DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ahcy and Ahcy

DIOPT Version :9

Sequence 1:	NP_001285268.1	Gene:	Ahcy / 32471	FlyBaseID:	FBgn0014455	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	NP_057870.3	Gene:	Ahcy / 269378	MGIID:	87968	Length:	432	Species:	Mus musculus

Alignment Length:	430	Identity:	346/430 - (80%)
Similarity:	373/430 - (86%)	Gaps:	1/430 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KPSYKVADISLAEWGRKAIIIAENEMPGLMACRKKYGPSKPLKGARITGCLHMTVQTAVLIETLV 67
            |..||||||.||.|||||:.||||||||||..|:.|..|||||||||.|||||||:|||||||||
Mouse     4 KLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLV 68

  Fly    68 ELGAQVQWSSCNIFSTQDNAAAAIAATGVPVYAWKGETDEEYMWCIEQTLVFPDGQPLNMILDDG 132
            .|||:|:|||||||||||:||||||..|:||:||||||||||:|||||||.|.|| |||||||||
Mouse    69 ALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDG-PLNMILDDG 132

  Fly   133 GDLTNLVHEKFPQYLKNIKGLSEETTTGVHNLYKMFKEGRLGVPAINVNDSVTKSKFDNLYGCRE 197
            ||||||:|.|:||.|..|:|:||||||||||||||...|.|.|||||||||||||||||||||||
Mouse   133 GDLTNLIHTKYPQLLSGIRGISEETTTGVHNLYKMMSNGILKVPAINVNDSVTKSKFDNLYGCRE 197

  Fly   198 SLIDGIKRATDVMIAGKVCCVAGYGDVGKGCAQALKGFGGRVIVTEVDPINALQAAMEGYEVTTM 262
            ||||||||||||||||||..|||||||||||||||:|||.|||:||:||||||||||||||||||
Mouse   198 SLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTM 262

  Fly   263 EEASKEASIFVTTTGCRDIITSVHLQQMPDDAIVCNIGHFDIEIDVDWLNANAKEKVNVKPQVDR 327
            :||.||.:||||||||.|||...|.:||.||||||||||||:||||.|||.||.||||:||||||
Mouse   263 DEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDR 327

  Fly   328 YTMQSGKHIILLAEGRLVNLGCAHGHPSFVMSNSFTNQVLAQIELWTKSDKYAVGVHVLPKILDE 392
            |.:::|:.|||||||||||||||.|||||||||||||||:|||||||..|||.||||.|||.|||
Mouse   328 YWLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDE 392

  Fly   393 EVASLHLEKLGVKLTKLTEKQATYLGVSQTGPFKPDHYRY 432
            .||..||.||.|||||||||||.|||:...||||||||||
Mouse   393 AVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ahcy	NP_001285268.1	PRK05476	1..426	CDD:235488	338/422 (80%)
Ahcy	NP_001285268.1	AdoHcyase	6..431	CDD:283003	342/424 (81%)
Ahcy	NP_057870.3	AdoHcyase	8..431	CDD:214963	340/422 (81%)
Ahcy	NP_057870.3	NAD binding. /evidence=ECO:0000250	183..350		138/166 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837869
Domainoid	1	1.000	276	1.000	Domainoid score	I1726
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H554
Inparanoid	1	1.050	702	1.000	Inparanoid score	I663
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60675
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004180
OrthoInspector	1	1.000	-	-		oto95268
orthoMCL	1	0.900	-	-		OOG6_100715
Panther	1	1.100	-	-	LDO	PTHR23420
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1281
SonicParanoid	1	1.000	-	-		X2929
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790