DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shtd and mat-2

DIOPT Version :9

Sequence 1:	NP_573025.2	Gene:	shtd / 32473	FlyBaseID:	FBgn0004391	Length:	2030	Species:	Drosophila melanogaster
Sequence 2:	NP_496383.2	Gene:	mat-2 / 174698	WormBaseID:	WBGene00003133	Length:	1505	Species:	Caenorhabditis elegans

Alignment Length:	1390	Identity:	325/1390 - (23%)
Similarity:	553/1390 - (39%)	Gaps:	313/1390 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   642 AGNRLTLVYATGRMLRIALPF------LNDTRLLTRCVATLRQVLSPTQFLDFVIRWYSDRNPPG 700
            |.||   ::|...|..|.:..      .:.|.|:..|...|.:.||    ...:|:|.|.:....
Worm   253 AENR---IFAVNEMRCIVVEIPETVTCKSATELMRTCFLHLDRDLS----RKLLIKWRSVKRDVD 310

  Fly   701 SRNYSIE-QEWLLFRSTLLALMGLTAAPDVDAGENYARCATPPLHTQFGGGATATESSDGSSCS- 763
            :....:: :|.:.....:|..:|:... :|.|.|   |..:|..|   ||.......||....|
Worm   311 TERLDLDRKEMIDVAIFMLDNVGVRVT-NVVAQE---RADSPEGH---GGKQMRPRMSDSEVLSM 368

  Fly   764 -----SNSTLGGQDEPKKRRIYNDCDDFTDDDWEFLLLQTTLAPCGADGHSYSVNIGALLFRMIP 823
                 ...|.    .||...|       |:|.:: ..|...|.|.| :|..::.:
Worm   369 MRQFFEEMTF----RPKSEVI-------TEDGYK-CHLSVELDPNG-EGFVHTQD---------- 410

  Fly   824 AIFFSLHLLYEDLKLDADFYGALPYLATFLHQLAIDMQLESYVLHYILDFPELSNRTGKLSLLGA 888
             :..:.|...||..::...:..|..|..:.:.||..|...::..:|:..|..|      ||.:..
Worm   411 -LLHAFHSQCEDWSINTMMHSILLELIPYAYLLAKVMNYRAFEEYYVQLFKHL------LSQIAI 468

  Fly   889 EHG-AMMLHQEL---LRVPAP--SVFAQLEHIIVGEEEVMPYTFLECVNERSRILLQLVSLVTHG 947
            |.. ...:|::.   :.:|.|  |:...:.|||.  |...|.|........|:..::|::::..|
Worm   469 EFKIPPEIHEKFVGAIHIPKPCWSLNNVIAHIIC--ERTTPETMESIPKFISKSSVRLLTILAVG 531

  Fly   948 HERLNY---------------WWQLLEIPGAVQANFTRRSKRNITADAPRSHQMLQLLLAMRLTR 997
            .:.:..               |.:.:.:.|.:..:|.|......:..|.|:.|:::|.....:|
Worm   532 RKFIGMGTNIDMDCERWLGKDWKRRIGLSGDILKSFRRIMNGKSSNSAGRASQLIELFEIGSIT- 595

  Fly   998 RDIERFPAAVHLIV----AEALEEARLSPPMGCSMATYELILRPELAAHAQLPFLETSTGQPHCG 1058
              |:....||.:::    .:|...|:...|..|..||
Worm   596 --IDFMVLAVKVLMLKFQTDAFAGAQSIEPKKCIYAT---------------------------- 630

  Fly  1059 RVYKEDSLSARCPPTGGSETDSPAQLRRDDMDNMDTKLLRLRFPDDMRVDEVRRLLNSSEPVVIE 1123
                                       .|:|    ..:..||:.:|:|:..|:.:||||.|::|.
Worm   631 ---------------------------ADEM----ISIAHLRWKNDIRMHNVQLMLNSSRPILIA 664

  Fly  1124 VQQAPGTSDHEFIEEQEKQLFALCSRTMTLPVGRGMFTLRTMLPRPSESLTMPKLCLLGKEPLKG 1188
            ........|....|.|::.|.....||.:.|.||.....||.:|....|:.:|:|.:.|......
Worm   665 TNILRKNEDDNMKELQDRFLTQTSYRTFSQPFGRAFLDFRTAVPSLLTSIYIPRLNVGGMIYPSR 729

  Fly  1189 TTIEMQQIEFPANMQMWPSFHNGVATGLKI-SPQAQDIDSNWIVYNKPKTHSHNALEHAGFLMAL 1252
            .|.:....|.......|.:|:|.:|:.|:| |.:...||:.|||.......|...:  .|..:..
Worm   730 VTCDPPTTEIFKLCTEWGNFYNSLASALRIGSSETVRIDNEWIVMVSKNIKSTAVI--GGMTLGF 792

  Fly  1253 GLNGHLKTLSFMSVYKYLVKCDEMTNVGLLLGISAAHRGTMDTKTTKLLSVHLEALLPATAMELD 1317
            ||||||...:....::.|...|:..:|.||:|:||::..|.|.:..|:|:.:|..|:..|.:|:.
Worm   793 GLNGHLAPFNMYHAHQMLSTFDKFHSVALLIGLSASNFTTCDVQIHKILATYLSFLMGPTPLEIK 857

