Protein Alignment Cngl and KCNH7

DIOPT Version :10

• Sequence 1: NP_727848.3
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: XP_011510411.1
• Gene: KCNH7 / 90134
• HGNCID: 18863
• Length: 1204
• Species: Homo sapiens
• Alignment Length: 1047
• Identity: 217/1047 - (20%)
• Similarity: 394/1047 - (37%)
• Gaps: 240/1047 - (22%)

  Fly   116 RHHHKMVRDDDNNSAAHSSDSKSPSQRKSRIGD---------------GASDPDSDWTRSNQRWM 165
            |.:..|::.....|.:.|.:|....:|.|.:.|               .||:.:....:.::.||
Human   246 RLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDNGRNVKVSRSWM 310

  Fly   166 KLRTTVQISSAIQKKPPLKREDSFLKRFST-RQIPE-----TQETVEDTGSESASGD---VDKSV 221
            .......|.|::..    ...||.|.::|| .:||:     ::...|...|...|.|   :...|
Human   311 AGGPFNHIKSSLLG----STSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKV 371

  Fly   222 KRRRRYLQKRRSVV--------------NPDENFY-----------FYWLMMLTVCVLYNLWTLI 261
            |.|...:.::.:.|              .|..|.:           :.||::|.|     ::|.|
Human   372 KDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLV-----IYTAI 431

  Fly   262 V-------------RQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYLEQG-LMVYDDRK 312
            .             .|...|...|.....:: |.:.|::||:||::..||.|:.|. .:|.|..|
Human   432 FTPYSAAFLLNDREEQKRRECGYSCSPLNVV-DLIVDIMFIIDILINFRTTYVNQNEEVVSDPAK 495

  Fly   313 LACHYVHSRDFIFDMIALIPLDLLQLKMGTHPLLRFTRFFKVYRSVRFYYIVESRTVWPNLWRVV 377
            :|.||.... |:.||:|.||.|||....|:..........|..|.:|...:......:......|
Human   496 IAIHYFKGW-FLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAV 559

  Fly   378 --NLIHILLILAHWFGCFYFLLSEAE-GFQGD---WV--------YPYRPGDYA---TLTRKYLG 425
              .|:.|..::|||..|.::.:...| .:..|   |:        ..|...|.:   ::..||:.
Human   560 LMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVT 624

  Fly   426 SLYWSTLTLTTIG-DLPTPETNAEPNFSVDGPRSIPRRGIKSRLLQFGSSYGYIFTIVSYLIGVF 489
            :||::..:||::| ...:|.||:|.                            ||:|...|||..
Human   625 ALYFTFSSLTSVGFGNVSPNTNSEK----------------------------IFSICVMLIGSL 661

  Fly   490 IFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGD 554
            ::|:|.|.|..:|....:....:...:...|.::|.|::|..:::|:..::.::|:   ...|.|
Human   662 MYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWT---YTNGID 723

  Fly   555 INTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAR 619
            :|..|...|:.|:.::.||:|.::|:....|:......|..|.:|.|.....|||::...|:|..
Human   724 MNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLT 788

  Fly   620 EMFIIADGILEVLSETGKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLA 684
            .::.::.|.:|:|.: ..|:..:...|.|||:..|.... .|..||||::.|.:|..:.|||:|.
Human   789 ALYFLSRGSIEILKD-DIVVAILGKNDIFGEMVHLYAKP-GKSNADVRALTYCDLHKIQREDLLE 851

  Fly   685 AMKDYPD--------------------------AQEILQTLG-----RKRLMEVRCVNKKYAKAQ 718
            .:..||:                          :|.:..:.|     |:|.:......:| ..:.
Human   852 VLDMYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEK-ENST 915

  Fly   719 SDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVKG-FRNVLKKSRTSRKSDE 782
            :|.|.:|....|....:.|.:        .:.|.|...:..:..:.|. |..::..|....|: .
Human   916 NDPEDSADTIRHYQSSKRHFE--------EKKSRSSSFISSIDDEQKPLFSGIVDSSPGIGKA-S 971

  Fly   783 SLEMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAE---AKDELHDKTPSPIGAGL--------- 835
            .|:.:   .|.|...::.:.:.|....|..|..|.|   |..:..|.:||.:....
Human   972 GLDFE---ETVPTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISETESD 1033

  Fly   836 ----PLLQRLRLLKEKQESIQEEPEREFSEGFPLIQRLQQLKIKNEPQANAAEPGVVMV------ 890
                .:.|||.||:|:...::.:...:       ||.:.||..|   |.....|...||
Human  1034 LTYGEVEQRLDLLQEQLNRLESQMTTD-------IQTILQLLQK---QTTVVPPAYSMVTAGSEY 1088

  Fly   891 ---------NTPPNISSKIDSHFAASQAGASHPGPNGGAIGISAPGQSLTVAQIKPIMKVSFKQK 946
                     .:.|..|.|.|..|:.|                         :|....:.:. |.|
Human  1089 QRPIIQLMRTSQPEASIKTDRSFSPS-------------------------SQCPEFLDLE-KSK 1127

  Fly   947 IQQMQGGGGGA--SSSPGPSTGAIAKKEPPKSLAL-VAKHATSEDPVAAAGLGLGSGSSSGIATI 1008
            ::..:....|.  :::...:..::.|::...||.| :.:..|...|:....|...|.|:.||..:
Human  1128 LKSKESLSSGVHLNTASEDNLTSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTVGIVGL 1192

  Fly  1009 SKRVVKP 1015
            .:.|..|
Human  1193 HRHVSDP 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_727848.3	Ion_trans	240..509	CDD:459842	73/311 (23%)
		CAP_ED	584..696	CDD:237999	33/137 (24%)
		dermokine	<1688..>1775	CDD:455732
KCNH7	XP_011510411.1	PAS_9	38..134	CDD:463873
		Ion_trans	417..679	CDD:459842	72/296 (24%)
		CAP_ED	753..864	CDD:237999	32/112 (29%)