DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ahcy and ahcy

DIOPT Version :9

Sequence 1:	NP_001285268.1	Gene:	Ahcy / 32471	FlyBaseID:	FBgn0014455	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	NP_954688.1	Gene:	ahcy / 387530	ZFINID:	ZDB-GENE-031219-6	Length:	433	Species:	Danio rerio

Alignment Length:	430	Identity:	347/430 - (80%)
Similarity:	380/430 - (88%)	Gaps:	0/430 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KPSYKVADISLAEWGRKAIIIAENEMPGLMACRKKYGPSKPLKGARITGCLHMTVQTAVLIETLV 67
            |..:|||||||||||||||.||||||||||..|:.||.|||||||||.||||||:|||||||||.
Zfish     4 KLPFKVADISLAEWGRKAIEIAENEMPGLMKMRELYGQSKPLKGARIAGCLHMTLQTAVLIETLT 68

  Fly    68 ELGAQVQWSSCNIFSTQDNAAAAIAATGVPVYAWKGETDEEYMWCIEQTLVFPDGQPLNMILDDG 132
            .|||:|||||||||||||:||||||.||||||||||||||||:||||||:.|.||||||||||||
Zfish    69 ALGAEVQWSSCNIFSTQDHAAAAIAKTGVPVYAWKGETDEEYVWCIEQTIYFKDGQPLNMILDDG 133

  Fly   133 GDLTNLVHEKFPQYLKNIKGLSEETTTGVHNLYKMFKEGRLGVPAINVNDSVTKSKFDNLYGCRE 197
            ||||||||:|:|:.|..|||:||||||||||||||.|.|.|.|||||||||||||||||||||||
Zfish   134 GDLTNLVHQKYPKLLAGIKGISEETTTGVHNLYKMLKSGELKVPAINVNDSVTKSKFDNLYGCRE 198

  Fly   198 SLIDGIKRATDVMIAGKVCCVAGYGDVGKGCAQALKGFGGRVIVTEVDPINALQAAMEGYEVTTM 262
            ||||||||||||||||||..|||||||||||.|||:|||.||||||:||||||||||||||||||
Zfish   199 SLIDGIKRATDVMIAGKVAVVAGYGDVGKGCVQALRGFGARVIVTEIDPINALQAAMEGYEVTTM 263

  Fly   263 EEASKEASIFVTTTGCRDIITSVHLQQMPDDAIVCNIGHFDIEIDVDWLNANAKEKVNVKPQVDR 327
            :||.||.:||||||||.||:...|.:.|.||:|||||||||.|||:.|||.:|.:|:|:||||||
Zfish   264 DEACKEGNIFVTTTGCEDILLGRHFEHMKDDSIVCNIGHFDCEIDMKWLNEHAAKKINIKPQVDR 328

  Fly   328 YTMQSGKHIILLAEGRLVNLGCAHGHPSFVMSNSFTNQVLAQIELWTKSDKYAVGVHVLPKILDE 392
            |.|::|:|||:||||||||||||.||||||||||||||||||||||..:.||.:||:.|||.|||
Zfish   329 YRMKNGRHIIVLAEGRLVNLGCAMGHPSFVMSNSFTNQVLAQIELWKNNSKYPLGVYFLPKKLDE 393

  Fly   393 EVASLHLEKLGVKLTKLTEKQATYLGVSQTGPFKPDHYRY 432
            |||:.||:||||||||||||||.|||:...||||||||||
Zfish   394 EVAAAHLDKLGVKLTKLTEKQAKYLGLPSEGPFKPDHYRY 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ahcy	NP_001285268.1	PRK05476	1..426	CDD:235488	339/422 (80%)
Ahcy	NP_001285268.1	AdoHcyase	6..431	CDD:283003	343/424 (81%)
ahcy	NP_954688.1	PRK05476	1..427	CDD:235488	339/422 (80%)
ahcy	NP_954688.1	AdoHcyase	6..432	CDD:283003	343/425 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581633
Domainoid	1	1.000	269	1.000	Domainoid score	I1811
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H554
Inparanoid	1	1.050	716	1.000	Inparanoid score	I625
OMA	1	1.010	-	-		QHG60675
OrthoDB	1	1.010	-	-		D371584at33208
OrthoFinder	1	1.000	-	-		FOG0004180
OrthoInspector	1	1.000	-	-		oto41632
orthoMCL	1	0.900	-	-		OOG6_100715
Panther	1	1.100	-	-	LDO	PTHR23420
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1281
SonicParanoid	1	1.000	-	-		X2929
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800