLQSSISQQSMSVKDMRKLTHVKPA 425
            |   ||..:....:.||:.|..||
pombe   218 A---NTRLSEKFEEQGLAYSTIFS----------------------------------------- 238

  Fly   426 KPIEPELCMEHIWTENIYGTQREFCEMATRAFIHTDLVGQTFLCYLLARSCRLQLVR-LTGYGRG 489
                      ||.:..|.|:......:.....:.|.||.:....|::.    .:||| .:.|...
pombe   239 ----------HIESFPITGSTSFDSILGNGVLVITTLVKELEKGYMML----FRLVRDRSPYFLD 289

  Fly   490 EVQLSTHASTLAAKDAVGLKRMHMIAVLDPSGSLLLYTGTVLISKVHITPFLAPTSIPTPLVTPM 554
            .:||  ||..|:   |:..|.:..|.||...|.:.|
pombe   290 SLQL--HAINLS---AIKSKHLQKIVVLSSKGKVSL----------------------------- 320

  Fly   555 TAAPSPSASPAPSHVKTPMAAAGPASGIPSGSSSFVEVRRSSLLPTKAPGDVAAFEEELHMLSPI 619
                           ::||:.:.|..|
pombe   321 ---------------ESPMSPSLPIEG-------------------------------------- 332

  Fly   620 QPQPVSYTQRQAHNVCKSLRDPAGNRLTLVYATGRMLRIALPFLNDTRLLTRCVATLRQVLSPTQ 684
                 ::...:.|.....|.|          ..|....|:|.......|:..|::.:|.||.
pombe   333 -----TFRSFRVHGATLYLED----------TDGVQRYISLDNRASNSLVKWCLSVIRYVLP--- 379

  Fly   685 FLDFVIRWYSDRNPPGSRNYSIEQEWLLFRSTLLALMGLTAAPDVDAGENYARCAT----PPLHT 745
                            .|.|.|     .:...|.||.....:.|.....:...|.|    ..:|.
pombe   380 ----------------LREYEI-----FYTGHLYALFAFKLSHDEAFISSILACFTFFSRDKVHV 423

  Fly   746 QFGGGATATESSDGSSCSSNSTLGGQDEPKKRRIYNDCDDFTDDDWEFLLLQTTLAPCGADGH-S 809
                                       ||     ..||::......:|...:..|.......| .
pombe   424 ---------------------------EP-----IEDCNEAYSLSSKFHFKKEILIASQLSSHLD 456

  Fly   810 YSVNIGALLFRMIPAIFFSLHLLYEDLKLDADFYGALPYLATFLHQLAIDMQLESYVLHYILDFP 874
            ||.....|:     .:..:||.:.|:|:||:........|...|.|:...::...|..:|..|..
pombe   457 YSTFKNYLM-----PLAITLHFISEELRLDSVVKPRKDQLVALLLQITTWLKWPRYCEYYNFDIA 516

  Fly   875 ELSNRTGKLSLLGAEHGAMMLHQELLRVPAPSVFAQLEHIIVGEEEVMPYTFLECVNERSRILLQ 939
            |                      ..|.:|. |:...:|. .||...::.: .:||:  ||:..:.
pombe   517 E----------------------TFLSIPL-SIQVDVEE-PVGPTSILQW-IIECL--RSQSTVP 554

  Fly   940 LVSLVTHGHERLNYWWQLLEIPGAVQANFTRRSKRNITADAPRSHQMLQLL-------------- 990
            ...|.::|            :|.:....|            |::..::|||
pombe   555 FYGLESYG------------LPHSCSTMF------------PQTLSLMQLLDCLLNPNMTLQNLV 595

  Fly   991 ---LAMRLTRRDIERFPAAVHLIVAEALEEA--RLSPPMGCSMATYELILRPELAAHAQLPFLET 1050
               :.:.::|:..||:|..:..|:...||.|  ..||    :..:.||.|...|...:   ||..
pombe   596 EEMVRLGISRKRCERYPFGILCIIFTVLEIAAEEYSP----NWESEELRLVNRLDVDS---FLHP 653

  Fly  1051 STGQPHCGRVY-KEDSLSARCPPTGGSETDSPAQLRRDDMDNMDTK-------LLRLRFPDDMRV 1107
            .|.:    .|: |:|...........:.|||..         :||:       :..:.|.:|.|:
pombe   654 KTPK----WVFNKQDQEVKEIKALTSTVTDSTL---------VDTQSFHPYKVVTDMIFREDRRL 705

  Fly  1108 DEVRRLLNSSEPVVIEVQQAPGTSDHEFIEEQEKQLFALCSRTMTLPVGRGMFTLRTMLPRPSES 1172
            .||.:|||.|..:.|..:..  ..|...:..|:|....:|.||:::|:|.||.|..:..|.|:|.
pombe   706 AEVNKLLNYSSQITIMTEHF--DVDLSSVPMQQKVAQCICVRTLSVPIGAGMLTYGSKNPLPTEK 768

  Fly  1173 LTMPKLCLLGKEPLKGTTIEMQQIEF-PANMQMWPSFHNGVATGLKISPQAQDIDSNWIVYNKPK 1236
            :| |:|.........||.|.....|| ...:..||.|:.|||.||.||..:::|:::||::|:|:
pombe   769 VT-PRLFNFTLHLHPGTLIIQPNKEFVTQELTEWPEFNVGVALGLSISKFSKEINTSWIMFNRPE 832

