Protein Alignment Cngl and KCNH7

DIOPT Version :9

• Sequence 1: NP_001245691.1
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: XP_011510411.1
• Gene: KCNH7 / 90134
• HGNCID: 18863
• Length: 1204
• Species: Homo sapiens
• Alignment Length: 1097
• Identity: 236/1097 - (21%)
• Similarity: 409/1097 - (37%)
• Gaps: 256/1097 - (23%)

  Fly   116 RHHHKMVRDDDNNSAAHSSDSKSPSQRKSRIGD---------------GASDPDSDWTRSNQRWM 165
            |.:..|::.....|.:.|.:|....:|.|.:.|               .||:.:....:.::.||
Human   246 RLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDNGRNVKVSRSWM 310

  Fly   166 KLRTTVQISSAIQKKPPLKREDSFLKRFST-RQIPE-----TQETVEDTGSESASGD---VDKSV 221
            .......|.|::..    ...||.|.::|| .:||:     ::...|...|...|.|   :...|
Human   311 AGGPFNHIKSSLLG----STSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKV 371

  Fly   222 KRRRRYLQKRRSVV--------------NPDENFY-----------FYWLMMLTVCVLYNLWTLI 261
            |.|...:.::.:.|              .|..|.:           :.||::|.|     ::|.|
Human   372 KDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLV-----IYTAI 431

  Fly   262 V-------------RQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYLEQG-LMVYDDRK 312
            .             .|...|...|.....:: |.:.|::||:||::..||.|:.|. .:|.|..|
Human   432 FTPYSAAFLLNDREEQKRRECGYSCSPLNVV-DLIVDIMFIIDILINFRTTYVNQNEEVVSDPAK 495

  Fly   313 LACHYVHSRDFIFDMIALIPLDLLQLKMGTHPLLRFTRFFKVYRSVRFYYIVESRTVWPNLWRVV 377
            :|.||.... |:.||:|.||.|||....|:..........|..|.:|...:......:......|
Human   496 IAIHYFKGW-FLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAV 559

  Fly   378 --NLIHILLILAHWFGCFYFLLSEAE-GFQGD---WV--------YPYRPGDYA---TLTRKYLG 425
              .|:.|..::|||..|.::.:...| .:..|   |:        ..|...|.:   ::..||:.
Human   560 LMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVT 624

  Fly   426 SLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLD 489
            :||::..:||::| ...:|.||:|.||:|...|||..::|:|.|.|..:|....:....:...:.
Human   625 ALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQML 689

  Fly   490 GAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKV 554
            ..|.::|.|::|..:::|:..::.::|:   ...|.|:|..|...|:.|:.::.||:|.::|:..
Human   690 RVKEFIRFHQIPNPLRQRLEEYFQHAWT---YTNGIDMNMVLKGFPECLQADICLHLNQTLLQNC 751

  Fly   555 TIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDF 619
            ..|:......|..|.:|.|.....|||::...|:|...::.::.|.:|:|.: ..|:..:...|.
Human   752 KAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKD-DIVVAILGKNDI 815

  Fly   620 FGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNK 684
            |||:..|.... .|..||||::.|.:|..:.|||:|..:..||:..:...|
Human   816 FGEMVHLYAKP-GKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLT-------------- 865

  Fly   685 KYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVKGFRNVLKKSRTS 749
                                                    :.::...|:|:             |
Human   866 ----------------------------------------NLELTFNLRHE-------------S 877

  Fly   750 RKSDESLEMQPLHNTSPRGSKILLKRMSRVRSDEKD---ADSAEAKDELHDKTPSPIGAGLPLLQ 811
            .|:| .|..|.::::.....|:..:::|.....||:   .|..::.|.:.....|.
Human   878 AKAD-LLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDPEDSADTIRHYQSSK--------- 932

  Fly   812 RLRLLKEKQDREERAVKSTPPQKSPPHSHVTCTLSPQESIQEEPEREFSEGFPLIQRLQQLKIKN 876
              |..:||:.|....:.|...::.|..|.:..: ||  .|.:....:|.|..|...|:...|..:
Human   933 --RHFEEKKSRSSSFISSIDDEQKPLFSGIVDS-SP--GIGKASGLDFEETVPTSGRMHIDKRSH 992

  Fly   877 EPQANAAEPGVVMVNTPPNISSKIDSHFAASQAGASHPGPNG--------GAIGISAPGQSLTVA 933
                                |.|..:...:.:...:||.|..        .|.|||.....||..
Human   993 --------------------SCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISETESDLTYG 1037

  Fly   934 QIKPIMKVSFKQKIQQMQGGGGGASSSPGPSTGAIAKKEPPKSLALVAKHATSEDPVAAAGLGLG 998
            ::        :|::..:|.......|........|        |.|:.|..|...|
Human  1038 EV--------EQRLDLLQEQLNRLESQMTTDIQTI--------LQLLQKQTTVVPP--------- 1077

  Fly   999 SGSSSGIATISKRVVKP--QSHRMATPLQS-DTDTDGTPIKPW--------SKLKLATLMSSSYT 1052
               :..:.|......:|  |..|.:.|..| .||...:|....        ||||....:||. .
Human  1078 ---AYSMVTAGSEYQRPIIQLMRTSQPEASIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSG-V 1138

  Fly  1053 SLTNCSPDDLASPLK---NYSLSNIPQQMESHTRP-RHHSARSSSRSPRH--GHHHH 1103
            .|...|.|:|.|.||   :.||....:|.:::..| ||.|...||.|...  |.|.|
Human  1139 HLNTASEDNLTSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTVGIVGLHRH 1195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	67/252 (27%)
		Ion_trans_2	382..476	CDD:285168	32/109 (29%)
		Crp	550..>680	CDD:223736	34/129 (26%)
		CAP_ED	556..668	CDD:237999	32/111 (29%)
KCNH7	XP_011510411.1	PAS_9	29..134	CDD:290162
		PAS	41..130	CDD:238075
		Ion_trans	456..679	CDD:278921	63/224 (28%)
		Ion_trans_2	<622..676	CDD:285168	21/53 (40%)
		Crp	747..>884	CDD:223736	39/206 (19%)
		CAP_ED	753..864	CDD:237999	32/112 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840