DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Scamp and Scamp2

DIOPT Version :9

Sequence 1:	NP_001259572.1	Gene:	Scamp / 32470	FlyBaseID:	FBgn0040285	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_001365857.1	Gene:	Scamp2 / 24044	MGIID:	1346518	Length:	372	Species:	Mus musculus

Alignment Length:	374	Identity:	133/374 - (35%)
Similarity:	201/374 - (53%)	Gaps:	51/374 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGLDENPFGEPNLDNPFADPAIQQARRL-QSGAALVSLEDYNPFEE----QAKPQLQINSTNTAA 63
            |..|.|||.:|...|||.||::.|.... |||     |.::|||.|    ...|..|....:..|
Mouse     2 SAFDTNPFADPVDVNPFQDPSVTQLTNAPQSG-----LAEFNPFSETNAATTVPATQAPGPSQPA 61

  Fly    64 VVQP------------------------LSQNIPPPQTSSLGASA---------PSTSIQITSEE 95
            |:||                        |:...|..:.:.||..:         ||.::...::.
Mouse    62 VLQPSVEPAQPTPQLPVRQASKFLPARFLAAGEPSERQTLLGGDSISRDSHKRKPSKAVAAAAQA 126

  Fly    96 -LQRRQEELDRKAAELDRREQQLQGNVPQL----NNWPPLPDNFCVKPCFYQDFEVEIPPEFQKL 155
             |.|:|||||||||||:|:|::||.....|    |||||||....|||||||||..|||.::|::
Mouse   127 GLLRQQEELDRKAAELERKERELQNTAANLHVRDNNWPPLPSWCPVKPCFYQDFSTEIPADYQRI 191

  Fly   156 VKRLYYIWIFYTMTLLANVIGGLI-LLFHAGEFETFFLAIFYTMLFSPASYVCWFRPAYKAFRND 219
            .|.|||:|:.:::||..|::..|. ....|.....|.|:|.:.::|:|.:::||:||.|||||:|
Mouse   192 CKMLYYLWMLHSVTLFLNLLACLAWFTSDAANGTAFGLSILWFLIFTPCAFLCWYRPIYKAFRSD 256

  Fly   220 SSFNFMVFFFIYFFQTLYSIVQAVGFNKMGYCGFITAIGQFDGQASGIIVGILLLNVAFCFTAVA 284
            :||:|.||||::|.|.....:|.:|...:|..|::.|:...  :...:.|.|:::.||..||..|
Mouse   257 NSFSFFVFFFVFFCQIGIYFIQLIGLPNLGTSGWLAALSTM--KNGPLAVTIIMMVVAGFFTLCA 319

  Fly   285 VANVLMITKIHSIYRSTGASMAKAQAEFTTEFLRNQHVQEAASSAVNTA 333
            ..::.::.::|:.||.||||..:||.||:.....::..:.|||||...|
Mouse   320 GLSLFLLQRVHAFYRRTGASFQQAQEEFSQGIFSSRTFRGAASSAARGA 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scamp	NP_001259572.1	SCAMP	125..301	CDD:282056	69/176 (39%)
Scamp2	NP_001365857.1	SCAMP	161..336	CDD:398011	69/176 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831057
Domainoid	1	1.000	185	1.000	Domainoid score	I3367
eggNOG	1	0.900	-	-		E1_KOG3088
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2894
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51893
OrthoDB	1	1.010	-	-		D544579at33208
OrthoFinder	1	1.000	-	-		FOG0000703
OrthoInspector	1	1.000	-	-		otm42354
orthoMCL	1	0.900	-	-		OOG6_101583
Panther	1	1.100	-	-	O	PTHR10687
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X309
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770