DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment styk1b and btl

DIOPT Version :9

Sequence 1:	NP_001292494.1	Gene:	styk1b / 324714	ZFINID:	ZDB-GENE-030131-3435	Length:	447	Species:	Danio rerio
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	110/474 - (23%)
Similarity:	180/474 - (37%)	Gaps:	131/474 - (27%)

- Green bases have known domain annotations that are detailed below.

Zfish    10 SECEAGDALCEIRVYEQEVIIVPVIFFMMFLITLLFIMLLRFCPEKVERLQPASSRVSRTRRNLQ 74
            |.|.:||            :.:|||                       |::...:.||.|  ...
  Fly   659 SGCSSGD------------LQMPVI-----------------------RIEKQRTTVSTT--GTG 686

Zfish    75 GIDAPLGLNALEGEPIALDTTTYMTFNPATPARLDHANNVAFTDGMFGATASAFAKPRELPRQRL 139
            |.|...|.|..|   ..||:      |...|.:.....:: ..:|.||....|.|:  .|||
  Fly   687 GTDPAQGFNEYE---FPLDS------NWEIPRQQLSLGSI-LGEGAFGRVVMAEAE--GLPR--- 736

Zfish   140 PENFNGVAPLPASYSLKSDSPISLYRARMENRNVVLRVLKDSASNQESQSFLGFAAFLSQLGPHP 204
                               ||      ::....|.::::|:..::.:..|.:.....:..:|.|.
  Fly   737 -------------------SP------QLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHI 776

Zfish   205 FLPELLGVISLRAPLITVIEEMENRDLLGFLWRCR----QDNVGPDGMC---------QMTEKKI 256
            .:..|||..|...||..::|...:.:|..||.:.|    |.....||..         .:.||::
  Fly   777 NIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKEL 841

Zfish   257 FNMASHVASALDFLHGKDLHHCNLKARNVLVSRICTAKL--WGL-----DDLYVRTSGSGNYSED 314
            ...|..:|..:::|..:...|.:|.|||||||.....|:  :||     |..|.|.:.:|...
  Fly   842 TKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLP-- 904

Zfish   315 PGRKKWQAPELLAKRPSTPKSDIWSFGLLLYEMVTLGEVPFAEI-PVKELLQHHQRVKPIRKPNN 378
               .||.|||.|.::....:||:||:|:||:|::|.|:.|:..| ..:||..:....:.:.||..
  Fly   905 ---IKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAK 966

Zfish   379 CSNSLYSIIKSCCHWKEQDRPSLAEVRRKL---------------------------QSG-EKSA 415
            ||.::|.:::.|.|::...||:.||:....                           .|| |...
  Fly   967 CSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLETPPSSGDEDDG 1031

Zfish   416 SDSSVLRVPEPINIQQYLK 434
            ||:...|...|:..|...|
  Fly  1032 SDTETFRETSPLRYQYTYK 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
styk1b	NP_001292494.1	PKc_like	164..409	CDD:304357	71/292 (24%)
styk1b	NP_001292494.1	Pkinase_Tyr	164..408	CDD:285015	71/264 (27%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352
		IGc2	408..469	CDD:197706
		IG_like	492..583	CDD:214653
		Ig	507..583	CDD:299845
		PKc_like	700..1000	CDD:304357	85/341 (25%)
		TyrKc	712..996	CDD:197581	81/319 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810