DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and cnga1b

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	XP_701036.4	Gene:	cnga1b / 572249	ZFINID:	ZDB-GENE-110408-39	Length:	639	Species:	Danio rerio

Alignment Length:	666	Identity:	225/666 - (33%)
Similarity:	366/666 - (54%)	Gaps:	69/666 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 HKRHHHKMVRDDDNNSAAHSSDSKSPSQRKSRIGDGASDPDSDWTRSNQRWMKLRTTVQISSAIQ 178
            :||.....:.::.|||..:..:.|...:::.:                                :
Zfish    29 NKRPDAGALFNNTNNSNNNEEEDKKKKKKEKK--------------------------------E 61

  Fly   179 KKPPLKREDSFLKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPDENFYF 243
            ||...::::...|:...::    ||..|....:....:.:|..::.::...|...||:|..|.|:
Zfish    62 KKEKKEKKEKKEKKEKKKE----QEEKEKEKEKEKEKEKEKEKEKEKKEPLKEIEVVDPAGNMYY 122

  Fly   244 YWLMMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYLEQGLMVY 308
            .||.::|..|:||...:|.|..|.|||......|...|.::|.|::||::.:.|||||||||:|.
Zfish   123 NWLFVITCPVMYNWIFIIARACFEELQGDYLILWFFLDYLSDAVYLLDMVFRTRTGYLEQGLLVK 187

  Fly   309 DDRKLACHYVHSRDFIFDMIALIPLDLLQLKMG-THPLLRFTRFFKVYRSVRFYYIVESRTVWPN 372
            |.:||...|..|..|..|:.:::|.|:..|..| .:|.:|..:..::.|...|:...|:||.:||
Zfish   188 DQKKLRDRYTDSLQFRLDLASMVPTDIFYLYFGMNYPEIRMNKLLRINRLFEFFQRTETRTNFPN 252

  Fly   373 LWRVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYPYRPGD--YATLTRKYLGSLYWSTLTL 434
            ::|:.||:..::|:.||..|.|:..|:|.||..| :||| .|.|  :..|.|||..|:|||||||
Zfish   253 VFRISNLVMYIVIIIHWNACMYYSFSKAIGFGSDAFVYP-DPSDPEFGRLVRKYAYSMYWSTLTL 316

  Fly   435 TTIGDLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHK 499
            ||||:.|.|..|:||.|.:..:|:||.|||||||.||::|||.||.|.:|:..:|..|.||...|
Zfish   317 TTIGETPPPVENSEYFFVVTDFLVGVLIFATIVGNVGSMITNANAARADFQARIDAIKQYMSFRK 381

  Fly   500 VPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEF 564
            |...:::||::|:||.|:..:   ..|....|..|||||:.|:|::|:|..||||.||.:|:...
Zfish   382 VTKDLEKRVIKWFDYLWTNKK---AVDEREVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGL 443

  Fly   565 LHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETG-KVLTTMKAGDFFGEIGILNL 628
            |.:||||::..:::|||.||:||::.|||:||.:|.|.|:::.| .....:..|.:||||.|||:
Zfish   444 LVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISILNI 508

  Fly   629 DGL---NKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNKKYAKAQ 690
            .|.   |:|||::||:|||:||.||::|::.|:.:||||:.:|:..||:.||:...::.:.||..
Zfish   509 KGSRAGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPDAKAMLEEKGRQILMKDNLLDLELAKQG 573

  Fly   691 SD----KEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVKGFRNVLKKSRTSRK 751
            .|    :|............|:.....:.:.::::....|::..            |:|..||
Zfish   574 PDPKDMEEKVQKIGGVLEDLQTRFARLLAEQEAAQGKLKKRVTK------------LEKKMTS-- 624

  Fly   752 SDESLEMQPLHNTSPR 767
              |:| |:|...|:.:
Zfish   625 --ETL-MEPPPETADK 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	99/224 (44%)
		Ion_trans_2	382..476	CDD:285168	50/96 (52%)
		Crp	550..>680	CDD:223736	61/133 (46%)
		CAP_ED	556..668	CDD:237999	52/115 (45%)
cnga1b	XP_701036.4	Ion_trans	151..363	CDD:278921	93/212 (44%)
		Crp	429..629	CDD:223736	73/216 (34%)
		CAP_ED	435..551	CDD:237999	52/115 (45%)
		CLZ	551..621	CDD:293134	12/81 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578356
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750