DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ahcy and ahcy-1

DIOPT Version :9

Sequence 1:	NP_001285268.1	Gene:	Ahcy / 32471	FlyBaseID:	FBgn0014455	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	NP_491955.1	Gene:	ahcy-1 / 172408	WormBaseID:	WBGene00019322	Length:	437	Species:	Caenorhabditis elegans

Alignment Length:	434	Identity:	340/434 - (78%)
Similarity:	383/434 - (88%)	Gaps:	3/434 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKPSYKVADISLAEWGRKAIIIAENEMPGLMACRKKYGPSKPLKGARITGCLHMTVQTAVLIETL 66
            |||:||||||.||::|||.||:||||||||||.|.|||||:|||||||.||||||:|||||||||
Worm     4 SKPAYKVADIKLADFGRKEIILAENEMPGLMAMRSKYGPSQPLKGARIAGCLHMTIQTAVLIETL 68

  Fly    67 VELGAQVQWSSCNIFSTQDNAAAAIAATGVPVYAWKGETDEEYMWCIEQTLVFPDGQPLNMILDD 131
            ..|||:|||||||||||||:||||||.||||||||||||||||.||||||:||.|||||||||||
Worm    69 TALGAEVQWSSCNIFSTQDHAAAAIAQTGVPVYAWKGETDEEYEWCIEQTIVFKDGQPLNMILDD 133

  Fly   132 GGDLTNLVHEKFPQYLKNIKGLSEETTTGVHNLYKMFKEGRLGVPAINVNDSVTKSKFDNLYGCR 196
            |||||||||.|:||||..|:|||||||||||||.||..:|.|.||||||||||||||||||||.|
Worm   134 GGDLTNLVHAKYPQYLAGIRGLSEETTTGVHNLAKMLAKGDLKVPAINVNDSVTKSKFDNLYGIR 198

  Fly   197 ESLIDGIKRATDVMIAGKVCCVAGYGDVGKGCAQALKGFGGRVIVTEVDPINALQAAMEGYEVTT 261
            |||.||||||||||:||||..||||||||||.|.:||.||.||||||:|||||||||||||||||
Worm   199 ESLPDGIKRATDVMLAGKVAVVAGYGDVGKGSAASLKAFGSRVIVTEIDPINALQAAMEGYEVTT 263

  Fly   262 MEEASKEASIFVTTTGCRDIITSVHLQQMPDDAIVCNIGHFDIEIDVDWLNANAKEKVNVKPQVD 326
            :|||:.:|:|.||||||:||:|..|.:.:|:||||||:||||.||||.|||.||.:|..:|||||
Worm   264 LEEAAPKANIIVTTTGCKDIVTGKHFELLPNDAIVCNVGHFDCEIDVKWLNTNATKKDTIKPQVD 328

  Fly   327 RYTMQSGKHIILLAEGRLVNLGCAHGHPSFVMSNSFTNQVLAQIELWTK---SDKYAVGVHVLPK 388
            |||:::|:|:||||||||||||||.||||||||||||||||||:|||||   ..:|.:|::||||
Worm   329 RYTLKNGRHVILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQVELWTKFGTPQEYKLGLYVLPK 393

  Fly   389 ILDEEVASLHLEKLGVKLTKLTEKQATYLGVSQTGPFKPDHYRY 432
            .||||||.|||.:||||||||:::||:||||...||:|||||||
Worm   394 TLDEEVAYLHLAQLGVKLTKLSDEQASYLGVPVAGPYKPDHYRY 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ahcy	NP_001285268.1	PRK05476	1..426	CDD:235488	333/426 (78%)
Ahcy	NP_001285268.1	AdoHcyase	6..431	CDD:283003	334/427 (78%)
ahcy-1	NP_491955.1	PRK05476	1..431	CDD:235488	333/426 (78%)
ahcy-1	NP_491955.1	AdoHcyase	8..436	CDD:283003	334/427 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159745
Domainoid	1	1.000	256	1.000	Domainoid score	I1098
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H554
Inparanoid	1	1.050	699	1.000	Inparanoid score	I348
Isobase	1	0.950	-	0	Normalized mean entropy	S93
OMA	1	1.010	-	-		QHG60675
OrthoDB	1	1.010	-	-		D371584at33208
OrthoFinder	1	1.000	-	-		FOG0004180
OrthoInspector	1	1.000	-	-		oto19027
orthoMCL	1	0.900	-	-		OOG6_100715
Panther	1	1.100	-	-	LDO	PTHR23420
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1281
SonicParanoid	1	1.000	-	-		X2929
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790