Protein Alignment Cngl and Elk

DIOPT Version :9

• Sequence 1: NP_001245691.1
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Alignment Length: 1521
• Identity: 302/1521 - (19%)
• Similarity: 524/1521 - (34%)
• Gaps: 450/1521 - (29%)

  Fly    22 GYHSQLNYGS------------------TGAAAASSSSSGATATGLY---TMEAHEHEAGKF--- 62
            |.||....|:                  ||.:.|.....|.:...||   |.|.|:.:..|.
  Fly    24 GTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCSCHFLYGPDTKEEHKQQIEKSLSN 88

  Fly    63 --------------------------VKDVARQV-----------H------DCNSDTDVISPTG 84
                                      :|:..|.|           |      :.|.:.|.:....
  Fly    89 KMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHKDITHTKMLEMNVNEECDSVFALT 153

  Fly    85 TSISG----GGGGGGAGGAGGSGGAGGHSDGGYHKRHHHKMVRDDDNNSAAHSSDSKSPS----- 140
            .::.|    .|...|..|.||..|.||.:             ..|.:..|...::...|:
  Fly   154 AALLGARFRAGSNAGMLGLGGLPGLGGPA-------------ASDGDTEAGEGNNLDVPAGCNMG 205

  Fly   141 QRKSRIGDGASDPDSDWTRSNQRWMKLRTTVQISSAIQK-----KPPLKREDSFLKRFSTR-QIP 199
            :|:||                      ....|:|...:.     |..||..::|:  .||. ..|
  Fly   206 RRRSR----------------------AVLYQLSGHYKPEKGGVKTKLKLGNNFM--HSTEAPFP 246

  Fly   200 ETQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPDEN-FYFYWLMMLTVCVLYNLWTLIVR 263
            |.:               .:|:|:.|        ::.|... |...|..::.|...|....:...
  Fly   247 EYK---------------TQSIKKSR--------LILPHYGVFKGIWDWVILVATFYVALMVPYN 288

  Fly   264 QSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYL-EQGLMVYDDRKLACHYVHSRDFIFDM 327
            .:|.:..:...    :.|.:.:.:||:||::..||.:: .:|.:|.:.:::|.:|:... |..|:
  Fly   289 AAFAKADRQTK----VSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGW-FALDL 348

  Fly   328 IALIPLDLL---QLKMG--TH-PLLRFTRFFKVYRSVRFYYIVESRTVWPNLWRVVNLIHILLIL 386
            :|.:|.|.|   .|..|  :| .|::.||..::.|.::........|.     .::.|:.....|
  Fly   349 LAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLARLLQKIDRYSQHTA-----MILTLLMFSFTL 408

  Fly   387 -AHWFGCFYFLLS--EAEGFQGD---WVY---PYRPGDYATLT--RKYLGSLYWSTLTLTTIG-D 439
             |||..|.:::::  |.|.|...   |:.   ..:....|.||  ..|..:||::..:||::| .
  Fly   409 AAHWLACIWYVIAVKEYEWFPESNIGWLQLLAERKNASVAILTTAETYSTALYFTFTSLTSVGFG 473

  Fly   440 LPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGM 504
            ..:..|.||.:|||:..|||..:.|.:.|.|..:|....:.|..:|......|.::..|.:|..:
  Fly   474 NVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKEL 538

  Fly   505 KRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLV 569
            |:|:..::..|||   :..|.||...|...|::|:.::::|::..:| ::.||:......|..|.
  Fly   539 KQRIEDYFQTSWS---LSHGIDIYETLREFPEELRGDVSMHLHREIL-QLPIFEAASQGCLKLLS 599

  Fly   570 LKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFG-EIGI-------- 625
            |.:|.....||:.:..||:....::.:.:|.:||:.: ..|:..:..||..| :|.:
  Fly   600 LHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKD-DMVVAILGKGDLVGSDINVHLVATSNG 663

  Fly   626 --------LNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRC- 681
                    ...|.:.:.::|::::.|.:|..:....::..::.||:.|   |........::.|
  Fly   664 QMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQ---QQFANDIQHDLTCN 725

  Fly   682 VNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVKGFRNVLKKS 746
            :.:.|....||        ..|    |.....:.:.|.:...|        :...||    .|::
  Fly   726 LREGYENQDSD--------IGP----SFPLPSISEDDENREEA--------EEGGKG----EKEN 766

  Fly   747 RTSRKSDESLEMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAEAKDELHDKTPSP-IGAGLPLL 810
            .....|..|    ||||.|                          ...|| .|.|| :|.|.|..
  Fly   767 GGGPPSGAS----PLHNIS--------------------------NSPLH-ATRSPLLGMGSPRN 800

