DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cngl and kcnh7

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	XP_021332696.1	Gene:	kcnh7 / 560289	ZFINID:	ZDB-GENE-120214-39	Length:	1177	Species:	Danio rerio

Alignment Length:	1011	Identity:	234/1011 - (23%)
Similarity:	390/1011 - (38%)	Gaps:	199/1011 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 SDTDVISPTGTSISGGGGGG-----GAGGAGGSGGAGGHSDGGYHKRHHHKMVRDDDNNSAAHSS 134
            |..::..|||.|.|...|..     |....|......|..|   |........|.|...|.|.:|
Zfish   209 SPRELHPPTGESCSPSYGNDTRALIGQSYLGSCSPISGPQD---HSSPRGPWERVDPQESLATAS 270

  Fly   135 DSKSPS-----QRKSRIGD---------------GASDPDSDWTRSNQRWMKLRTTVQISSAIQK 179
            ...|.:     :|.|...|               .||:.:....:.::.||......||.|::..
Zfish   271 RRASRASMCTFRRASSTQDLEGLSTHTQRTYRDRHASEDNGRSIKVSRSWMAGGPFNQIKSSLLG 335

  Fly   180 KPPLKREDSFLKRFST-RQIPETQETVEDTGSESASGDVDKSVK---------RRRRYLQKRRSV 234
                ...||.|.::|| .:||.......:|..:........|.|         |......|...|
Zfish   336 ----STSDSNLTKYSTINKIPLITLNFSETNHDKRPSSPHSSEKTIIAPKVKDRTHNVTDKVTQV 396

  Fly   235 VN-------------PDEN---------FYFYWLMMLTVCVLYNLWTLIVRQSF----PELQQSV 273
            ::             |..|         |...|..::.:.|:|.........:|    ||.::..
Zfish   397 LSLGADVLPEYKLQTPRINKLTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDPEEEKRR 461

  Fly   274 PTFWL-----ICDSMTDVVFILDIIVQLRTGYLEQG-LMVYDDRKLACHYVHSRDFIFDMIALIP 332
            ...:.     :.|.:.|::||:||::..||.|:... .:|....|:|.||.....|| ||:|.||
Zfish   462 ECGYSCSPLNVVDLIVDIMFIVDILINFRTTYINANEEVVSHPAKIAVHYFKGWFFI-DMVAAIP 525

  Fly   333 LDLLQLKMGTHPLLRFTRFFKVYRSVRFYYIVESRTVWPNLWRVV--NLIHILLILAHWFGCFYF 395
            .|||..:.|:..........|..|.:|...:......:......|  .|:.|..::|||..|.::
Zfish   526 FDLLIFEGGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWY 590

  Fly   396 LLSEAEGFQGD----WV--------YPYRPGDYA---TLTRKYLGSLYWSTLTLTTIG-DLPTPE 444
            .:...|....|    |:        ..|...|.|   ::..||:.:||::..:||::| ...:|.
Zfish   591 AIGNVERLYLDHTIGWLDNLGISIGKQYNISDDASGPSIRDKYVTALYFTFSSLTSVGFGNVSPN 655

  Fly   445 TNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVL 509
            ||:|.||:|...|||..::|:|.|.|..:|....:....:...:...|.::|.|::|..:::|:.
Zfish   656 TNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHLQMLRVKEFIRFHQIPNPLRQRLE 720

  Fly   510 RWYDYSWSRGRIQGGGDIN-TALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMK 573
            .::.::|:   ...|.|:| ..|...|:.|:.::.||:|.::|:....|:......|..|.::.|
Zfish   721 EYFQHAWT---YTNGIDMNMEVLKGFPECLQADICLHLNKTLLQSCKAFRGATKGCLRALAMRFK 782

  Fly   574 AYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFGE-IGILNLDGLNKRTAD 637
            .....|||::...|:|...::.:|.|.:|:|.: ..|:..:...|.||| |.:....|  |..||
Zfish   783 TTHAPPGDTLVHGGDVLTALYFLARGSIEILRD-DIVVAILGKNDIFGEMIHLYAKPG--KANAD 844

  Fly   638 VRSVGYSELFSLSREDVLAAMKDYPDAQE-ILQTLGRKRLMEVRCVNKKYAKAQSDKEAAAYAAA 701
            ||::.|.:|.:::|||:|..:..||:..: .|..|  :....:|..|.|...|   .:...|.|.
Zfish   845 VRALSYCDLHTINREDLLEVLDMYPEFSDYFLSNL--ELTFNLRDENSKDTTA---PQRTLYTAV 904

  Fly   702 HPHHHQSHHQGQVHQSDSS----ENSASKKIVDKLKHDVKGFRNVLKKSRTSRKSDESLEMQPLH 762
            .....:.....:..:|..|    ..|..:::.|:..|.:.|        :...:.||....:||.
Zfish   905 SDSDTEDPDVRKRRRSTDSPIRPSRSDRERVRDRELHTLPG--------KEEEEEDEEETSRPLG 961

  Fly   763 ---------NTSPRGSKILLKRMSRVRSDEKDA-----------DSAEAKD-ELHDKTPSPIGAG 806
                     ||.|...   .|........:||.           |||:::| |..|...|.|..|
Zfish   962 LGQSLPVNLNTMPDPH---TKDCVENNLFQKDVCVEEWPCGNADDSAKSQDREGGDDCESDITFG 1023

  Fly   807 LPLLQRLRLLKEKQDREE-------RAVKSTPPQKSP--PHSHVTCTLSP--QESIQ-------E 853
             .:.|||.||:|..:|.|       :||.....::|.  |.::.|..:||  |:.||       :
Zfish  1024 -EMEQRLDLLQENLNRLEAQMTSDIQAVLQLLQRQSALGPPAYSTVAVSPEYQKPIQPVTAIQTQ 1087

  Fly   854 EPERE----------------FSEGFPLIQRLQ---QLKIK---NEPQAN----AAEPGVVMVNT 892
            .|:.|                .:...||:...|   :|.:|   ||..|:    |.:..:...:.
Zfish  1088 SPDLENAKDSRPAVPIETTSDVTAATPLVTDTQWEAELGLKPAENEASASQQPRALQMSIRQASL 1152

  Fly   893 PPNISSKIDSHFAASQAGASHPGPNGGAIGISAPGQ 928
            |.  |:....|..|....:|.||         .|||
Zfish  1153 PD--SAPAAGHTPALHRPSSDPG---------LPGQ 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	66/248 (27%)
		Ion_trans_2	382..476	CDD:285168	33/109 (30%)
		Crp	550..>680	CDD:223736	36/131 (27%)
		CAP_ED	556..668	CDD:237999	33/113 (29%)
kcnh7	XP_021332696.1	PAS_9	29..129	CDD:315989
		Ion_trans	428..690	CDD:306908	69/262 (26%)
		CAP_ED	765..876	CDD:237999	33/113 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578317
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840