Protein Alignment Cngl and hcn3

DIOPT Version :9

• Sequence 1: NP_001245691.1
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: XP_689197.1
• Gene: hcn3 / 560709
• ZFINID: ZDB-GENE-060503-193
• Length: 639
• Species: Danio rerio
• Alignment Length: 616
• Identity: 144/616 - (23%)
• Similarity: 268/616 - (43%)
• Gaps: 112/616 - (18%)

  Fly   127 NNSAAHSSDSKSPSQRKSRIGDGASDPDSDWTRSNQRWMKLRTTVQISSAIQKKPPLKREDSFLK 191
            |::...|....||:.:...:..|.     |.|.:        ||..:::|   .|||..
Zfish    51 NHNQERSDSGASPTSKSLEVTAGL-----DGTTA--------TTTTVTAA---TPPLPH------ 93

  Fly   192 RFSTRQIPETQETVEDTGSESASGD-VDKSVKRRRRYLQKRRS---------------------- 233
                :.:||:...  ...||:..|. ||:|.     :||::.|
Zfish    94 ----KAMPESSGA--PVASEAEDGPFVDQST-----FLQRQFSSMLQPGVNKFSLRMFGSAKGVA 147

  Fly   234 ------------VVNPDENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDV 286
                        :::|..:|.|||.:::...::.||..|....:|.|.|.::|  |:..:..:|.
Zfish   148 AEQDRVKSFGVWIIHPYSDFRFYWDLVMLCLMMGNLVILPWGITFFEDQNTLP--WITFNVASDT 210

  Fly   287 VFILDIIVQLRTGYLE--QGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGTHP----- 344
            :|:.|::...|||.:|  ...::.|.:.::..|:... |:.|.|:.||:|.:.|.:....
Zfish   211 LFLADLVFNFRTGIMEGDNSEIILDPQIISRRYLRGW-FLVDFISSIPVDYIFLIVDIESRLESA 274

  Fly   345 ----------LLRFTRFFKVYRSVRFYYIVESRTVWPNLW-----------RVVNLIHILLILAH 388
                      ::|||:...:.|.:|...::.....|..::           |:||||.::|:|.|
Zfish   275 EVYRTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCH 339

  Fly   389 WFGCFYFLLSEAEGFQGD-WVYPYRPGDYATLTRKYLGSLYWSTLTLTTIG-DLPTPETNAEYIF 451
            |.||..|::...:.|... ||......: :|...:|..:|:.:...:..|| ....||...:...
Zfish   340 WDGCMQFMVPMLQDFPSTCWVSKNNMVN-STWDVQYSYALFMAMSHMLCIGYGAQAPEGPTDVWL 403

  Fly   452 TIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSW 516
            |::|.:||...:|..:|...|::.:.:|:..:::......:.||..||:|..|::|:..:|::
Zfish   404 TMISMIIGATCYAMFLGNATNLVQSLDASHRQYQEKYKQVEQYMSFHKLPADMRQRIHDYYEH-- 466

  Fly   517 SRGRIQGG-GDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPG 580
               |.||. .|....|..|.|.||.|:..:....::..:.:|....|.|:..|:.|::..:|.||
Zfish   467 ---RFQGKMFDEENILEELSDPLKEEIVNYNCRGLVANMPLFANADPHFVTVLLSKLRFEVFQPG 528

  Fly   581 DSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSE 645
            |.|.|:|.:.|:|:.|..|.:.|::...|. ..:..|.:||||.:|.   ..:|||.||:..|..
Zfish   529 DVIIREGTLGRKMYFIQHGCVSVITSDNKE-KKLNDGCYFGEICLLT---RGRRTASVRADTYCR 589

  Fly   646 LFSLSREDVLAAMKDYPDAQEILQTLGRKRL 676
            |:|||.:.....:::.|..:...:.:...||
Zfish   590 LYSLSVDSFNEVLEENPLMRRAFENVAVNRL 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	58/250 (23%)
		Ion_trans_2	382..476	CDD:285168	24/95 (25%)
		Crp	550..>680	CDD:223736	37/127 (29%)
		CAP_ED	556..668	CDD:237999	35/111 (32%)
hcn3	XP_689197.1	Ion_trans_N	124..166	CDD:285597	2/41 (5%)
		Ion_trans	186..429	CDD:278921	57/246 (23%)
		Ion_trans_2	<377..427	CDD:285168	12/49 (24%)
		Crp	498..>622	CDD:223736	37/127 (29%)
		CAP_ED	504..612	CDD:237999	35/111 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840