  Fly   811 QRLRLLKEKQDREERAVKSTPPQKSPPHSHVTCTLSPQESIQEEP-EREFSEG--FPLIQRLQQL 872
            |||    .::.|....::.|  .|.....:..|:|......:.|| |.|.|.|  .|.::||
  Fly   801 QRL----HQRGRSLITLRET--NKRHRTLNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERL--- 856

  Fly   873 KIKNEPQANAAEPGVVMVNTP-PNISSKIDSHFAASQAGASHPGPNGGAIGISAPGQSLTVAQIK 936
                :.|.:.....|..::.. .|..|.:......|.|..||              .||.....:
  Fly   857 ----DSQVSTLHQDVAQLSAEVRNAISALQEMTFTSNAMTSH--------------SSLKFPPAR 903

  Fly   937 PIMKVSFKQKIQQMQGGGGGASSSPGPSTGAIAKKEPPKSLALVAKHATSEDPVAAAGLGLGSGS 1001
            .|..:|      .:.|...|.:...|...|.:|..|      |.|...:|..|....|..:...:
  Fly   904 SIPNIS------GVAGTRSGVAVEHGLMGGVLAAAE------LAAMQRSSSHPPEVWGRDVQLPT 956

  Fly  1002 SSGIATISKRVVKPQSHRMATPLQSDTDTDGTPIKPWSKLKLA---------------------- 1044
            |:..::.:...|:|:  :..|...|.||........:.:..||
  Fly   957 SNTASSKAPSPVEPK--KTMTSRSSQTDFYRIDFPTFERFVLANPRLVLGLLGIEPAIKNEMDLL 1019

  Fly  1045 ----TLMSSSYTSLTNC-SPDD--LASPLKNYSLSN-IPQQMESHTRPRHHSARSSSRSPRHGHH 1101
                ||..|...::..| ||.|  |||..:....|: :|.....:......::.....:.:|...
  Fly  1020 QQKQTLQISPLNTIDECVSPSDHNLASSKERLITSSAVPTPGRIYPPLDDENSNDFRWTMKHSAS 1084

  Fly  1102 HHHHHGHHQHGQLQGPSSTCTNGSTTSQVNQVTASAKRDCLRLQKPEQHLPDGELTELGGNGRRK 1166
            ||               |.|.  ||.:               |..||:..|...|.
  Fly  1085 HH---------------SCCK--STDA---------------LLSPEEQPPISILP--------- 1108

  Fly  1167 LYQSVFDLSPEYCGLPFVKRLKILNERQKLAELERALQTRSFSLDCSKSGPDSKVPITESLYRCY 1231
                 .|.:|    .|.|         |::...:|:|:.       |.||.:|.:..:.|
  Fly  1109 -----VDATP----APSV---------QEVRSSKRSLRK-------STSGSNSSLSSSSS----- 1143

  Fly  1232 SDTSGIYSQFLSTYESTTSSTSISTNTSASASASASASASASDSNSRQLQY-------------- 1282
            |..|.:.||......:|.:|...|.::.:.||.:.:..||....:||..:|
  Fly  1144 SSNSCLVSQSTGNLTTTNASVHCSNSSQSVASVATTRRASWKLQHSRSGEYRRLSEATAEYSPPA 1208

  Fly  1283 -VPLPLSPESNETMERRKLKSILKKLQMGGGQQEEA----GPGTGT-----GAGAVMGTGSKVNS 1337
             .|||::..|.                  ||.:||:    ||...:     |.....|.|..:|.
  Fly  1209 KTPLPVAGVSY------------------GGDEEESVELLGPRRNSRPILLGVSQNQGQGQAMNF 1255

  Fly  1338 SAS-------QKG-QGLPAEPTLEGP 1355
            ..|       :|| :|||:..:|..|
  Fly  1256 RFSAGDADKLEKGLRGLPSTRSLRDP 1281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	58/239 (24%)
		Ion_trans_2	382..476	CDD:285168	31/105 (30%)
		Crp	550..>680	CDD:223736	27/146 (18%)
		CAP_ED	556..668	CDD:237999	25/128 (20%)
Elk	NP_477009.1	PAS	36..132	CDD:238075	13/95 (14%)
		PAS_3	41..129	CDD:285623	13/87 (15%)
		Ion_trans	285..516	CDD:278921	58/240 (24%)
		Ion_trans_2	<455..510	CDD:285168	19/54 (35%)
		Crp	583..>650	CDD:223736	16/67 (24%)
		CAP_ED	586..715	CDD:237999	26/132 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445392
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840