DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Scamp and SCAMP2

DIOPT Version :9

Sequence 1:	NP_001259572.1	Gene:	Scamp / 32470	FlyBaseID:	FBgn0040285	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_001307707.1	Gene:	SCAMP2 / 10066	HGNCID:	10564	Length:	372	Species:	Homo sapiens

Alignment Length:	375	Identity:	137/375 - (36%)
Similarity:	203/375 - (54%)	Gaps:	53/375 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGLDENPFGEPNLDNPFADPAIQQARRLQSGAALVSLEDYNPFEE----QAKPQLQINSTNTAAV 64
            |..|.|||.:|...|||.||::.|......|    .|.::|||.|    ...|..|:..::..||
Human     2 SAFDTNPFADPVDVNPFQDPSVTQLTNAPQG----GLAEFNPFSETNAATTVPVTQLPGSSQPAV 62

  Fly    65 VQP--------------LSQNIPPPQTSS----------LGASA----------PSTSIQITSEE 95
            :||              .:...||.|..:          ||..:          |...:......
Human    63 LQPSVEPTQPTPQLLLRQASKFPPAQFLAVSELSERQMLLGGESILRDSYMRKLPKAVVSAAQAG 127

  Fly    96 LQRRQEELDRKAAELDRREQQLQGNVPQL----NNWPPLPDNFCVKPCFYQDFEVEIPPEFQKLV 156
            |.|:|||||||||||:|:|::||..|..|    |||||||....|||||||||..|||.::|::.
Human   128 LLRQQEELDRKAAELERKERELQNTVANLHVRQNNWPPLPSWCPVKPCFYQDFSTEIPADYQRIC 192

  Fly   157 KRLYYIWIFYTMTLLANVIGGLILLFHAGEFE---TFFLAIFYTMLFSPASYVCWFRPAYKAFRN 218
            |.|||:|:.:::||..|::.  .|.:.:|...   .|.|:|.:.::|:|.:::||:||.|||||:
Human   193 KMLYYLWMLHSVTLFLNLLA--CLAWFSGNSSKGVDFGLSILWFLIFTPCAFLCWYRPIYKAFRS 255

  Fly   219 DSSFNFMVFFFIYFFQTLYSIVQAVGFNKMGYCGFITAIGQFDGQASGIIVGILLLNVAFCFTAV 283
            |:||:|.||||::|.|....|:|.||...:|..|:|.|:...|..:  :.:.::::.||..||..
Human   256 DNSFSFFVFFFVFFCQIGIYIIQLVGIPGLGDSGWIAALSTLDNHS--LAISVIMMVVAGFFTLC 318

  Fly   284 AVANVLMITKIHSIYRSTGASMAKAQAEFTTEFLRNQHVQEAASSAVNTA 333
            ||.:|.::.::||:||.||||..:||.||:.....::....|||||...|
Human   319 AVLSVFLLQRVHSLYRRTGASFQQAQEEFSQGIFSSRTFHRAASSAAQGA 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scamp	NP_001259572.1	SCAMP	125..301	CDD:282056	74/178 (42%)
SCAMP2	NP_001307707.1	SCAMP	160..336	CDD:367838	74/179 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141106
Domainoid	1	1.000	185	1.000	Domainoid score	I3381
eggNOG	1	0.900	-	-		E1_KOG3088
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2913
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51893
OrthoDB	1	1.010	-	-		D544579at33208
OrthoFinder	1	1.000	-	-		FOG0000703
OrthoInspector	1	1.000	-	-		otm40287
orthoMCL	1	0.900	-	-		OOG6_101583
Panther	1	1.100	-	-	O	PTHR10687
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X309
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770