DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and kcnh4b

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	XP_017213998.1	Gene:	kcnh4b / 567442	ZFINID:	ZDB-GENE-121214-54	Length:	1193	Species:	Danio rerio

Alignment Length:	1262	Identity:	272/1262 - (21%)
Similarity:	469/1262 - (37%)	Gaps:	334/1262 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 HKRHHHKMVRDDDNNSAAHSSDSKSPSQRKSRIGDGASDPDSDWTRSNQRWMKLRTTVQISSAIQ 178
            |::.||....||..||........|.::|:...  ......|.:||.:      :..|::|..:.
Zfish   137 HEKSHHSSKTDDKANSRTTEKSHISKARRRGHA--MIYQLTSQFTRDS------KNDVKLSRDMF 193

  Fly   179 KKPPLKREDSFLKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPDENFYF 243
            :||.|               ||.:...           |.||     |::....||    ....:
Zfish   194 EKPSL---------------PEYKVAA-----------VQKS-----RFILLHYSV----SKALW 223

  Fly   244 YWLMML-----TVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYLEQ 303
            .|:::|     .|.|.||    :...::.:: ::.....::.|...:::||||||:..||.|:.|
Zfish   224 DWMILLATFYVAVTVPYN----VCFTAYSDV-ETAGRSTIVSDIAVEMLFILDIILNFRTTYVSQ 283

  Fly   304 -GLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQ------------LKMGTHPLLRFTRFF-KV 354
             |.:||:.|.:..||..:..|: |::|.:|.|||.            ||  |..|||..|.. |:
Zfish   284 SGQVVYEPRSICLHYATTWFFV-DLVAALPFDLLYAFNITVTSLVHLLK--TVRLLRLLRLLQKL 345

  Fly   355 YRSVRFYYIVESRTVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAE-------GFQGDWVY--- 409
            .|..::..:|           :..|:.:..:||||..|.::::...|       .:...|::
Zfish   346 DRYSQYSAMV-----------LTLLMSMFALLAHWMACIWYIIGRKEMETNASGAWDIGWLHELG 399

  Fly   410 -----PYRPGDYA--TLTRKYLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATI 466
                 ||....:.  ::...|:.|||::..:||::| ......|:||.||::.:.|||..:.|.:
Zfish   400 KRLDKPYMNSTFGGPSVRSAYIASLYFTLSSLTSVGFGNVCANTDAEKIFSVCTMLIGALMHAVV 464

  Fly   467 VGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTAL 531
            .|.|..:|....:.|..:...:...|.::|.|::|..:|:|:|.::..:||   :..|.|:|..|
Zfish   465 FGNVTAIIQRMYSRRSLYHTRMKDLKDFIRVHRLPQQLKQRMLEYFQTTWS---VNNGIDVNELL 526

  Fly   532 GLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFII 596
            ...||:|:.::|:|:|..:| ::.:|:......|..|.|.:|....|||:.:.|:|:..:..:.:
Zfish   527 HDFPDELRADIAMHLNKDIL-QLPVFEAASRGCLRSLSLHIKTSFCTPGEYLIRQGDALQANYFV 590

  Fly   597 ADGILEVLSETGKVLTTMKAGDFFGEIGILNLDGLN---KRTADVRSVGYSELFSLSREDVLAAM 658
            ..|.||||.: ..||..:..||..|.    :|.|.|   |..|||:::.|.:|..:..:.:...:
Zfish   591 CSGSLEVLKD-NMVLAILGRGDLIGS----DLPGQNHVIKTNADVKALTYCDLQYIGVKGLSDVL 650

  Fly   659 KDYPDAQEILQTLGRKRLMEVRCVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENS 723
            :.||:...|. |:...|       |..|...:..:....|                  .|.|.::
Zfish   651 ELYPEYANIF-TIDIHR-------NLTYNLREGSETEQNY------------------PDFSVST 689

  Fly   724 ASKK--IVDKLKHDVKGF---------RNVLKKS------RTSRKS---DESLEM-------QPL 761
            .:|:  :|:|.....|.|         ||:|..:      |||..:   :|.::.       .|:
Zfish   690 ENKRPSVVEKADDPDKYFHVSSASSTCRNLLLPNLGSPVRRTSLGNLLGEELMQFNALRHCRSPV 754

