Protein Alignment Cngl and Kcnh3

DIOPT Version :9

• Sequence 1: NP_001245691.1
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: NP_058804.1
• Gene: Kcnh3 / 27150
• RGDID: 71070
• Length: 1087
• Species: Rattus norvegicus
• Alignment Length: 1075
• Identity: 223/1075 - (20%)
• Similarity: 390/1075 - (36%)
• Gaps: 282/1075 - (26%)

  Fly   119 HKMVRDDDNNSAAHSSDSKSPSQRK-SRIGDGASDPDSDWTRSNQRWMKLRTTV-QISSAIQKKP 181
            ||.:.:..|.....:...:...:|: .|.|       |....:|:|  :.|..: .:|..:||:|
  Rat   130 HKDISETKNRGGPDNWKERGGGRRRYGRAG-------SKGFNANRR--RSRAVLYHLSGHLQKQP 185

  Fly   182 PLKR--------EDSFLKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPD 238
            ..|.        |...|..:....|.::...:...|:..|:.|
  Rat   186 KGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWD---------------------- 228

  Fly   239 ENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYL-E 302
             .|.....:.:.|.|.|::.....|:  |...:..|:   :||...:|:|||||::..||.:: :
  Rat   229 -GFILLATLYVAVTVPYSVCVSTARE--PSAARGPPS---VCDLAVEVLFILDIVLNFRTTFVSK 287

  Fly   303 QGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLL-----QLKMGTHPLLRFTRFFKVYRSVRFYY 362
            .|.:|:..:.:..||| :..|:.|:||.:|.|||     .:.:|.| ||:..|..::.|
  Rat   288 SGQVVFAPKSICLHYV-TTWFLLDVIAALPFDLLHAFKVNVYVGAH-LLKTVRLLRLLR------ 344

  Fly   363 IVESRTVWPNLWR--------VVNLIHILLILAHWFGCFYFLL-------SEAEGFQGDWVY--- 409
                  :.|.|.|        :..|:.:..:||||..|.:|.:       ||:|..:..|:.
  Rat   345 ------LLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQQEIENSESELPEIGWLQELA 403

  Fly   410 -----PY----RPGDYA-----------------------------TLTRKYLGSLYWSTLTLTT 436
                 ||    |..|..                             :|...|:.|||::..:||:
  Rat   404 RRLETPYYLVSRSPDGGNSSGQSENCSSSGGGSEANGTGLELLGGPSLRSAYITSLYFALSSLTS 468

  Fly   437 IG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKV 500
            :| ...:..|:.|.||:|.:.|||..:.|.:.|.|..:|....|.|..:.......:.|:|.|::
  Rat   469 VGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRI 533

  Fly   501 PGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFL 565
            |..:|:|:|.::..:|:   :..|.|....|..|||:|:.::|:|::..|| ::.:|:......|
  Rat   534 PKPLKQRMLEYFQATWA---VNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCL 594

  Fly   566 HDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFGEIGILNLDG 630
            ..|.|.::....|||:.:..:|:..:.::.:..|.:||| :.|.||..:..||..| ..:...:.
  Rat   595 RALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVL-KGGTVLAILGKGDLIG-CELPQREQ 657

  Fly   631 LNKRTADVRSVGYSELFSLSREDVLAAMKDYPD---------AQEILQTLGRKRLMEVRCVNKKY 686
            :.|..|||:.:.|..|..|....:..::..||:         ..|:...||
  Rat   658 VVKANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGELSYNLG-------------- 708

  Fly   687 AKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSD-SSENSASKKIVDKLKHDVKGFRNVLKKSRTSR 750
                    |...:|            :|..|. |.:|:....:.:|.....:|      .:.:..
  Rat   709 --------AGGVSA------------EVDTSSLSGDNTLMSTLEEKETDGEQG------HTISPA 747

  Fly   751 KSDE--SLEMQPLHNTSPRGSKILLKRMS--------RVRSDEKDADSAEAKDELHDKT------ 799
            .:||  |..:.|...:|...:|:|..|.:        |.|.........||....|.:|
  Rat   748 PADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPSRAGVLKPEAGPSAHPRTLDGLQL 812

  Fly   800 -PSP--------------IGAGLPLLQRLRLLKEKQDREERAVKSTPPQKS--------PPHSHV 841
             |.|              |..|....|.....:..|...|.:...:|..:|        |..:..
  Rat   813 PPMPWNVPPDLSPRVVDGIEDGCGSDQHKFSFRVGQSGPECSSSPSPGTESGLLTVPLVPSEARN 877

  Fly   842 TCTLSP-QESIQEEPER--EFSEGFPLIQRLQQL-----------KIKNEPQANAAEPGVVMVNT 892
            |.||.. ::::.|..|:  :..||...:::..||           ::..|....|...|::.
  Rat   878 TDTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLILVPQGEGQCPRVSGEGPCPATASGLLQ--- 939

  Fly   893 PPNISSKIDSHFAASQAGA------SHPGPNGGAIGISAPGQSLTVAQIKPIMKVSFKQKIQQMQ 951
            |..:.:...|:.....||:      .||.| |....:.||                       ..
  Rat   940 PLRVDTGASSYCLQPPAGSVLSGTWPHPRP-GHPPPLMAP-----------------------WP 980

  Fly   952 GGGGGASSSPGPSTGAI----AKKEPPKSLALVAKHATSEDPVAAAGLGLGSGSSSGIATISKRV 1012
            .|...:.|||.|...|:    :..|||.|..|.::.:|...|....     .|:.:|...
  Rat   981 WGPPASQSSPWPRATALWTSTSDSEPPGSGDLCSEPSTPASPPPPE-----EGARTGTPA----- 1035

  Fly  1013 VKPQSHRMATPLQSDTDTDGTPIKPWSKLKLATLM 1047
              |.|...||.........|....||....|..::
  Rat  1036 --PVSQAEATSTGEPPPGSGGRALPWDPHSLEMVL 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	71/283 (25%)
		Ion_trans_2	382..476	CDD:285168	34/142 (24%)
		Crp	550..>680	CDD:223736	32/138 (23%)
		CAP_ED	556..668	CDD:237999	28/120 (23%)
Kcnh3	NP_058804.1	PAS	42..133	CDD:238075	2/2 (100%)
		PAS_3	42..123	CDD:285623
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..161		4/30 (13%)
		Ion_trans	246..514	CDD:278921	71/286 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..436		1/19 (5%)
		Ion_trans_2	<455..509	CDD:285168	19/53 (36%)
		Selectivity filter. /evidence=ECO:0000250	468..473		1/4 (25%)
		CAP_ED	585..695	CDD:237999	27/111 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	733..813		16/85 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	975..1061		24/120 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338749
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840