DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and Hcn1

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_445827.2	Gene:	Hcn1 / 84390	RGDID:	620688	Length:	902	Species:	Rattus norvegicus

Alignment Length:	1034	Identity:	232/1034 - (22%)
Similarity:	417/1034 - (40%)	Gaps:	261/1034 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 DTDVISPTGTSISGGGGGGGAGGAGGSGGAGGHSDGGYHKRHHHKMVRDDDNNSAAHSSDSKSPS 140
            |.:.:.|:....:|........|....|||.|...|                ||.....|
  Rat    16 DGNSVYPSKAPATGPAAADKRLGTPPGGGAAGKEHG----------------NSVCFKVD----- 59

  Fly   141 QRKSRIGDGASDP-----DSDWTRSNQRWMKLRTTVQISSAIQKKPPLKREDSFLKRFSTRQIPE 200
                  |.|..:|     |::..|....:|:.:.|..:...:.|             ||.|..
  Rat    60 ------GGGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNK-------------FSLRMF-- 103

  Fly   201 TQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPDENFYFYWLMMLTVCVLYNLWTLIVRQS 265
                    ||:.|.....:.||....:      :::|..:|.|||.:::.:.::.||..:.|..:
  Rat   104 --------GSQKAVEKEQERVKTAGFW------IIHPYSDFRFYWDLIMLIMMVGNLVIIPVGIT 154

  Fly   266 FPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYL--EQGLMVYDDRKLACHYVHSRDFIFDMI 328
            |...|.:.|  |:|.:..:|.||:||:|:..|||.:  :...::.|.:.:..:|:.|. |:.|.|
  Rat   155 FFTEQTTTP--WIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSW-FVVDFI 216

  Fly   329 ALIPLD--LLQLKMGTHP----------LLRFTRFFKVYRSVRFYYIVESRTVWPNLW------- 374
            :.||:|  .|.::.|...          ::|||:...:.|.:|...::.....|..::
  Rat   217 SSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 281

  Fly   375 ----RVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYPYRPGDYATLT--------RKYLGS 426
                |:.|||.::|:|.||.||..||:...:.|..| ||         :|.        ::|..:
  Rat   282 SAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWV---------SLNEMVNDSWGKQYSYA 337

  Fly   427 LYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDG 490
            |:.:...:..|| ....|.:.::...|::|.::|...:|..||....:|.:.:::|.:::.....
  Rat   338 LFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQ 402

  Fly   491 AKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVT 555
            .:.||..||:|..|::::..:|::.: :|:|   .|....|..|.|.|:.|:   ||.:..|.|.
  Rat   403 VEQYMSFHKLPADMRQKIHDYYEHRY-QGKI---FDEENILSELNDPLREEI---VNFNCRKLVA 460

  Fly   556 ---IFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAG 617
               :|....|.|:..::.|::..:|.|||.|.|:|.|.::|:.|..|:..|::::.|.: .:..|
  Rat   461 TMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEM-KLTDG 524

  Fly   618 DFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCV 682
            .:||||.:|.   ..:|||.||:..|..|:|||.::....:::||..:...:|:...||..   :
  Rat   525 SYFGEICLLT---KGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDR---I 583

  Fly   683 NKKYA----KAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVKGFRNVL 743
            .||.:    |.|.|.....:                   ::.||...|:||   |||
  Rat   584 GKKNSILLQKFQKDLNTGVF-------------------NNQENEILKQIV---KHD-------- 618

  Fly   744 KKSRTSRKSDESL------EMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAE--AKDELHDKTP 800
                  |:..:::      :|..|:.||...:.     .||:|:......:|.  :...||..:|
  Rat   619 ------REMVQAIPPINYPQMTALNCTSSTTTP-----TSRMRTQSPPVYTATSLSHSNLHSPSP 672

  Fly   801 S----------------------PIGAGL---------PLLQRLRLLKEKQDR-EERAVKSTPPQ 833
            |                      ||.:.|         |...:|.|:::.|.: ::..|:.|.||
  Rat   673 STQTPQPSAILSPCSYTTAVCSPPIQSPLATRTFHYASPTASQLSLMQQPQPQLQQSQVQQTQPQ 737

  Fly   834 KSPPHSHVTCTLSPQESIQEEPEREFSEGFPLIQRLQQLKIKNEPQANAAEPGVVMVNTPPNISS 898
            ..|         .||:..|::.:::..:     |:.||.:.:.:||.    ||   .:||.|...
  Rat   738 PQP---------QPQQPQQQQQQQQQQQ-----QQQQQQQQQQQPQT----PG---SSTPKNEVH 781

  Fly   899 KIDS--H----------FAASQAGASH--------PGPNGGAIGISAPGQSLTV--AQIKPIMKV 941
            |...  |          .:|||....|        |.|..|....|.|....||  ..::...:.
  Rat   782 KSTQALHNTNLTREVRPLSASQPSLPHEVSTMISRPHPTVGESLASIPQPMATVHSTGLQAGSRS 846

  Fly   942 SFKQKI---QQMQGGG--GGASSSPGPSTGAIAKKEPPKSLALVAKHATSEDPVAAAGL 995
            :..|::   :||..|.  ......|.|...|..::|.|   :::.|...:|.|..|:.|
  Rat   847 TVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAVQRESP---SVLNKDPDAEKPRFASNL 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	61/255 (24%)
		Ion_trans_2	382..476	CDD:285168	25/103 (24%)
		Crp	550..>680	CDD:223736	40/132 (30%)
		CAP_ED	556..668	CDD:237999	35/111 (32%)
Hcn1	NP_445827.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		16/85 (19%)
		PLN03192	122..>609	CDD:215625	132/537 (25%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:O60741	347..351		2/3 (67%)
		CAP_ED	464..572	CDD:237999	35/111 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..681		11/51 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..732		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	858..902		11/46 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338740
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3503
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.890