DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cngl and kcnh6a

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_998002.1	Gene:	kcnh6a / 405763	ZFINID:	ZDB-GENE-040702-5	Length:	1186	Species:	Danio rerio

Alignment Length:	1016	Identity:	224/1016 - (22%)
Similarity:	390/1016 - (38%)	Gaps:	210/1016 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 AHSSDSKSPSQRKSRIG--DGASDPDSDWTRSN------QRWMKLRT-------TVQISSAIQKK 180
            :||.:|....:|.|.:.  ||..|..||...||      ...|:.||       |:...|. :.:
Zfish   245 SHSRESMHSLRRASSLHDIDGMRDQWSDLKPSNLNSTSDSDLMRHRTIGRIPQVTISFGSD-RLR 308

  Fly   181 PPLKREDSFL--KRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRSV-VNPDENFY 242
            ||...|...:  .:...|....:::..:.|...|...||....|.:...:.|...: .:|   |.
Zfish   309 PPSPTEIEIIAPSKIKDRSQNVSEKVTQVTQVLSLGADVLPEYKLQAPRIHKWTILHYSP---FK 370

  Fly   243 FYWLMMLTVCVLYN-LWT-----LIVRQSFPELQQSVPTFWLIC------DSMTDVVFILDIIVQ 295
            ..|..::.:.|||. ::|     .::.:...|.::   |....|      |.:.||:||:||::.
Zfish   371 AVWDWIILLLVLYTAVFTPYSAAFLLNEQEDERRR---TCGYTCNPLNVVDLVVDVMFIIDILIN 432

  Fly   296 LRTGYLEQG-LMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGTHP--------LLRFTRF 351
            .||.|:... .:|.:..::|.||.... |:.|::|.||.|||..:.|:..        ||:..|.
Zfish   433 FRTTYVNHNDEVVSNPARIAQHYFKGW-FLIDIVAAIPFDLLIFRSGSDEPQTTTLIGLLKTARL 496

  Fly   352 FKVYRSVRFY--YIVESRTVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAE--------GFQGD 406
            .::.|..|..  |......|      :..|:....::|||..|.::.:...|        |.:..
Zfish   497 LRLVRVARKLDRYSEYGAAV------LFLLMCTFALIAHWLACIWYAIGNMERTSSARIGGMKIG 555

  Fly   407 WV--------YPYRPGDY---ATLTRKYLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIG 459
            |:        ..|...:.   .::..||:.:||::..:||::| ...:|.||.|.||:|...|||
Zfish   556 WLDNLADQIGKQYNDSNSFSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNPEKIFSICVMLIG 620

  Fly   460 VFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGG 524
            ..::|:|.|.|..:|....:....:...:...|.::|.|::|||:::|:..::.::|.   ...|
Zfish   621 SLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPGGLRQRLEEYFQHAWP---YTNG 682

  Fly   525 GDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEV 589
            .|:|..|...|:.|:.::.||:|.|:|:....|:......|..|.::.:.....|||::...|:|
Zfish   683 IDMNAVLKGFPECLQADICLHLNRSLLQSCKAFRGASKGCLRALAMRFRTTHAPPGDTLVHSGDV 747

  Fly   590 AREMFIIADGILEVLSETGKVLTTMKAGDFFGE-IGILNLDGLNKRTADVRSVGYSELFSLSRED 653
            ...::.|:.|.:|:|.: ..|:..:...|.||| |.:....|  |.:||||::.|.:|..:.|:|
Zfish   748 LTALYFISRGSIEILRD-DVVVAILGKNDIFGEPISLYARPG--KSSADVRALTYCDLHKILRDD 809

  Fly   654 VLAAMKDYPDAQEILQTLGRKRLMEVRCVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSD 718
            :|..:..|||..:...: ..:....:|.|::......|:.....|  ..|.|.
Zfish   810 LLEVLDMYPDFSDNFWS-NLEITFNLRDVDRIMHPTPSEDSDCGY--RRPRHR------------ 859

  Fly   719 SSENSASKKIVDKLKHDVKGFRNVLKKSRTSRKSDESLEMQPLHNTSPRGS---KILLKRMSRVR 780
                                 ||.|:::|......:.::..|:...||.|:   .|.|.:...:.
Zfish   860 ---------------------RNPLRRNRPDGMDRDGMDTYPVQPCSPVGNHRGAIPLSQWDELC 903

  Fly   781 SDEKDADSAEAKD----------------ELHDKTPSPIG------------AGLPLL------- 810
            ||...|..:..:|                |:.:.:||.:.            || ||.
Zfish   904 SDGSPASLSSEEDMKPLVSGQGDMYSLGTEMQEFSPSAVSLMPSAHSTASAMAG-PLTGAHQYTA 967

  Fly   811 --------------QRLRLLKEKQDREERAVKSTPPQKSPPHSHVTCTLSPQESIQEEPE----- 856
                          :|.....|.| |...||::.      .|.|..|.......:|...|
Zfish   968 APLNISGVYSYLSDRRASEYSESQ-RRSSAVQAC------YHHHSPCVGDRPNQLQARLELLQSQ 1025

  Fly   857 ------REFSEGFPLIQRLQQLKIKNEPQANAAEPGVVMVNTPPNISSKIDSHFAASQAGASH-P 914
                  |..::...::|.||:......|..:|..|..:....||       :|..:....|:| .
Zfish  1026 LNRLETRMTADINVILQLLQRQMAPVPPAYSAVSPDPLAHPVPP-------AHPTSLYTTAAHNT 1083

  Fly   915 GPNGGAIGISAPGQSLTVAQIKPIMKVSFKQKIQQMQGGGGGASSSPG-----PSTGAIAKKEPP 974
            .|:......|:||:|..|..:|.....|....|..........|.||.     ||.|.:.  :||
Zfish  1084 TPSLQITDASSPGKSPDVDSLKEKSPDSLSSGIHLTVASTDTMSMSPETELSVPSAGPLL--QPP 1146

  Fly   975 KSLALVAKHATSEDPVAAAGLGLGSGSSSGIATISKRVVKP 1015
            ..|....:..:..|.:.      |.|:..|...|.:.|..|
Zfish  1147 GLLCSSLRFPSLPDSLE------GPGTLEGSPEIQRHVSDP 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	64/257 (25%)
		Ion_trans_2	382..476	CDD:285168	30/113 (27%)
		Crp	550..>680	CDD:223736	33/130 (25%)
		CAP_ED	556..668	CDD:237999	32/112 (29%)
kcnh6a	NP_998002.1	PAS	29..132	CDD:238075
		PAS_9	29..130	CDD:290162
		Ion_trans_2	<583..637	CDD:285168	21/53 (40%)
		CAP_ED	714..821	CDD:237999	32/109 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578351
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840