DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cngl and KCNH2

DIOPT Version :9

Sequence 1:NP_001245691.1 Gene:Cngl / 32468 FlyBaseID:FBgn0263257 Length:1970 Species:Drosophila melanogaster
Sequence 2:NP_000229.1 Gene:KCNH2 / 3757 HGNCID:6251 Length:1159 Species:Homo sapiens


Alignment Length:1034 Identity:226/1034 - (21%)
Similarity:382/1034 - (36%) Gaps:267/1034 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 SGGGGGGGAGGAGGSGGAGGHSDGGYHKRHHHKMVRDDDNNSAAHSSDSKS-------------- 138
            |||.||.||.||                     :|.|.|...||.||:|.:              
Human   182 SGGAGGAGAPGA---------------------VVVDVDLTPAAPSSESLALDEVTAMDNHVAGL 225

  Fly   139 --PSQRKSRIGDGAS----------------DPDSDW-------TRSNQRWMKLRTTVQISSA-- 176
              ..:|::.:|.|:.                :||:..       |||.:....:|   :.|||  
Human   226 GPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVR---RASSADD 287

  Fly   177 -------IQKKPPL----------------KREDSFLKRFST-RQIPETQETVEDTGSES--ASG 215
                   :...||.                ...||.|.|:.| .:||:......|...:.  ||.
Human   288 IEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASP 352

  Fly   216 DVDKSV------KRRRRYLQKRRSVVN------PD----------------ENFYFYWLMMLTVC 252
            ..|:.:      :|.....:|...|::      |:                ..|...|..::.:.
Human   353 TSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLL 417

  Fly   253 VLYNLWTLIVRQSF--PELQQSVPTF--------WLICDSMTDVVFILDIIVQLRTGYLEQG-LM 306
            |:|.........:|  .|.::..|..        ..:.|.:.|::||:||::..||.|:... .:
Human   418 VIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEV 482

  Fly   307 VYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGTHPLL------RFTRFFKVYRSVRFYYIVE 365
            |....::|.||.... |:.||:|.||.|||....|:..|:      |..|..:|.|.:..|....
Human   483 VSHPGRIAVHYFKGW-FLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYG 546

  Fly   366 SRTVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAEGFQGD----WVY--------PYRPGDYA- 417
            :..::       .|:....::|||..|.::.:...|....|    |::        ||...... 
Human   547 AAVLF-------LLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGG 604

  Fly   418 -TLTRKYLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNAN 480
             ::..||:.:||::..:||::| ...:|.||:|.||:|...|||..::|:|.|.|..:|....:.
Human   605 PSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSG 669

  Fly   481 RLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALH 545
            ...:...:...:.::|.|::|..:::|:..::.::||   ...|.|:|..|...|:.|:.::.||
Human   670 TARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWS---YTNGIDMNAVLKGFPECLQADICLH 731

  Fly   546 VNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKV 610
            :|.|:|:....|:......|..|.:|.|.....|||::...|::...::.|:.|.:|:| ....|
Human   732 LNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL-RGDVV 795

  Fly   611 LTTMKAGDFFGEIGILNLDGL-NKRTADVRSVGYSELFSLSREDVLAAMKDYPD-------AQEI 667
            :..:...|.|||  .|||... .|...|||::.|.:|..:.|:|:|..:..||:       :.||
Human   796 VAILGKNDIFGE--PLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEI 858

  Fly   668 LQTL---------------------GRKRLMEVRCVNKKYAKAQSDKEA--AAYAAAHPHHHQSH 709
            ...|                     .|||.:..|....|..:...:..|  ...|.|.| ..:..
Human   859 TFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGP-SSRGR 922

  Fly   710 HQGQVHQSDSSENSASKKIVDKLKHDVKGFRNVLKKSRTSRKSDESLEMQPLHNTSPR------G 768
            ..|...:|.||..|:.:...|:                ...:|...|.:.|.  :|||      |
Human   923 PGGPWGESPSSGPSSPESSEDE----------------GPGRSSSPLRLVPF--SSPRPPGEPPG 969

  Fly   769 SKILLKRMSRVRSDEKDADSAEAKDELHDKTPSPI-GAGLPLLQRLRLLKEKQDREERAVKSTP- 831
            .:.|::      ..||.:|           |.:|: ||...:........:.:.|:.:.:...| 
Human   970 GEPLME------DCEKSSD-----------TCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPA 1017

  Fly   832 --------PQKSP---PHSHVTCTLSPQESIQEEPEREFSEGFPLIQRLQQLKIKNEPQANAA-- 883
                    |..||   |...|...|...:......|...|.....:.:|.|.::...|.|.:|  
Human  1018 PTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVT 1082

  Fly   884 EPGVVMVNTPPNI------SSKIDSHFAASQ--------AGASHPGPNGGAIGISAPGQ 928
            .||....:|.|.:      :..:||....||        .||......|....:|.|||
Human  1083 TPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQ 1141

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CnglNP_001245691.1 Ion_trans 260..481 CDD:278921 64/252 (25%)
Ion_trans_2 382..476 CDD:285168 31/108 (29%)
Crp 550..>680 CDD:223736 39/158 (25%)
CAP_ED 556..668 CDD:237999 33/119 (28%)
KCNH2NP_000229.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..314 14/85 (16%)
Ion_trans 409..668 CDD:306908 67/266 (25%)
Selectivity filter. /evidence=ECO:0000250 624..629 1/4 (25%)
CAP_ED 742..853 CDD:237999 32/113 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 870..982 25/136 (18%)
SSTK-IP 1012..1113 CDD:318128 20/100 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1038 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1119..1159 7/23 (30%)
PAS_9 29..130 CDD:315989
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145047
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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