DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cngl and HCN1

DIOPT Version :9

Sequence 1:NP_001245691.1 Gene:Cngl / 32468 FlyBaseID:FBgn0263257 Length:1970 Species:Drosophila melanogaster
Sequence 2:NP_066550.2 Gene:HCN1 / 348980 HGNCID:4845 Length:890 Species:Homo sapiens


Alignment Length:1083 Identity:247/1083 - (22%)
Similarity:424/1083 - (39%) Gaps:317/1083 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 SAYRAHASAHKKILSSGYHSQLNYGSTGAAAASSSSSGATATGLYTMEAHEHEAGKFVKDVARQV 70
            |.:.|.|||                 |||..|::.....|..|.....|.||             
Human    19 SVFPAKASA-----------------TGAGPAAAEKRLGTPPGGGGAGAKEH------------- 53

  Fly    71 HDCNSDTDVISPTGTSIS---GGGGGGGAGGAGGSGGAGGHSDGGYHKRHHHKMVRDDDNNSAAH 132
                         |.|:.   .||||||.||.||...|||..|....:|.:..|.|         
Human    54 -------------GNSVCFKVDGGGGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQR--------- 96

  Fly   133 SSDSKSPSQRKSRIGDGASDPDSDWTRSNQRWMKLRTTVQISSAIQKKPPLKREDSFLKRFSTRQ 197
                                                   |.:|.:|..         :.:||.|.
Human    97 ---------------------------------------QFTSMLQPG---------VNKFSLRM 113

  Fly   198 IPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPDENFYFYWLMMLTVCVLYNLWTLIV 262
            .          ||:.|.....:.||....:      :::|..:|.|||.:::.:.::.||..:.|
Human   114 F----------GSQKAVEKEQERVKTAGFW------IIHPYSDFRFYWDLIMLIMMVGNLVIIPV 162

  Fly   263 RQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYL--EQGLMVYDDRKLACHYVHSRDFIF 325
            ..:|...|.:.|  |:|.:..:|.||:||:|:..|||.:  :...::.|.:.:..:|:.|. |:.
Human   163 GITFFTEQTTTP--WIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSW-FVV 224

  Fly   326 DMIALIPLD--LLQLKMGTHP----------LLRFTRFFKVYRSVRFYYIVESRTVWPNLW---- 374
            |.|:.||:|  .|.::.|...          ::|||:...:.|.:|...::.....|..::    
Human   225 DFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY 289

  Fly   375 -------RVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYPYRPGDYATLT--------RKY 423
                   |:.|||.::|:|.||.||..||:...:.|..| ||         :|.        ::|
Human   290 DLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWV---------SLNEMVNDSWGKQY 345

  Fly   424 LGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERL 487
            ..:|:.:...:..|| ....|.:.::...|::|.::|...:|..||....:|.:.:::|.:::..
Human   346 SYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEK 410

  Fly   488 LDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLK 552
            ....:.||..||:|..|::::..:|::.: :|:|   .|....|..|.|.|:.|:   ||.:..|
Human   411 YKQVEQYMSFHKLPADMRQKIHDYYEHRY-QGKI---FDEENILNELNDPLREEI---VNFNCRK 468

  Fly   553 KVT---IFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTM 614
            .|.   :|....|.|:..::.|::..:|.|||.|.|:|.|.::|:.|..|:..|::::.|.: .:
Human   469 LVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEM-KL 532

  Fly   615 KAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEV 679
            ..|.:||||.:|.   ..:|||.||:..|..|:|||.::....:::||..:...:|:...||.. 
Human   533 TDGSYFGEICLLT---KGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDR- 593

  Fly   680 RCVNKKYA----KAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHD---VK 737
              :.||.:    |.|.|.....:                   ::.||...|:||   |||   |:
Human   594 --IGKKNSILLQKFQKDLNTGVF-------------------NNQENEILKQIV---KHDREMVQ 634

  Fly   738 GFRNVLKKSRTSRKSDESLEMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAEAKDELHDKTPSP 802
            ....:.....|:..|..|       .|:|         .||:|:......:|.:....:..:|||
Human   635 AIAPINYPQMTTLNSTSS-------TTTP---------TSRMRTQSPPVYTATSLSHSNLHSPSP 683

  Fly   803 IGAGLPLLQRLRLLKEKQDREERAVKS---------TPPQKSPPHSHVTCTLSPQES----IQEE 854
                           ..|..:..|:.|         :||.:||..:......||..|    :|::
Human   684 ---------------STQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYASPTASQLSLMQQQ 733

  Fly   855 PEREFSEGFPLIQRLQQLKIKNEPQANAAEPGVVMVNTPPNISSKIDSHFAASQA---------- 909
            |:::..:..|         .:.:||..:.:|     .||.:.:.|.:.| .::||          
Human   734 PQQQVQQSQP---------PQTQPQQPSPQP-----QTPGSSTPKNEVH-KSTQALHNTNLTREV 783

  Fly   910 ---GASHPG-PNGGAIGISAP----GQSLTVAQIKPIMKVSFKQKIQQMQGGG---GGASSSP-- 961
               .||.|. |:..:..||.|    |:||          .|..|.:..:.|.|   ||.|:.|  
Human   784 RPLSASQPSLPHEVSTLISRPHPTVGESL----------ASIPQPVTAVPGTGLQAGGRSTVPQR 838

  Fly   962 -----GPSTGAIAKKE-----PPKSLALVAKHATS---EDPVA 991
                 ..|:|||....     ||...|.:.:.::|   .||.|
Human   839 VTLFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDA 881

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CnglNP_001245691.1 Ion_trans 260..481 CDD:278921 61/255 (24%)
Ion_trans_2 382..476 CDD:285168 25/103 (24%)
Crp 550..>680 CDD:223736 40/132 (30%)
CAP_ED 556..668 CDD:237999 35/111 (32%)
HCN1NP_066550.2 Disordered. /evidence=ECO:0000305|PubMed:28086084 1..93 31/116 (27%)
Ion_trans_N 98..140 CDD:285597 11/66 (17%)
Ion_trans 160..405 CDD:278921 61/256 (24%)
Selectivity filter. /evidence=ECO:0000305|PubMed:28086084 358..362 2/3 (67%)
Crp 469..>604 CDD:223736 41/141 (29%)
CAP_ED 475..583 CDD:237999 35/111 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 644..692 13/78 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 725..796 17/85 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 845..890 11/37 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145035
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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