DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cngl and Cnga4

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_445948.2	Gene:	Cnga4 / 85258	RGDID:	619844	Length:	575	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	186/521 - (35%)
Similarity:	306/521 - (58%)	Gaps:	35/521 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 RRRRYLQKRRSVVNPDENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVV 287
            :.|::|    .|::|..::|::||..:...::|||..::.|..||:||.|....|.:.|..:|::
  Rat    19 KARKWL----PVLDPSGDYYYWWLNTMVFPIMYNLIIVVCRACFPDLQHSYLVAWFVLDYTSDLL 79

  Fly   288 FILDIIVQLRTGYLEQGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGTH-PLLRFTRF 351
            ::|||.|:..||:||||::|.|...:|..||.:..|:.|:.:|:|.|...:::|.| |.||..||
  Rat    80 YLLDIGVRFHTGFLEQGILVVDKGMIASRYVRTWSFLLDLASLVPTDAAYVQLGPHIPTLRLNRF 144

  Fly   352 FKVYRSVRFYYIVESRTVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVY--PYRP 413
            .:|.|....:...|:||.:||.:|:..|:..:.::.||..|.||.||...||..| |||  |.:|
  Rat   145 LRVPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQP 209

  Fly   414 GDYATLTRKYLGSLYWSTLTLTTIGDLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRN 478
            | :..|.|:||.|.|:|||.|||:||.|.|:...||:|.:..:|:.|..||||:|.:.:||.|.|
  Rat   210 G-FERLRRQYLYSFYFSTLILTTVGDTPLPDREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMN 273

  Fly   479 ANRLEF--ERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGL---LPDKL 538
            .....|  :..|  .|.||:...|...::|||:.||.:      :|....:...:.:   ||::|
  Rat   274 TADAAFYPDHAL--VKKYMKLQHVNKRLERRVIDWYQH------LQINKKMTNEVAILQHLPERL 330

  Fly   539 KTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEV 603
            :.|:|:.|:||.|.:|.|||.|:...|.:||||::...::||:.:||||::.|||:||.:|.|.|
  Rat   331 RAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGREMYIIREGQLAV 395

  Fly   604 LSETGKV-LTTMKAGDFFGEIGILNLDGL---NKRTADVRSVGYSELFSLSREDVLAAMKDYPDA 664
            :::.|.. ...:.||.:||||.|:|:.|.   |:|||:::|:|||:||.||:||:...:.:||.|
  Rat   396 VADDGVTQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQA 460

  Fly   665 QEILQTLGRKRLMEVRCVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIV 729
            |.:::..||:.|::   :||....|::.:.|...|.      :|..:|...|.|..:...::.:.
  Rat   461 QAVMEEKGREILLK---MNKLDVNAEAAEIALQEAT------ESRLKGLDQQLDDLQTKFARLLA 516

  Fly   730 D 730
            :
  Rat   517 E 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	91/224 (41%)
		Ion_trans_2	382..476	CDD:285168	44/96 (46%)
		Crp	550..>680	CDD:223736	56/133 (42%)
		CAP_ED	556..668	CDD:237999	51/115 (44%)
Cnga4	NP_445948.2	Ion_trans	58..273	CDD:278921	89/215 (41%)
		P-loop_NTPase	116..>174	CDD:304359	20/57 (35%)
		IQ-type. /evidence=ECO:0000250	292..302		1/9 (11%)
		Crp	342..>519	CDD:223736	65/185 (35%)
		CAP_ED	348..464	CDD:237999	51/115 (44%)
		CLZ	464..535	CDD:293134	12/63 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..575
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338700
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750