DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and SPIK

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_180131.3	Gene:	SPIK / 817099	AraportID:	AT2G25600	Length:	888	Species:	Arabidopsis thaliana

Alignment Length:	974	Identity:	187/974 - (19%)
Similarity:	344/974 - (35%)	Gaps:	268/974 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 GTSISGGGGGGGAGGAGGSGGAGGHSDGGYHKRHHHKMVRDDDNNSAAHSSDSKSPSQRKSRIG- 147
            |....|.||||..||                      ..:|.:::.|.|.|...:.||.....|
plant    10 GVKDDGEGGGGRGGG----------------------RTKDAEDDVADHLSRDGTMSQYSLSKGL 52

  Fly   148 ---DGASDPDSDWTRSNQRWMKLRTTVQISSAIQKKPPLKREDSFLKRFSTRQIPETQETVEDTG 209
               .||::..|                              .|..|.||
plant    53 LPSLGANNRSS------------------------------RDVILPRF---------------- 71

  Fly   210 SESASGDVDKSVKRRRRYLQKRRSVVNPDENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQSVP 274
                                    :|:|.:..|..|...|...|||..|.......|  ||:..|
plant    72 ------------------------IVSPFDPRYRAWETFLVFLVLYTAWASPFEFGF--LQKPRP 110

  Fly   275 TFWLICDSMTDVVFILDIIVQLRTGYLEQ--GLMVYDDRKLACHYVHSRDFIFDMIALIPLD--- 334
            .. .|.|::.:..|.:||::.....:|::  .|:|.|.:::|..|. |...|||:::..|.:
plant   111 PL-SILDNIVNGFFAVDIVLTFFVAFLDKVTYLLVDDPKRIAWRYA-STWLIFDVVSTFPYEIFG 173

  Fly   335 -LLQLKMGTHPLLRFTRFFKVYRSVRFYYIVESRTVWPNLW-RVVNLIHILLILAHWFGCFYFLL 397
             ||...:..:.:....|.:::.|....:..:|....:...| |...|:.:.|.:.|...||.:.:
plant   174 SLLHESIQGYGIFSMLRLWRLRRVSNCFARLEKDRKYSYFWVRCSKLLLVTLFVIHCGACFLYSI 238

  Fly   398 SEAEGFQGDWVYPYRPGDYATLTR----------KYLGSLYWSTLTLTTIGDLPTPETNAEYIFT 452
            :..        ||.....:..||.          :|..::|||..|.:|.|.......|:..:..
plant   239 AAH--------YPDPSKTFMALTDENWKESPIAVRYNTAMYWSITTFSTTGYGDIHGVNSREMTF 295

  Fly   453 IVSYLI-GVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSW 516
            |:.|:: .:.:.|.|:|.:.|::.:......:|...:..|..:.:.:.:|..::.:::.   :..
plant   296 ILFYMVFNLGLSAYIIGNMTNLVVHVTGRTRKFRDTIQAASGFGQRNNLPVRLQDQMVA---HLC 357

  Fly   517 SRGRIQGGG-DINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPG 580
            .|.|....| .....:..||..:::.::.::...|:.|:.:|.....:.|..||.:|||..|.|.
plant   358 LRYRTDSEGLQQQEIIDSLPKAIRSSISHYLFYEVVDKIYLFHGISNDLLFQLVTEMKAEYFPPK 422

  Fly   581 DSICRKGEVAREMFIIADGILEVLSETG---KVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVG 642
            :.:..:.|...:.:|:..|.:::::...   :|::..:.|..|||:|:|   ....:...||:..
plant   423 EDVILQNEAPTDFYILVTGAVDIIARVNGVEQVVSEAQRGHVFGEVGVL---CYRPQLFTVRTKR 484

  Fly   643 YSELFSLSREDVLAAMK-DYPDAQEILQTL------GRKRLMEVRCVNKKYAKAQSDKE---AAA 697
            .|:|..|:|..:|..:: :..|...|:..|      ....:|:....:.::..||...:   :..
plant   485 LSQLLRLNRTVLLNLVQANVGDGAIIMNNLLQHLKDSEDPVMKGVLADTEHMLAQGKMDLPLSLC 549

  Fly   698 YAAAHPHHHQSHHQGQVHQSDSSENSASKK----------------IVDKLKH-------DVKG- 738
            :|||.......|   |:.:..||.|...|.                :|..|:|       |.:|
plant   550 FAAARGDDLLLH---QLLRRGSSPNEMDKDGRTALHIAASKGSHYCVVLLLEHGADPNIRDSEGN 611

  Fly   739 ---FRNVLKKSRTSRKSDESLEMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAEA-KDELH--- 796
               :..::.:.|...|.           .:..|:|:.|..:|.......:.:..:| ||.:.
plant   612 VPLWEAIIGRHREIAKL-----------LAENGAKLSLDSVSYFSGLAVEKNCLDALKDIIKYGG 665

  Fly   797 DKTPSPIGAGLPLLQRL-----------------------------RLLKEKQDREERAVKS--- 829
            |.| .|.|.|...|.|.                             |.|.:.|..||  :|:
plant   666 DVT-LPDGNGTTALHRAVSEGHLEIVKFLLDQGADLDWPDSYGWTPRGLADHQGNEE--IKTLFH 727

  Fly   830 --TPPQKSPPHSHVTCTLSPQESIQEEPEREFSEGFPLIQRLQQLKIKNEPQANAAE----PGVV 888
              .|.:|.|         .|...|.:.|    ..|.||      :|..:||..::.|    .|.|
plant   728 NHRPVEKKP---------KPIPGIPQSP----VTGKPL------MKYSSEPTMHSGELVLDGGQV 773

  Fly   889 MVNTPPNISSKIDSHFA-ASQAGASHPG---------PNGGA-------IGISAPGQSLTVAQI 935
            :|:....:::..:|.|. .|.|.::..|         |.||.       :.||:|....|..::
plant   774 VVSQKRKLNNFRNSLFGIISAANSADDGGEVPRSPAVPGGGGSMIYPERVTISSPENGETGGKV 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	50/238 (21%)
		Ion_trans_2	382..476	CDD:285168	22/104 (21%)
		Crp	550..>680	CDD:223736	32/139 (23%)
		CAP_ED	556..668	CDD:237999	27/115 (23%)
SPIK	NP_180131.3	PLN03192	38..888	CDD:215625	176/924 (19%)
		ANK repeat	548..574	CDD:293786	8/28 (29%)
		ANK repeat	576..607	CDD:293786	3/30 (10%)
		ANK repeat	609..671	CDD:293786	12/73 (16%)
		ANK repeat	673..704	CDD:293786	3/30 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2706
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.880