Protein Alignment Cngl and Kcnh3

DIOPT Version :10

• Sequence 1: NP_727848.3
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: NP_058804.1
• Gene: Kcnh3 / 27150
• RGDID: 71070
• Length: 1087
• Species: Rattus norvegicus
• Alignment Length: 1118
• Identity: 225/1118 - (20%)
• Similarity: 392/1118 - (35%)
• Gaps: 368/1118 - (32%)

  Fly   119 HKMVRDDDNNSAAHSSDSKSPSQRK-SRIGDGASDPDSDWTRSNQRWMKLRTTV-QISSAIQKKP 181
            ||.:.:..|.....:...:...:|: .|.|       |....:|:|  :.|..: .:|..:||:|
  Rat   130 HKDISETKNRGGPDNWKERGGGRRRYGRAG-------SKGFNANRR--RSRAVLYHLSGHLQKQP 185

  Fly   182 PLKR--------EDSFLKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPD 238
            ..|.        |...|..:....|.::...:...|:..|:.|
  Rat   186 KGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWD---------------------- 228

  Fly   239 ENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYL-E 302
             .|.....:.:.|.|.|::.....|:  |...:..|:   :||...:|:|||||::..||.:: :
  Rat   229 -GFILLATLYVAVTVPYSVCVSTARE--PSAARGPPS---VCDLAVEVLFILDIVLNFRTTFVSK 287

  Fly   303 QGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLL-----QLKMGTHPLLRFTRFFKVYRSVRFYY 362
            .|.:|:..:.:..||| :..|:.|:||.:|.|||     .:.:|.| ||:..|..::.|
  Rat   288 SGQVVFAPKSICLHYV-TTWFLLDVIAALPFDLLHAFKVNVYVGAH-LLKTVRLLRLLR------ 344

  Fly   363 IVESRTVWPNLWR--------VVNLIHILLILAHWFGCFYFLL-------SEAEGFQGDWVY--- 409
                  :.|.|.|        :..|:.:..:||||..|.:|.:       ||:|..:..|:.
  Rat   345 ------LLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQQEIENSESELPEIGWLQELA 403

  Fly   410 -----PY----RPGDYA-----------------------------TLTRKYLGSLYWSTLTLTT 436
                 ||    |..|..                             :|...|:.|||::..:||:
  Rat   404 RRLETPYYLVSRSPDGGNSSGQSENCSSSGGGSEANGTGLELLGGPSLRSAYITSLYFALSSLTS 468

  Fly   437 IGDLPTPETNAEPNFSVDGPRSIPRRGIKSRLLQFGSSYGYIFTIVSYLIGVFIFATIVGQVGNV 501
            :|     ..|...|...:                      .||:|.:.|||..:.|.:.|.|..:
  Rat   469 VG-----FGNVSANTDTE----------------------KIFSICTMLIGALMHAVVFGNVTAI 506

  Fly   502 ITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKL 566
            |....|.|..:.......:.|:|.|::|..:|:|:|.::..:|:   :..|.|....|..|||:|
  Rat   507 IQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWA---VNNGIDTTELLQSLPDEL 568

  Fly   567 KTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEV 631
            :.::|:|::..|| ::.:|:......|..|.|.::....|||:.:..:|:..:.::.:..|.:||
  Rat   569 RADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEV 632

  Fly   632 LSETGKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEIL 696
            | :.|.||..:..||..| ..:...:.:.|..|||:.:.|.                      :|
  Rat   633 L-KGGTVLAILGKGDLIG-CELPQREQVVKANADVKGLTYC----------------------VL 673

  Fly   697 QTLGRKRLMEVRCVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLK 761
            |.|....|.|               ..|.|....|..                   |:.:..:|.
  Rat   674 QCLQLAGLHE---------------SLALYPEFAPRF-------------------SRGLRGELS 704

  Fly   762 HDVKGFRNVLKKSRTSRKSDESLEMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAEAKDELHDK 826
            ::: |...|..:..||..|.::..|..|                    :||:.|..:.    |..
  Rat   705 YNL-GAGGVSAEVDTSSLSGDNTLMSTL--------------------EEKETDGEQG----HTI 744

  Fly   827 TPSPIG-AGLPLL--------QRLRLLKEKQESIQEEPEREFSEGFPLIQRLQQLKIKNEPQANA 882
            :|:|.. ...|||        ...:||..::.:.:   .|....|.|  .|...||.:..|.|:.
  Rat   745 SPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPR---PRLGGRGRP--SRAGVLKPEAGPSAHP 804

  Fly   883 AEPGVVMV-----NTPPNISSKI----------DSH---FAASQAG-----ASHPGPNGGAIGIS 924
            .....:.:     |.||::|.::          |.|   |...|:|     :..||...|.:.:.
  Rat   805 RTLDGLQLPPMPWNVPPDLSPRVVDGIEDGCGSDQHKFSFRVGQSGPECSSSPSPGTESGLLTVP 869

  Fly   925 -APG------------QSLT-----VAQIKPIMKVSFKQKIQQM---QGGG-------------- 954
             .|.            |::|     |.|::..:: |.:|.:|.:   ||.|
  Rat   870 LVPSEARNTDTLDKLRQAVTELSEQVLQMREGLQ-SLRQAVQLILVPQGEGQCPRVSGEGPCPAT 933

  Fly   955 -----------GGASS---------------------------SPGPSTGAIAKKEP-PKSLALV 980
                       .||||                           :|.|.....::..| |::.||.
  Rat   934 ASGLLQPLRVDTGASSYCLQPPAGSVLSGTWPHPRPGHPPPLMAPWPWGPPASQSSPWPRATALW 998

  Fly   981 AKHATSEDPVAAAGLGLGSGS-SSGIATISKRVVKPQSHRMATPL---QSDTDTDGTP------- 1034
            ...:.||.|        |||. .|..:|.:......:..|..||.   |::..:.|.|
  Rat   999 TSTSDSEPP--------GSGDLCSEPSTPASPPPPEEGARTGTPAPVSQAEATSTGEPPPGSGGR 1055

  Fly  1035 IKPWSKLKLATLM 1047
            ..||....|..::
  Rat  1056 ALPWDPHSLEMVL 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_727848.3	Ion_trans	240..509	CDD:459842	75/330 (23%)
		CAP_ED	584..696	CDD:237999	23/111 (21%)
		dermokine	<1688..>1775	CDD:455732
Kcnh3	NP_058804.1	PAS_9	40..135	CDD:463873	2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..161		4/30 (13%)
		PLN03192	227..>654	CDD:215625	114/501 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..436		1/19 (5%)
		Selectivity filter. /evidence=ECO:0000250	468..473		1/9 (11%)
		cyc_nuc_ocin	<609..704	CDD:274839	26/152 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	733..813		19/88 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	975..1061		22/93 (24%)