  Fly  1237 THSHNALEHAGFLMALGLNGHLKTLSFMSVYKYLVKCDEMTNVGLLLGISAAHRGTMDTKTTKLL 1301
            |.:   ..|||||..||||||||.|:....:.||....:.|::|||||:::::.|:||.|.||||
pombe   833 TLT---AYHAGFLFGLGLNGHLKALATWHSFIYLTSKHDTTSIGLLLGLASSYLGSMDAKVTKLL 894

  Fly  1302 SVHLEALLPATAMELDIPQSTQVAAIMGVGLLYQGSAKRHIAEVLLQEIGRPPGPEMENSIERES 1366
            |||:.||||..:.||:|...||.|.|:|:|||:..|..|.::||.::||......|::|    |.
pombe   895 SVHISALLPVGSNELNISPLTQTAGILGIGLLFHDSCHRRMSEVTMEEILASNESELKN----EG 955

  Fly  1367 YAMTAGLSLGLVTLGQGESPAGLRDLQLPDTLHYYMVGGVKRPIGGSQKEKYRLASFQVREGDTV 1431
            |.:.||.||||:.||:|.:..|:.||:|...|.          :|.|.:     |:||
pombe   956 YKLAAGFSLGLINLGRGSNLPGMSDLKLVSRLQ----------VGISSQ-----ATFQ------- 998

  Fly  1432 NIDVTAPGATLALGLMFFNSGNAAIAEWMQPPDSRYLLDMVRPDFLLLRTISRGLILWQDVRPDN 1496
            :::..:|||.:||.:::..:.:..:|:.:..|.||||||..|||.:|||...:.||:|.:|:.|.
pombe   999 SLEAGSPGAIMALTMIYMKTNDLEVAKKIDIPKSRYLLDFYRPDLILLRVAGKNLIMWDEVKADY 1063

  Fly  1497 AWFQAQFPRALRAHLKLPFYENEYAPEDYDVDYEAISQAYCNIMAGAAFCIGLKYAGTENLVAFA 1561
            .|.:.|.|..:.:...|  .|.:....|..:.|        |::||..|.:||::|||.|..|..
pombe  1064 EWVKYQIPDIMLSQFDL--QEKKVLSSDDLLLY--------NVLAGICFSLGLRFAGTGNPKAKE 1118

  Fly  1562 TLRSVIKDFLR---FPSRPMGECAGRTTVESCLMVLLISISLVFAGSGNCEILRIIRFLRSRVGP 1623
            .|.:.:..|:|   .|::...|.....||..|..::.:|.|.|.||..:.::||.:|.|..|:.|
pombe  1119 ILINFLDSFIRLCHLPAKTHDERVTAVTVIRCTQIVALSSSCVMAGYCDLDVLRRLRVLHGRMEP 1183

  Fly  1624 QYPHITYGSHMAIHMSLGLLFLGAGRFTISQTPESIAALVCAFFPKFPIHSNDNRYHLQALRHLY 1688
                :.||:.||.||:||:|.||.||:::|::..:||||:.:|:|:||..:.|||.||||.|:|:
pombe  1184 ----VNYGAQMATHMALGILSLGGGRYSLSRSNLAIAALLISFYPQFPRTTQDNRAHLQAARNLW 1244

  Fly  1689 VLAVEPRLFLPRDIDTNKLCLANISVLEVGATELRRLPIAPCILPVLSTLQQVVVDDENYWPVCF 1753
            .||||.|..:||:.||.:.|:..::|::.... :::|. ||.:||...::..|....:.||.:..
pombe  1245 ALAVEERCIIPRNQDTKQPCIVPLNVVQKSGA-VQKLE-APILLPPYDSISSVSTLGDKYWNLKI 1307

  Fly  1754 ERSRNWDQLEKALEMSA----PIDIKKRTGCLSHLEDPDRLKSMLAQTLTMEQSICWQIDMNDLQ 1814
            :...|.|..|...|...    |.|   ||   |..|:|..|...|..|    .|..|
pombe  1308 DLDNNSDYRELLRESQTLTLMPYD---RT---SSKEEPLNLFPKLKDT----SSPLW-------- 1354

  Fly  1815 QFASERMVKQFLSRCLDTKGTDLSPPELMKRHQ-----VMLLF---YNAVVKDRMHFLPVYLTLY 1871
                 .:||  .||...:..:.|:...|.:.:.     |.||.   ::.:.:||:..|.:.|..:
pombe  1355 -----NLVK--TSRLFQSSNSPLNVASLQESNNKTSLGVKLLLSMDFDNLTRDRLLSLQILLQFF 1412

  Fly  1872 DHVTKSMPNNIDVWQMKLIDAYLSRSQESEHPLISVELIQ 1911
            :          ..|...|::.:.||    ::..:|.:|::
pombe  1413 E----------SCWTGVLLNKFHSR----QYLFLSRDLVE 1438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shtd	NP_573025.2	ANAPC1	195..298	CDD:289618	23/111 (21%)
cut4	NP_595158.1	ANAPC1	68..>112	CDD:289618	13/43 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1858
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005152
OrthoInspector	1	1.000	-	-		oto100625
orthoMCL	1	0.900	-	-		OOG6_102115
Panther	1	1.100	-	-	LDO	PTHR12827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R68
SonicParanoid	1	1.000	-	-		X3674
TreeFam	1	0.960	-	-
	10	9.800