Protein Alignment Cngl and hcn3

DIOPT Version :10

• Sequence 1: NP_727848.3
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: XP_689197.1
• Gene: hcn3 / 560709
• ZFINID: ZDB-GENE-060503-193
• Length: 639
• Species: Danio rerio
• Alignment Length: 644
• Identity: 146/644 - (22%)
• Similarity: 270/644 - (41%)
• Gaps: 140/644 - (21%)

  Fly   127 NNSAAHSSDSKSPSQRKSRIGDGASDPDSDWTRSNQRWMKLRTTVQISSAIQKKPPLKREDSFLK 191
            |::...|....||:.:...:..|.     |.|.:        ||..:::|   .|||..
Zfish    51 NHNQERSDSGASPTSKSLEVTAGL-----DGTTA--------TTTTVTAA---TPPLPH------ 93

  Fly   192 RFSTRQIPETQETVEDTGSESASGD-VDKSVKRRRRYLQKRRS---------------------- 233
                :.:||:...  ...||:..|. ||:|.     :||::.|
Zfish    94 ----KAMPESSGA--PVASEAEDGPFVDQST-----FLQRQFSSMLQPGVNKFSLRMFGSAKGVA 147

  Fly   234 ------------VVNPDENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDV 286
                        :::|..:|.|||.:::...::.||..|....:|.|.|.::|  |:..:..:|.
Zfish   148 AEQDRVKSFGVWIIHPYSDFRFYWDLVMLCLMMGNLVILPWGITFFEDQNTLP--WITFNVASDT 210

  Fly   287 VFILDIIVQLRTGYLE--QGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGTHP----- 344
            :|:.|::...|||.:|  ...::.|.:.::..|:... |:.|.|:.||:|.:.|.:....
Zfish   211 LFLADLVFNFRTGIMEGDNSEIILDPQIISRRYLRGW-FLVDFISSIPVDYIFLIVDIESRLESA 274

  Fly   345 ----------LLRFTRFFKVYRSVRFYYIVESRTVWPNLW-----------RVVNLIHILLILAH 388
                      ::|||:...:.|.:|...::.....|..::           |:||||.::|:|.|
Zfish   275 EVYRTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCH 339

  Fly   389 WFGCFYFLLSEAEGFQGD-WVYPYRPGDYATLTRKYLGSLYWSTLTLTTIG-DLPTPETNAEPNF 451
            |.||..|::...:.|... ||......: :|...:|..:|:.:...:..|| ....||
Zfish   340 WDGCMQFMVPMLQDFPSTCWVSKNNMVN-STWDVQYSYALFMAMSHMLCIGYGAQAPE------- 396

  Fly   452 SVDGPRSIPRRGIKSRLLQFGSSYGYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLL 516
               ||..:                  ..|::|.:||...:|..:|...|::.:.:|:..:::...
Zfish   397 ---GPTDV------------------WLTMISMIIGATCYAMFLGNATNLVQSLDASHRQYQEKY 440

  Fly   517 DGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGG-GDINTALGLLPDKLKTELALHVNLSVLK 580
            ...:.||..||:|..|::|:..:|::     |.||. .|....|..|.|.||.|:..:....::.
Zfish   441 KQVEQYMSFHKLPADMRQRIHDYYEH-----RFQGKMFDEENILEELSDPLKEEIVNYNCRGLVA 500

  Fly   581 KVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAG 645
            .:.:|....|.|:..|:.|::..:|.|||.|.|:|.:.|:|:.|..|.:.|::...|. ..:..|
Zfish   501 NMPLFANADPHFVTVLLSKLRFEVFQPGDVIIREGTLGRKMYFIQHGCVSVITSDNKE-KKLNDG 564

  Fly   646 DFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRL 704
            .:||||.:|.   ..:|||.||:..|..|:|||.:.....:::.|..:...:.:...||
Zfish   565 CYFGEICLLT---RGRRTASVRADTYCRLYSLSVDSFNEVLEENPLMRRAFENVAVNRL 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_727848.3	Ion_trans	240..509	CDD:459842	66/298 (22%)
		CAP_ED	584..696	CDD:237999	35/111 (32%)
		dermokine	<1688..>1775	CDD:455732
hcn3	XP_689197.1	Ion_trans_N	124..166	CDD:400630	2/41 (5%)
		PLN03192	159..>606	CDD:215625	119/487 (24%)
		CAP_ED	504..612	CDD:237999	35/111 (32%)