  Fly  1318 IPQSTQVAAIMGVGLLYQGSAKRHIAEVLLQEIGRPPGPEMENSIERESYAMTAGLSLGLVTLGQ 1382
            :..:.|.|||.|:|||:..|....||:.|:.||||.|..:.|...:|.:|.::||.||||:.||:
Worm   858 LDFTIQTAAISGLGLLFADSGNMTIAKKLVNEIGRAPNRDEEPVTDRNAYKLSAGFSLGLIMLGK 922

  Fly  1383 GESPAGL-----RDLQLPDTLHYYMVGGVKR-----------PI----------GGSQKEKYRLA 1421
            |...|..     :::........||:.|::|           |:          .|......::|
Worm   923 GNGSASTVIPFKQNIPPMSQRLIYMMNGMRRDKCVFLPQVAPPVVNDVPNLPFSNGGMMTSSQVA 987

  Fly  1422 SFQVREGDTVNIDVTAPGATLALGLMFFNSGNAAIAEWMQPPDSRYLLDMVRPDFLLLRTISRGL 1486
            : .|:|.:.:||..:|..|.:|||:||....|..||..:..|.:...|:.::||.:..|.:::.|
Worm   988 N-HVKESEYINIHQSAEPAAIALGMMFMKMNNEFIANALALPGTITELERLKPDSMYSRVLAQCL 1051

  Fly  1487 ILWQDVRPDNAWFQAQFPRALR------AHLKLPFYENEYAPEDYD-------------VDYEAI 1532
            ::|..:.|.:.:.::..|..:|      .|..:|...:|...|.::             ||...:
Worm  1052 VMWDSIEPTHDFVKSLIPPVIREYATAALHFGVPIRRDEDGEEVHEAINDAEEKYWAEIVDKGTV 1116

  Fly  1533 SQAYCNIMAGAAFCIGLKYA-----GTENLV--AFATLRSVIKDFLRFP----SRPMGE---C-- 1581
            ||.:...::.|...|.||::     ..:|:|  ||..:....|  :..|    ::.||.   |
Worm  1117 SQTFLYAVSAACMAIALKFSSCGGPNEKNIVNTAFRIIEYYTK--IVMPDGKSNKDMGSIRMCIY 1179

  Fly  1582 AGRTTVESCLMVLLISISLVFAGSGNCEILRIIRFLRSRVGPQYPHITYG----SHMAIHMSLGL 1642
            :|..|..|||.:|:.:::::..|:|:.|::|..|.||....|:...|..|    ..|..|.:||:
Worm  1180 SGAYTRTSCLSMLITAMAILRVGTGDLEVMRYARLLRLCDKPESDWIATGKKHFEQMVAHQALGI 1244

  Fly  1643 LFLGAGRFTISQTPESIAALVCAFFPKFPIHSNDNRYHLQALRHLYVLAVEPRLFLPRDIDTNKL 1707
            |.||.||:...:...|||..:.:.||..|...:||.::.|.||.|:.:||||||.:|.||..:
Worm  1245 LMLGEGRYAFKKDDLSIALTIISTFPTIPQSVSDNSHYHQPLRFLWSMAVEPRLLVPFDIAES-- 1307

  Fly  1708 CLANISVLEVGATELRRLPI-----APCILPVLSTLQQVVVDDENYWPVCFERSRNWDQLEKALE 1767
            |:..:.|..|...:....||     ||.:||.|..||.:.:...||               :.:.
Worm  1308 CVVEVDVTIVMKPKDGNEPIVYKEKAPYLLPPLEDLQSISIGGGNY---------------QLVH 1357

  Fly  1768 MSAPIDIKKRTGCLSHLEDPDRLKSMLAQTLTMEQSICWQIDMNDLQQFASER-MVKQFLSRCLD 1831
            :|              |:..|::|.                 |.|:......| |:|::
Worm  1358 IS--------------LQSEDQVKV-----------------MKDIMTIGQGRVMLKRY------ 1385

  Fly  1832 TKGTDLSPPELMKRHQVMLLFYNAVVKDRMHFLPVYLTLYDHVTK--SMPNNIDV---------- 1884
              |.|.|.   ||            :|:.       .||||....  ||.||.|.
Worm  1386 --GVDSSE---MK------------IKEA-------TTLYDDTPSLMSMFNNEDTAVELDEYEIQ 1426

  Fly  1885 WQMKLIDAYLSRSQESEHPLISVEL 1909
            ..|:.||..::.:...|:|.:.:||
Worm  1427 CMMEKIDEGINLNSSDEYPNVQIEL 1451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
shtd	NP_573025.2	ANAPC1	195..298	CDD:289618
mat-2	NP_496383.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1858
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5090
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323458at33208
OrthoFinder	1	1.000	-	-		FOG0005152
OrthoInspector	1	1.000	-	-		oto18289
orthoMCL	1	0.900	-	-		OOG6_102115
Panther	1	1.100	-	-	LDO	PTHR12827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R68
SonicParanoid	1	1.000	-	-		X3674
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.690