Protein Alignment Cngl and kcnh6a

DIOPT Version :10

• Sequence 1: NP_727848.3
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: NP_998002.1
• Gene: kcnh6a / 405763
• ZFINID: ZDB-GENE-040702-5
• Length: 1186
• Species: Danio rerio
• Alignment Length: 1036
• Identity: 218/1036 - (21%)
• Similarity: 383/1036 - (36%)
• Gaps: 250/1036 - (24%)

  Fly   131 AHSSDSKSPSQRKSRIG--DGASDPDSDWTRSN------QRWMKLRT-------TVQISSAIQKK 180
            :||.:|....:|.|.:.  ||..|..||...||      ...|:.||       |:...|. :.:
Zfish   245 SHSRESMHSLRRASSLHDIDGMRDQWSDLKPSNLNSTSDSDLMRHRTIGRIPQVTISFGSD-RLR 308

  Fly   181 PPLKREDSFL--KRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRSV-VNPDENFY 242
            ||...|...:  .:...|....:::..:.|...|...||....|.:...:.|...: .:|   |.
Zfish   309 PPSPTEIEIIAPSKIKDRSQNVSEKVTQVTQVLSLGADVLPEYKLQAPRIHKWTILHYSP---FK 370

  Fly   243 FYWLMMLTVCVLYN-LWT-----LIVRQSFPELQQSVPTFWLIC------DSMTDVVFILDIIVQ 295
            ..|..::.:.|||. ::|     .::.:...|.::   |....|      |.:.||:||:||::.
Zfish   371 AVWDWIILLLVLYTAVFTPYSAAFLLNEQEDERRR---TCGYTCNPLNVVDLVVDVMFIIDILIN 432

  Fly   296 LRTGYLEQG-LMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGTHP--------LLRFTRF 351
            .||.|:... .:|.:..::|.||.... |:.|::|.||.|||..:.|:..        ||:..|.
Zfish   433 FRTTYVNHNDEVVSNPARIAQHYFKGW-FLIDIVAAIPFDLLIFRSGSDEPQTTTLIGLLKTARL 496

  Fly   352 FKVYRSVRFY--YIVESRTVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAE--------GFQGD 406
            .::.|..|..  |......|      :..|:....::|||..|.::.:...|        |.:..
Zfish   497 LRLVRVARKLDRYSEYGAAV------LFLLMCTFALIAHWLACIWYAIGNMERTSSARIGGMKIG 555

  Fly   407 WV--------YPYRPGDY---ATLTRKYLGSLYWSTLTLTTIG-DLPTPETNAEPNFSVDGPRSI 459
            |:        ..|...:.   .::..||:.:||::..:||::| ...:|.||.|.
Zfish   556 WLDNLADQIGKQYNDSNSFSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNPEK---------- 610

  Fly   460 PRRGIKSRLLQFGSSYGYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMR 524
                              ||:|...|||..::|:|.|.|..:|....:....:...:...|.::|
Zfish   611 ------------------IFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIR 657

  Fly   525 HHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQ 589
            .|::|||:::|:..::.::|.   ...|.|:|..|...|:.|:.::.||:|.|:|:....|:...
Zfish   658 FHQIPGGLRQRLEEYFQHAWP---YTNGIDMNAVLKGFPECLQADICLHLNRSLLQSCKAFRGAS 719

  Fly   590 PEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFGE-IGI 653
            ...|..|.::.:.....|||::...|:|...::.|:.|.:|:|.: ..|:..:...|.||| |.:
Zfish   720 KGCLRALAMRFRTTHAPPGDTLVHSGDVLTALYFISRGSIEILRD-DVVVAILGKNDIFGEPISL 783

  Fly   654 LNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNKKYAKAQ 718
            ....|  |.:||||::.|.:|..:.|:|:|..:..|||..:...: ..:....:|.|::......
Zfish   784 YARPG--KSSADVRALTYCDLHKILRDDLLEVLDMYPDFSDNFWS-NLEITFNLRDVDRIMHPTP 845

  Fly   719 SDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVKGFRNVLKKSRTSRKSDES 783
            |:.....|  ..|.|.                                 ||.|:::|......:.
Zfish   846 SEDSDCGY--RRPRHR---------------------------------RNPLRRNRPDGMDRDG 875

  Fly   784 LEMQPLHNTSPRGS---KILLKRMSRVRSDEKDADSAEAKD----------------ELHDKTPS 829
            ::..|:...||.|:   .|.|.:...:.||...|..:..:|                |:.:.:||
Zfish   876 MDTYPVQPCSPVGNHRGAIPLSQWDELCSDGSPASLSSEEDMKPLVSGQGDMYSLGTEMQEFSPS 940

  Fly   830 PI------------------------GAGLPLLQRLRLLKEKQESIQEEPERE-------FSEGF 863
            .:                        .|.|.:......|.:::.|...|.:|.       :....
Zfish   941 AVSLMPSAHSTASAMAGPLTGAHQYTAAPLNISGVYSYLSDRRASEYSESQRRSSAVQACYHHHS 1005

  Fly   864 PLI-QRLQQLKIKNE---PQANAAEPGVV-------------MVNTPPNISSKIDSHFAASQAGA 911
            |.: .|..||:.:.|   .|.|..|..:.             |...||       ::.|.|....
Zfish  1006 PCVGDRPNQLQARLELLQSQLNRLETRMTADINVILQLLQRQMAPVPP-------AYSAVSPDPL 1063

  Fly   912 SHPGPNGGAIGI-----------------SAPGQSLTVAQIKPIMKVSFKQKIQQMQGGGGGASS 959
            :||.|......:                 |:||:|..|..:|.....|....|..........|.
Zfish  1064 AHPVPPAHPTSLYTTAAHNTTPSLQITDASSPGKSPDVDSLKEKSPDSLSSGIHLTVASTDTMSM 1128

  Fly   960 SPG-----PSTGAIAKKEPPKSLALVAKHATSEDPVAAAGLGLGSGSSSGIATISKRVVKP 1015
            ||.     ||.|.:.  :||..|....:..:..|.:.      |.|:..|...|.:.|..|
Zfish  1129 SPETELSVPSAGPLL--QPPGLLCSSLRFPSLPDSLE------GPGTLEGSPEIQRHVSDP 1181

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_727848.3	Ion_trans	240..509	CDD:459842	70/311 (23%)
		CAP_ED	584..696	CDD:237999	32/112 (29%)
		dermokine	<1688..>1775	CDD:455732
kcnh6a	NP_998002.1	PAS_9	38..130	CDD:463873
		Ion_trans	372..640	CDD:459842	69/305 (23%)
		CAP_ED	714..821	CDD:237999	32/109 (29%)