  Fly   762 HNTSPRGSKILLKRMSRVRSDEKDADSAEAKDELHDKTPSPIGAGLPLLQRLRLLKEKQDREERA 826
            ...||..|.   |..|:|:...:...|          ||.||.            |.:.|....|
Zfish   755 RGWSPNPSP---KPPSKVQKQTQQPSS----------TPKPIH------------KTQTDSGSMA 794

  Fly   827 VKST-----------PPQKSP-------PHSHV-------TCTLSPQESIQEEPEREFSEGFPLI 866
            .|..           ||..||       .:.||       |.|....|:.|.....:.| |...:
Zfish   795 RKPAKLLIPTLNCFGPPDLSPRVVDGIEDNGHVFQFNVEDTSTKGTTETSQSSKTLDGS-GQVNV 858

  Fly   867 QRLQQLK-IK------NEPQANAAEPGVVMVNTPPNISSKIDSHFAASQAGASHPGPNGGAIGIS 924
            ..||:.| ::      |:...|..|....:.....:|...:.:|.||....|.......|...:|
Zfish   859 SLLQETKEVRETIDQLNKKMGNLKEEVANLTKDLHHIMHLLQAHIAARHYAAPFSSCPYGVHMMS 923

  Fly   925 APGQSLTVAQI---------------KPIMKVSFKQKIQQMQGGGGGASSSPGPSTGAIAKKEPP 974
            :...|::...|               :.::: |......::.||.|.|..:  ...|...:.||
Zfish   924 SAAVSMSPTYILGSNIHMQHKDHVVSEGLLR-STSWNHSRVNGGSGFAQHT--EKQGHFHQHEP- 984

  Fly   975 KSLALVAKHAT--SEDPVAAAGLGLGSGSSSGIATISKRVVKPQSHRMATPLQSDTDTDGTPIKP 1037
                  .:|:|  :.||.:.....:.:.|||.|:          .|..:|...:...|.....:|
Zfish   985 ------IQHSTVPANDPCSHDWSSILTSSSSSIS----------HHHFSTGPGTQGPTPREAPQP 1033

  Fly  1038 WSKLKLATLMSSSYTSLTNCSPDDLASPLKNYSLSNI-PQQMESHTRPRHHSARSSSRSPRHGHH 1101
            ...|........::.|::...|     .|:|....|: ...:.....|..:|....|..|
Zfish  1034 EGLLLSVCPGDGAHASISQSQP-----VLQNLFSQNLCGSGLSCKVTPSSYSHLQISTEP----- 1088

  Fly  1102 HHHHHGHHQHGQLQGPS-STCTNGSTTSQVNQVTASAKRDCLRLQKPEQHLPDGELTELGGNGRR 1165
                          .|| ||.|.|                       |.|    ..:|:|....:
Zfish  1089 --------------APSYSTLTLG-----------------------EVH----RTSEVGLAHNQ 1112

  Fly  1166 KLYQSVFDLSPEYCGLPFVKRLKILNERQKLAELERALQTRSFSLDC----SKSGPDSKVPITES 1226
            .|..|:|   |:....|..|.|.|:.     ..|..:.:....|.:|    .:.|.||:.  :||
Zfish  1113 NLVSSIF---PQEHSPPSPKELGIIP-----CSLVESSEVEHTSQECLLSNQRLGQDSET--SES 1167

  Fly  1227 LYRCYSDTSGIYSQFLSTYESTTSSTS 1253
              |....:.|:.||      |.:|.|:
Zfish  1168 --RSSESSVGLCSQ------SESSETT 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	63/252 (25%)
		Ion_trans_2	382..476	CDD:285168	28/111 (25%)
		Crp	550..>680	CDD:223736	35/132 (27%)
		CAP_ED	556..668	CDD:237999	31/114 (27%)
kcnh4b	XP_017213998.1	PAS_9	29..135	CDD:290162
		PAS	42..133	CDD:238075
		Ion_trans	261..480	CDD:278921	63/232 (27%)
		Ion_trans_2	<420..474	CDD:285168	19/53 (36%)
		Crp	547..>668	CDD:223736	34/133 (26%)
		CAP_ED	550..660	CDD:237999	31/114 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578349
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840