DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and Kcnh4

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_001074663.1	Gene:	Kcnh4 / 380728	MGIID:	2156184	Length:	1018	Species:	Mus musculus

Alignment Length:	980	Identity:	206/980 - (21%)
Similarity:	360/980 - (36%)	Gaps:	262/980 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 PLKRE--DSFLKRFSTRQIPETQETVEDTGSESASGDVD--------------KSVKRRRRYLQK 230
            |:|.|  :..|..||.:.|  :|......||....||.:              :|.||:.|.:..
Mouse   115 PIKNEMGEVVLFLFSFKDI--SQSGGPGLGSPGIHGDNNHENSLGRRGTSSRLRSTKRQNRTVLH 177

  Fly   231 R---------RSVVNPDENFYFYWLMMLTVCVLYNLWTLIVRQSFPE-------------LQQSV 273
            |         :|.|..:.|.:                  ..:.|.||             |..|:
Mouse   178 RLTGHFGRRGQSSVKANSNLF------------------EPKPSVPEYKVASVGGSRCLLLHYSI 224

  Fly   274 P-----------TFW------------------------LICDSMTDVVFILDIIVQLRTGYLEQ 303
            |           ||:                        |:.|...:::||||||:..||.|:.|
Mouse   225 PKAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQ 289

  Fly   304 -GLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGTHPLLRFTRFFKVYRSVRFYYIVESR 367
             |.::...|.:..||:.:..|: |:||.:|.|||.:...|  :.......|..|.:|...:::..
Mouse   290 SGQVISAPRSIGLHYLATWFFV-DLIAALPFDLLYVFNIT--VTSLVHLLKTVRLLRLLRLLQKL 351

  Fly   368 TVWPNLWRVV--NLIHILLILAHWFGCFYFLLSEAEGFQGD-------WVY--------PYRPGD 415
            ..:.....||  .|:.:..:||||..|.::::...|....|       |::        ||..|.
Mouse   352 ERYSQCSAVVLTLLMSVFALLAHWMACVWYVIGRREMEANDPLLWDIGWLHELGKRLEEPYVNGS 416

  Fly   416 YATLTRK--YLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNR 477
            ....:|:  |:.:||::..:||::| ......|:||.||:|.:.|||..:.|.:.|.|..:|...
Mouse   417 AGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRM 481

  Fly   478 NANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTEL 542
            .:.|..:...:...|.::|.|::|..:|:|:|.::..:|:   :..|.|.|..|...||:|:.::
Mouse   482 YSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWA---VNSGIDANELLRDFPDELRADI 543

  Fly   543 ALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSET 607
            |:|:|..:| ::.:|.......|..|.|.:|.....||:.:.|:|:..:..:.:..|.||||.:
Mouse   544 AMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRD- 606

  Fly   608 GKVLTTMKAGDFFG----EIGILNLDGLN-----KRTADVRSVGYSELFSLSREDVLAAMKDYPD 663
            ..||..:..||..|    |:|.....|..     |.:|||:::.|..|..||...:...::.||:
Mouse   607 NMVLAILGKGDLIGADIPELGQEPGSGAGPSCVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPE 671

  Fly   664 -AQEILQTLGRKRLMEVR-----------CVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQ 716
             |......|.|.....:|           ..:.:.::|:||...::.....|...::       :
Mouse   672 YAAAFRAGLPRDLTFNLRQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLPSITET-------E 729

  Fly   717 SDSSENSASK-----------------KIVDKLKHDVKGFRNVLKKSRTSRKSDESLE---MQPL 761
            ..:...:.||                 .:|..|..::..|..::.....|.....:|.   ..|.
Mouse   730 GGTEPGAGSKPRRPHLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPTPSPALAGRGQSPS 794

  Fly   762 HNTSPRGS------KILLKRMSR----------VRSDEKDADSAEAKDELHDKTPSPIGAGLPLL 810
            .:..||||      ::|:..:..          |...|..:::|||......|.|.|
Mouse   795 PHGPPRGSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSSNTAEAPTFRFSKRPEP-------- 851

  Fly   811 QRLRLLKEKQDREERAVKSTPPQKSPPHSHVTCTLSPQE------SIQEEPEREFSEGFPLIQRL 869
                          ...:|..|...|..|....|.:.:|      .:.:|..|...|...|.:.|
Mouse   852 --------------TRTRSQAPPSGPRLSRELATEAAEEVKEKVCRLNQEISRLNQEVSQLSREL 902

  Fly   870 QQ----LKIKNEPQANAAEPGVV----------------MVNTPPNISSKIDSHFAASQAGASHP 914
            :|    |:.:..|.::.|.|..:                |...||.:.:        :.....|.
Mouse   903 RQVMGLLQARLGPPSHTAGPAWLPDLPCPHQRLPCISPHMSGPPPGLQN--------TTLAVVHC 959

  Fly   915 GPNGGAIGISAPGQSLTVAQIKPIMKVSFKQKIQQMQGGGGGASSSPGPSTGAIAKKEPPKSLAL 979
            ..:.|.:.|.|....|..:.|.|.                   .|.|.|...:.|.:.||.:.:|
Mouse   960 PASVGTVEIGATPSELRPSTIPPY-------------------PSEPDPLGPSPAPEAPPLTPSL 1005

  Fly   980 VAKHA 984
            : ||:
Mouse  1006 L-KHS 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	70/289 (24%)
		Ion_trans_2	382..476	CDD:285168	31/111 (28%)
		Crp	550..>680	CDD:223736	36/139 (26%)
		CAP_ED	556..668	CDD:237999	33/121 (27%)
Kcnh4	NP_001074663.1	PAS_9	29..135	CDD:290162	7/21 (33%)
		PAS	42..133	CDD:238075	6/17 (35%)
		Ion_trans	244..486	CDD:278921	62/244 (25%)
		Ion_trans_2	<426..480	CDD:285168	19/53 (36%)
		CAP_ED	556..676	CDD:237999	33/120 (28%)
		bZIP	<864..902	CDD:304365	7/37 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835155
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840